University of Queensland

About: University of Queensland is a education organization based out in Brisbane, Queensland, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 51138 authors who have published 155721 publications receiving 5717659 citations. The organization is also known as: UQ & The University of Queensland.

A mid-term analysis of progress toward international biodiversity targets

Abstract: In 2010, the international community, under the auspices of the Convention on Biological Diversity, agreed on 20 biodiversity-related “Aichi Targets” to be achieved within a decade. We provide a comprehensive mid-term assessment of progress toward these global targets using 55 indicator data sets. We projected indicator trends to 2020 using an adaptive statistical framework that incorporated the specific properties of individual time series. On current trajectories, results suggest that despite accelerating policy and management responses to the biodiversity crisis, the impacts of these efforts are unlikely to be reflected in improved trends in the state of biodiversity by 2020. We highlight areas of societal endeavor requiring additional efforts to achieve the Aichi Targets, and provide a baseline against which to assess future progress.

Objectively Measured Sedentary Time, Physical Activity, and Metabolic Risk: The Australian Diabetes, Obesity and Lifestyle Study (AusDiab)

Abstract: OBJECTIVE —We examined the associations of objectively measured sedentary time and physical activity with continuous indexes of metabolic risk in Australian adults without known diabetes. RESEARCH DESIGN AND METHODS —An accelerometer was used to derive the percentage of monitoring time spent sedentary and in light-intensity and moderate-to-vigorous–intensity activity, as well as mean activity intensity, in 169 Australian Diabetes, Obesity and Lifestyle Study (AusDiab) participants (mean age 53.4 years). Associations with waist circumference, triglycerides, HDL cholesterol, resting blood pressure, fasting plasma glucose, and a clustered metabolic risk score were examined. RESULTS —Independent of time spent in moderate-to-vigorous–intensity activity, there were significant associations of sedentary time, light-intensity time, and mean activity intensity with waist circumference and clustered metabolic risk. Independent of waist circumference, moderate-to-vigorous–intensity activity time was significantly beneficially associated with triglycerides. CONCLUSIONS —These findings highlight the importance of decreasing sedentary time, as well as increasing time spent in physical activity, for metabolic health.

Nimrod/G: an architecture for a resource management and scheduling system in a global computational grid

Abstract: The availability of powerful microprocessors and high-speed networks as commodity components has enabled high-performance computing on distributed systems (wide-area cluster computing). In this environment, as the resources are usually distributed geographically at various levels (department, enterprise or worldwide), there is a great challenge in integrating, coordinating and presenting them as a single resource to the user, thus forming a computational grid. Another challenge comes from the distributed ownership of resources, with each resource having its own access policy, cost and mechanism. The proposed Nimrod/G grid-enabled resource management and scheduling system builds on our earlier work on Nimrod (D. Abramson et al., 1994, 1995, 1997, 2000) and follows a modular and component-based architecture enabling extensibility, portability, ease of development, and interoperability of independently developed components. It uses the GUSTO (GlobUS TOolkit) services and can be easily extended to operate with any other emerging grid middleware services. It focuses on the management and scheduling of computations over dynamic resources scattered geographically across the Internet at department, enterprise or global levels, with particular emphasis on developing scheduling schemes based on the concept of computational economy for a real testbed, namely the Globus testbed (GUSTO).

A mathematical model explains saturating axon guidance responses to molecular gradients

Abstract: Correct wiring is crucial for the proper functioning of the nervous system. Molecular gradients provide critical signals to guide growth cones, which are the motile tips of developing axons, to their targets. However, in vitro, growth cones trace highly stochastic trajectories, and exactly how molecular gradients bias their movement is unclear. Here, we introduce a mathematical model based on persistence, bias, and noise to describe this behaviour, constrained directly by measurements of the detailed statistics of growth cone movements in both attractive and repulsive gradients in a microfluidic device. This model provides a mathematical explanation for why average axon turning angles in gradients in vitro saturate very rapidly with time at relatively small values. This work introduces the most accurate predictive model of growth cone trajectories to date, and deepens our understanding of axon guidance events both in vitro and in vivo.

Brain tumour stem cells

Abstract: The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.