Showing papers by "University of Portsmouth published in 2006"

Under-reporting of adverse drug reactions : a systematic review.

Abstract: The purpose of this review was to estimate the extent of under-reporting of adverse drug reactions (ADRs) to spontaneous reporting systems and to investigate whether there are differences between different types of ADRs. A systematic literature search was carried out to identify studies providing a numerical estimate of under-reporting. Studies were included regardless of the methodology used or the setting, e.g. hospital versus general practice. Estimates of under-reporting were either extracted directly from the published study or calculated from the study data. These were expressed as the percentage of ADRs detected from intensive data collection that were not reported to the relevant local, regional or national spontaneous reporting systems. The median under-reporting rate was calculated across all studies and within subcategories of studies using different methods or settings. In total, 37 studies using a wide variety of surveillance methods were identified from 12 countries. These generated 43 numerical estimates of under-reporting. The median under-reporting rate across the 37 studies was 94% (interquartile range 82-98%). There was no significant difference in the median under-reporting rates calculated for general practice and hospital-based studies. Five of the ten general practice studies provided evidence of a higher median under-reporting rate for all ADRs compared with more serious or severe ADRs (95% and 80%, respectively). In comparison, for five of the eight hospital-based studies the median under-reporting rate for more serious or severe ADRs remained high (95%). The median under-reporting rate was lower for 19 studies investigating specific serious/severe ADR-drug combinations but was still high at 85%. This systematic review provides evidence of significant and widespread under-reporting of ADRs to spontaneous reporting systems including serious or severe ADRs. Further work is required to assess the impact of under-reporting on public health decisions and the effects of initiatives to improve reporting such as internet reporting, pharmacist/nurse reporting and direct patient reporting as well as improved education and training of healthcare professionals.

Cosmological constraints from the SDSS luminous red galaxies

Abstract: We measure the large-scale real-space power spectrum P(k) using luminous red galaxies (LRGs) in the Sloan Digital Sky Survey (SDSS) and use this measurement to sharpen constraints on cosmological parameters from the Wilkinson Microwave Anisotropy Probe (WMAP). We employ a matrix-based power spectrum estimation method using Pseudo-Karhunen-Loeve eigenmodes, producing uncorrelated minimum-variance measurements in 20 k-bands of both the clustering power and its anisotropy due to redshift-space distortions, with narrow and well-behaved window functions in the range 0.01h/Mpc 0.1h/Mpc and associated nonlinear complications, yet agree well with more aggressive published analyses where nonlinear modeling is crucial.

The fourth data release of the Sloan Digital Sky Survey

Abstract: This paper describes the Fourth Data Release of the Sloan Digital Sky Survey (SDSS), including all survey-quality data taken through 2004 June. The data release includes five-band photometric data for 180 million objects selected over 6670 deg2 and 673,280 spectra of galaxies, quasars, and stars selected from 4783 deg2 of those imaging data using the standard SDSS target selection algorithms. These numbers represent a roughly 27% increment over those of the Third Data Release; all the data from previous data releases are included in the present release. The Fourth Data Release also includes an additional 131,840 spectra of objects selected using a variety of alternative algorithms, to address scientific issues ranging from the kinematics of stars in the Milky Way thick disk to populations of faint galaxies and quasars.

Incentive-based approaches to sustainable fisheries

Abstract: The failures of traditional target-species management have led many to propose an ecosystem approach to fisheries to promote sustainability. The ecosystem approach is necessary, especially to account for fishery-ecosystem interactions, but by itself is not sufficient to address two important factors contributing to unsustainable fisheries: inappropriate incentives bearing on fishers and the ineffective governance that frequently exists in commercial, devel- oped fisheries managed primarily by total-harvest limits and input controls. We contend that much greater emphasis must be placed on fisher motivation when managing fisheries. Using evidence from more than a dozen natural experi- ments in commercial fisheries, we argue that incentive-based approaches that better specify community and individual harvest or territorial rights and price ecosystem services and that are coupled with public research, monitoring, and ef- fective oversight promote sustainable fisheries. 710 Resume : Les echecs des amenagements traditionnels centres sur les especes-cibles ont incite plusieurs chercheurs a proposer des approches halieutiques basees sur les ecosystemes pour favoriser les peches durables. L'approche ecosys- temique est necessaire, en particulier, pour tenir compte des interactions peche-ecosysteme; elle ne suffit pas,

Origin of the Rheic Ocean: rifting along a Neoproterozoic suture?

