Institution
University of Pittsburgh
Education•Pittsburgh, Pennsylvania, United States•
About: University of Pittsburgh is a education organization based out in Pittsburgh, Pennsylvania, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 87042 authors who have published 201012 publications receiving 9656783 citations. The organization is also known as: Pitt & Western University of Pennsylvania.
Topics: Population, Transplantation, Poison control, Cancer, Health care
Papers published on a yearly basis
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TL;DR: The most commonly used decellularization methods are described, and consideration give to the effects of these methods upon the biologic scaffold material.
2,007 citations
TL;DR: IFN alpha-2b is the first agent to show a significant benefit in relapse-free and overall survival of high-risk melanoma patients in a randomized controlled trial.
Abstract: PURPOSEInterferon alfa-2b (IFN alpha-2b) exhibits antitumor activity in metastatic melanoma and on this basis has been evaluated as an adjuvant therapy following surgery for deep primary (T4) or regionally metastatic (N1) melanoma.METHODSA randomized controlled study of IFN alpha-2b (Schering-Plough, Kenilworth, NJ) administered at maximum-tolerated doses of 20 MU/m2/d intravenously (i.v.) for 1 month and 10 MU/m2 three times per week subcutaneously (SC) for 48 weeks versus observation, was conducted by the Eastern Cooperative Oncology Group (ECOG) in 287 patients.RESULTSA significant prolongation of relapse-free survival (P = .0023, one-sided) and prolongation of overall survival (P = .0237, one-sided) was observed with IFN alpha-2b therapy in this trial, which is now mature with a median follow-up time of 6.9 years. The impact of treatment on relapse rate is most pronounced early during the treatment interval. The overall benefit of treatment in this trial was analyzed stratified by tumor burden and the...
2,002 citations
TL;DR: This article showed that self-explanation can also be facilitative when it is explicitly promoted, in the context of learning declarative knowledge from an expository text, and that prompted students who generated o large number of self-explaining (the high explainers) learned with greater understanding than low explainers.
1,995 citations
TL;DR: No single echocardiographic measure of dyssynchrony may be recommended to improve patient selection for CRT beyond current guidelines, given the modest sensitivity and specificity of these parameters in this multicenter setting.
Abstract: Background— Data from single-center studies suggest that echocardiographic parameters of mechanical dyssynchrony may improve patient selection for cardiac resynchronization therapy (CRT). In a prospective, multicenter setting, the Predictors of Response to CRT (PROSPECT) study tested the performance of these parameters to predict CRT response. Methods and Results— Fifty-three centers in Europe, Hong Kong, and the United States enrolled 498 patients with standard CRT indications (New York Heart Association class III or IV heart failure, left ventricular ejection fraction ≤35%, QRS ≥130 ms, stable medical regimen). Twelve echocardiographic parameters of dyssynchrony, based on both conventional and tissue Doppler–based methods, were evaluated after site training in acquisition methods and blinded core laboratory analysis. Indicators of positive CRT response were improved clinical composite score and ≥15% reduction in left ventricular end-systolic volume at 6 months. Clinical composite score was improved in 6...
1,990 citations
University of Texas Southwestern Medical Center1, University of Michigan2, University of Washington3, University of California, San Francisco4, University of California, Los Angeles5, University of Nebraska Omaha6, University of Pittsburgh7, Mayo Clinic8, Baylor University Medical Center9, Northwestern University10, Washington University in St. Louis11, Icahn School of Medicine at Mount Sinai12, Oregon Health & Science University13, University of Miami14, Yale University15, University of Alabama at Birmingham16, Harvard University17
TL;DR: The primary aim was to compare presenting clinical features and liver transplantation in patients with acute liver failure related to acetaminophen hepatotoxicity, other drugs, indeterminate factors, and other causes.
Abstract: Acetaminophen overdose and idiosyncratic drug reactions have replaced viral hepatitis as the most frequent causes of acute liver failure. The cause of liver failure and coma grade at admission were...
1,988 citations
Authors
Showing all 87737 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| JoAnn E. Manson | 270 | 1819 | 258509 |
| Graham A. Colditz | 261 | 1542 | 256034 |
| Yi Chen | 217 | 4342 | 293080 |
| David J. Hunter | 213 | 1836 | 207050 |
| David Miller | 203 | 2573 | 204840 |
| Rakesh K. Jain | 200 | 1467 | 177727 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Dennis W. Dickson | 191 | 1243 | 148488 |
| Terrie E. Moffitt | 182 | 594 | 150609 |
| Dennis S. Charney | 179 | 802 | 122408 |
| Ronald C. Petersen | 178 | 1091 | 153067 |
| David L. Kaplan | 177 | 1944 | 146082 |
| Jasvinder A. Singh | 176 | 2382 | 223370 |
| Richard K. Wilson | 173 | 463 | 260000 |
| Deborah J. Cook | 173 | 907 | 148928 |