Abstract: The Rheic Ocean is widely believed to have formed in the Late Cambrian–Early Ordovician as a result of the drift of peri-Gondwanan terranes, such as Avalonia and Carolina, from the northern margin of Gondwana, and to have been consumed in the Devonian Carboniferous by continent-continent collision during the formation of Pangea. Other peri-Gondwanan terranes (e.g., Armorica, Ossa-Morena, northwest Iberia, Saxo-Thuringia, Moldanubia) remained along the Gondwanan margin at the time of Rheic Ocean formation. Differences in the Neoproterozoic histories of these peri-Gondwanan terranes suggest the location of the Rheic Ocean rift may have been inherited from Neoproterozoic lithospheric structures formed by the accretion and dispersal of peri-Gondwanan terranes along the northern Gondwanan margin prior to Rheic Ocean opening. Avalonia and Carolina have Sm-Nd isotopic characteristics indicative of recycling of a juvenile ca. 1 Ga source, and they were accreted to the northern Gondwanan margin prior to voluminous late Neoproterozoic arc magmatism. In contrast, Sm-Nd isotopic characteristics of most other peri-Gondwanan terranes closely match those of Eburnian basement, suggesting they reflect recycling of ancient (2 Ga) West African crust. The basements of terranes initially rifted from Gondwana to form the Rheic Ocean were those that had previously accreted during Neoproterozoic orogenesis, suggesting the rift was located near the suture between the accreted terranes and cratonic northern Gondwana. Opening of the Rheic Ocean coincided with the onset of subduction beneath the Laurentian margin in its predecessor, the Iapetus Ocean, suggesting geodynamic linkages between the destruction of the Iapetus Ocean and the creation of the Rheic Ocean.

Primordial trispectrum from inflation

Abstract: We use the $\ensuremath{\delta}N$ formalism to describe the leading order contributions to the primordial power spectrum, bispectrum, and trispectrum in multiple-field models of inflation at leading order in a perturbative expansion. In slow-roll models where the initial field fluctuations at Hubble exit are nearly Gaussian, any detectable non-Gaussianity is expected to come from super-Hubble evolution. We show that the contribution to the primordial trispectrum can be described by two nonlinearity parameters, ${\ensuremath{\tau}}_{NL}$ and ${g}_{NL}$, which are dependent upon the second and third derivatives of the local expansion with respect to the field values during inflation.

Quality Assurance in UK Higher Education: Issues of Trust, Control, Professional Autonomy and Accountability.

Abstract: This article explores the issues of trust, control, professional autonomy and accountability in higher education quality assurance in the UK. The main part of this article is conceptual, but it includes results from semi-structured interviews with academic staff that were conducted at two “new university” business schools. Both institutions are broadly similar in their key characteristics and have experienced a transformation to university status in the early 1990s. The article argues that there has been a change from informal “light-touch” quality control systems based on local practices and a significant amount of trust and professional autonomy in the early 1990s to a highly prescribed process of audit-based quality control today. The article argues that accountability and transparency are important principles that academics should wholeheartedly embrace, but that the audit format adopted in the UK introduces a one-way accountability and provides “rituals of verification” (Power 1997) instead of fostering trust, has high opportunity costs and may well be detrimental to innovative teaching and learning.

On the Discursive Construction of ‘The Chinese Learner’

Abstract: Characterisations of ‘the Chinese learner’ in education and applied linguistics have frequently taken a ‘large culture’ approach, which involves describing the values, attitudes and learning practices of individuals in terms of fixed, homogeneous, reified national cultures. A shared Confucian cultural heritage is offered by way of explanation for supposedly consistent Chinese behaviours in Western classrooms. This paper examines some features of the deficit model of Chinese learner discourse attributed to Confucian cultural heritage (passive, lacking critical thinking, reliant on simplistic rote memorisation strategies resulting in surface learning, unwilling to participate in classroom talk), and refers to research findings which propose alternative characterisations and alternative explanations rooted in social and contextual factors. An alternative approach based on post-structuralist, critical pedagogy and cultural studies perspectives is considered which focuses on ‘small culture’ explanations for th...

Ending the war between Sales & Marketing.

Abstract: Sales departments tend to believe that marketers are out of touch with what's really going on in the marketplace. Marketing people, in turn, believe the sales force is myopic--too focused on individual customer experiences, insufficiently aware of the larger market, and blind to the future. In short, each group undervalues the other's contributions. Both stumble (and organizational performance suffers) when they are out of sync. Yet few firms seem to make serious overtures toward analyzing and enhancing the relationship between these two critical functions. Curious about the misalignment between Sales and Marketing, the authors interviewed pairs of chief marketing officers and sales vice presidents to capture their perspectives. They looked in depth at the relationship between Sales and Marketing in a variety of companies in different industries. Their goal was to identify best practices that could enhance the joint performance and increase the contributions of these two functions. Among their findings: The marketing function takes different forms in different companies at different product life cycle stages. Marketing's increasing influence in each phase of an organization's growth profoundly affects its relationship with Sales. The strains between Sales and Marketing fall into two main categories: economic (a single budget is typically divided, between Sales and Marketing, and not always evenly) and cultural (the two functions attract very different types of people who achieve success by spending their time in very different ways). In this article, the authors describe the four types of relationships Sales and Marketing typically exhibit. They provide a diagnostic to help readers assess their companies' level of integration, and they offer recommendations for more closely aligning the two functions.

First measurement of the clustering evolution of photometrically classified quasars

Abstract: We present new measurements of the quasar angular autocorrelation function from a sample of ~80,000 photometrically classified quasars taken from the First Data Release of the Sloan Digital Sky Survey. We find a best-fit model of ω(θ) = (0.066)θ-(0.98±0.15) for the angular correlation function, consistent with estimates of the slope from spectroscopic quasar surveys. We show that only models with little or no evolution in the clustering of quasars in comoving coordinates since a median redshift of z ~ 1.4 can recover a scale length consistent with local galaxies and active galactic nuclei (AGNs). A model with little evolution of quasar clustering in comoving coordinates is best explained in the current cosmological paradigm by rapid evolution in quasar bias. We show that quasar biasing must have changed from bQ ~ 3 at a (photometric) redshift of phot = 2.2 to bQ ~ 1.2-1.3 by phot = 0.75. Such a rapid increase with redshift in biasing implies that quasars at z ~ 2 cannot be the progenitors of modern L* objects; rather they must now reside in dense environments, such as clusters. Similarly, the duration of the UVX (ultraviolet-excess) quasar phase must be short enough to explain why local UVX quasars reside in essentially unbiased structures. Our estimates of bQ are in good agreement with recent spectroscopic results (Croom et al. 2005), which demonstrate that the implied evolution in bQ is consistent with quasars inhabiting halos of similar mass at every redshift. Treating quasar clustering as a bivariate function of both redshift and luminosity, we find no evidence for luminosity dependence in quasar clustering, and that redshift evolution thus affects quasar clustering more than changes in quasars' luminosity. Our results are robust against a range of systematic uncertainties. We provide a new method for quantifying stellar contamination in photometrically classified quasar catalogs via the correlation function.

Evolution and Environment of Early-Type Galaxies

Abstract: Chemical abundance indicators are studied using composite spectra, which we provide in tabular form. Tables of line strengths measured from these spectra and parameters derived from these line strengths are also provided. From these we find that at fixed luminosity, early-type galaxies in low-density environments are slightly bluer, with stronger O II emission and stronger Hδ and Hγ Balmer absorption lines, indicative of star formation in the not very distant past. These galaxies also tend to have systematically weaker D4000 indices. The Lick indices and α-element abundance indicators correlate weakly but significantly with environment. For example, at fixed velocity dispersion, Mg is weaker in early-type galaxies in low-density environments by 30% of the rms scatter across the full sample, whereas most Fe indicators show no significant environmental dependence. The galaxies in our sample span a redshift range that corresponds to look-back times of ~1 Gyr. We see clear evidence for evolution of line-index strengths over this time. Since the low-redshift population is almost certainly a passively aged version of the more distant population, age is likely the main driver for any observed evolution. We use the observed redshift evolution as a model-independent clock to identify indicators that are more sensitive to age than to other effects such as metallicity. In principle, for a passively evolving population, comparison of the trends with redshift and environment constrain how strongly the luminosity-weighted ages and metallicities depend on environment. We develop a method for doing this that does not depend on the details of stellar population synthesis models. Our analysis suggests that the galaxies that populate the densest regions in our sample are older by ~1 Gyr than objects of the same luminosity in the least dense regions, and that metallicity differences are negligible. We also use single-burst stellar population synthesis models, which allow for nonsolar α-element abundance ratios, to interpret our data. The combination of Hβ, Mg b, and Fe lines suggests that age, metallicity, and α-enhancement all increase with velocity dispersion. The objects at lower redshifts are older but have the same metallicities and α-enhancements as their counterparts of the same σ at higher redshifts, as expected if the low-redshift sample is a passively aged version of the sample at higher redshifts. In addition, objects in dense environments are less than 1 Gyr older and α-enhanced by ~0.02 relative to their counterparts of the same velocity dispersion in less dense regions, but the metallicities show no dependence on environment. This suggests that in dense regions, the stars in early-type galaxies formed at slightly earlier times and on a slightly shorter timescale than in less dense regions. Using HγF instead of Hβ leads to slightly younger ages but the same qualitative differences between environments. In particular, we find no evidence that objects in low-density regions are more metal-rich.

Career competencies for career success

Abstract: This article addresses the general question as to which competencies employees need to possess in order to engage in self-management in their career development. The authors distinguished and operationalized 6 career factors and competencies of self-management in career development. A quantitative study was performed using 1,579 employees in 16 Dutch companies to investigate the relationship between career competencies and career success. The results indicate that, among others, the factors career control and networking are strongly associated with career success. The results are discussed with respect to the facilitation organizations can provide for their employees' career actualization.

High redshift detection of the integrated Sachs-Wolfe effect

Abstract: We present evidence of a large angle correlation between the cosmic microwave background measured by WMAP and a catalog of photometrically detected quasars from the SDSS. The observed cross correlation is $0.30\ifmmode\pm\else\textpm\fi{}0.14\text{ }\text{ }\ensuremath{\mu}\mathrm{K}$ at zero lag, with a shape consistent with that expected for correlations arising from the integrated Sachs-Wolfe effect. The photometric redshifts of the quasars are centered at $z\ensuremath{\sim}1.5$, making this the deepest survey in which such a correlation has been observed. Assuming this correlation is due to the ISW effect, this constitutes the earliest evidence yet for dark energy and it can be used to constrain exotic dark energy models.

The 2df SDSS LRG and QSO survey: evolution of the luminosity function of luminous red galaxies to z= 0.6

Abstract: We present new measurements of the luminosity function (LF) of luminous red galaxies (LRGs) from the Sloan Digital Sky Survey (SDSS) and the 2dF SDSS LRG and Quasar (2SLAQ) survey. We have carefully quantified, and corrected for, uncertainties in the K and evolutionary corrections, differences in the colour selection methods, and the effects of photometric errors, thus ensuring we are studying the same galaxy population in both surveys. Using a limited subset of 6326 SDSS LRGs (with 0.17 < z < 0.24) and 1725 2SLAQ LRGs (with 0.5 < z < 0.6), for which the matching colour selection is most reliable, we find no evidence for any additional evolution in the LRG LF, over this redshift range, beyond that expected from a simple passive evolution model. This lack of additional evolution is quantified using the comoving luminosity density of SDSS and 2SLAQ LRGs, brighter than M0.2r − 5 log h0.7 = −22.5, which are 2.51 ± 0.03 × 10−7 L Mpc−3 and 2.44 ± 0.15 × 10−7 L Mpc−3, respectively (<10 per cent uncertainty). We compare our LFs to the COMBO-17 data and find excellent agreement over the same redshift range. Together, these surveys show no evidence for additional evolution (beyond passive) in the LF of LRGs brighter than M0.2r − 5 log h0.7 = −21 (or brighter than L*). We test our SDSS and 2SLAQ LFs against a simple ‘dry merger’ model for the evolution of massive red galaxies and find that at least half of the LRGs at z 0.2 must already have been well assembled (with more than half their stellar mass) by z 0.6. This limit is barely consistent with recent results from semi-analytical models of galaxy evolution.

A comparison of mainstream and special education for teenagers with Down syndrome: implications for parents and teachers.

Abstract: This article presents data from a research study designed to compare the achievements of teenagers with Down syndrome educated in mainstream classrooms or in special education classrooms throughout their full-time education. Progress is reported for speech and language, literacy, socialisation, daily living skills and behaviour. For all the teenagers, there is evidence of progress with age on all the measures except for communication. Communication continued to improve through teenage years for the included children but not for those in special education classrooms. There were no significant differences in overall outcomes for daily living skills or socialisation. However, there were large significant gains in expressive language and literacy skills for those educated in mainstream classrooms. Teenagers educated in mainstream classrooms showed fewer behavioural difficulties. Further, comparison with data published by these authors in an earlier study, showed no improvements in school achievements in special education over a 13 year period in the UK (1986-1999).

Leader-member exchange theory and research : accomplishments and future challenges

Abstract: In the Leader-Member Exchange (LMX) theory of leadership, the quality of the exchange relationship between a leader and a particular member of a work unit, team or organization is the basic unit of analysis (dyad). In this article, we try to answer the question whether research on the various aspects of the exchange processes between leaders and their subordinates is consistent with the theoretical underpinnings of LMX theory. Our focus is on the similarities and differences between the theoretical assumptions of LMX theory and the way the core concepts are elaborated in empirical studies. Although LMX theory has resulted in a number of useful accomplishments, both theoretical and practical, it still faces a number of challenges. The main challenges are to carry out a thorough and consistent refinement of the measuring instruments used, and to gain more insight into the mutual behaviours, attributions, and evaluations which facilitate or inhibit the development of high-quality working relationships.

Alien species and other notable records from a rapid assessment survey of marinas on the south coast of England

Abstract: Arenas, F., Bishop, J.D.D., Carlton, J.T., Dyrynda, P.J., Farnham, W.F., Gonzalez, D.J., Jacobs, M.W., Lambert, C., Lambert, G., Nielsen, S.E., Pederson, J.A., Porter, J.S., Ward, S., Wood, C.A. (2006). Alien species and other notable records from a rapid assessment survey of marinas on the south coast of England. Journal of the Marine Biological Association of the United Kingdom, 86, (6), 1329-1337. Sponsorship: National Science Foundation grant IOB 0407527; Esme Fairbairn Foundation ALIENS project

Muscles of facial expression in the chimpanzee (Pan troglodytes): descriptive, comparative and phylogenetic contexts

Abstract: Facial expressions are a critical mode of non-vocal communication for many mammals, particularly non-human primates. Although chimpanzees (Pan troglodytes) have an elaborate repertoire of facial signals, little is known about the facial expression (i.e. mimetic) musculature underlying these movements, especially when compared with some other catarrhines. Here we present a detailed description of the facial muscles of the chimpanzee, framed in comparative and phylogenetic contexts, through the dissection of preserved faces using a novel approach. The arrangement and appearance of muscles were noted and compared with previous studies of chimpanzees and with prosimians, cercopithecoids and humans. The results showed 23 mimetic muscles in P. troglodytes, including a thin sphincter colli muscle, reported previously only in adult prosimians, a bi-layered zygomaticus major muscle and a distinct risorius muscle. The presence of these muscles in such definition supports previous studies that describe an elaborate and highly graded facial communication system in this species that remains qualitatively different from that reported for other non-human primate species. In addition, there are minimal anatomical differences between chimpanzees and humans, contrary to conclusions from previous studies. These results amplify the importance of understanding facial musculature in primate taxa, which may hold great taxonomic value.

An Empirical Test of the Behaviour Analysis Interview

Abstract: The present experiment is the first empirical test of the Behaviour Analysis Interview (BAI), an interview technique developed by F. E. Inbau, J. E. Reid, J. P. Buckley, & B. C. Jayne (2001) designed to evoke different verbal and non-verbal responses from liars and truth-tellers. Inbau et al. expect liars to be less helpful than truth-tellers in investigations and to exhibit more nervous behaviours. Just the opposite predictions, however, follow from the deception literature, which notes that liars take their credibility less for granted and are therefore more aware of their responses and their impact on others. This suggests that liars' answers should be more helpful than truth-tellers' answers, and liars' non-verbal responses should appear more relaxed than truth-tellers' non-verbal responses. In the present experiment, 40 participants (undergraduate students) lied or told the truth about an event during a BAI interview. The interviews were coded according to Inbau et al.'s guidelines. The results showed that, compared to liars, truth-tellers (a) were more naive and evasive when explaining the purpose of the interview, and (b) were less likely to name someone who they felt certain did not commit the crime. Truth-tellers also exhibited more nervous behaviours. The results were consistent with the predictions of the deception literature, and directly opposed to the predictions of BAI.

Police officers', social workers', teachers' and the general public's beliefs about deception in children, adolescents and adults.

Abstract: Purpose. The present survey examined the beliefs of different occupational groups (police officers, social workers, teachers) and members of the general public about (i) cues to deception in young children (5- to 6-year-olds), adolescents (14- to 15-year-olds) and adults, and (ii) the underlying processes (emotions, cognitive load and attempted verbal and behavioural control), which may explain why cues to deceit do occur. Method. Two hundred and six participants completed a ‘cues to deception’ and ‘processes underlying deception’ questionnaire for three different age groups (young children, adolescents and adults). Results and discussion. The survey revealed that participants believed that liars are nervous, have difficulties in formulating their lies and do not fully endorse their lies. In general, participants associated more cues with deception than seems justified on the basis of deception literature. Participants generally associated the same cues to deceit for all three age groups but, when differences between age groups did emerge, this was most likely to be amongst teachers. Although participants believed that adults control their speech and behaviour more when they lie than adolescents and young children do, this did not result in participants believing that adults exhibit fewer cues to deceit. No major occupational differences emerged, although out of the four participating groups, teachers were most likely to associate cues with deception in young children.