Showing papers by "University of Rajasthan published in 2014"
Betty Abelev1, Luke David Hanratty2, M. Esposito3, Edmundo Javier Garcia-Solis4 +940 more•Institutions (90)
TL;DR: The ALICE experiment at the CERN Large Hadron Collider as mentioned in this paper continuously took data during the first physics campaign of the machine from fall 2009 until early 2013, using proton and lead-ion beams.
Abstract: ALICE is the heavy-ion experiment at the CERN Large Hadron Collider. The experiment continuously took data during the first physics campaign of the machine from fall 2009 until early 2013, using proton and lead-ion beams. In this paper we describe the running environment and the data handling procedures, and discuss the performance of the ALICE detectors and analysis methods for various physics observables.
691 citations
23 Jan 2014
TL;DR: The beam energy and collision centrality dependence of the mean, standard deviation, skewness, and kurtosis of the net-proton multiplicity distributions in Au+Au collisions and the products of moments are found to be significantly below the Skellam expectation and close to expectations based on independent proton and antiproton production.
Abstract: We report the beam energy (root S-NN = 7.7-200 GeV) and collision centrality dependence of the mean (M), standard deviation (sigma), skewness (S), and kurtosis (kappa) of the net-proton multiplicity distributions in Au + Au collisions. The measurements are carried out by the STAR experiment at midrapidity (vertical bar y vertical bar < 0.5) and within the transverse momentum range 0.4 < p(T) < 0.8 GeV/c in the first phase of the Beam Energy Scan program at the Relativistic Heavy Ion Collider. These measurements are important for understanding the quantum chromodynamic phase diagram. The products of the moments, S sigma and K sigma(2), are sensitive to the correlation length of the hot and dense medium created in the collisions and are related to the ratios of baryon number susceptibilities of corresponding orders. The products of moments are found to have values significantly below the Skellam expectation and close to expectations based on independent proton and antiproton production. The measurements are compared to a transport model calculation to understand the effect of acceptance and baryon number conservation and also to a hadron resonance gas model.
432 citations
TL;DR: These measurements provide a valuable tool to extract the freeze-out parameters in heavy-ion collisions by comparing with theoretical models and show nonmonotonic behavior as a function of collision energy.
Abstract: We report the first measurements of the moments-mean (M), variance (sigma(2)), skewness (S), and kurtosis (kappa)-of the net-charge multiplicity distributions at midrapidity in Au + Au collisions at seven energies, ranging from root s(NN) = 7.7 to 200 GeV, as a part of the Beam Energy Scan program at RHIC. The moments are related to the thermodynamic susceptibilities of net charge, and are sensitive to the location of the QCD critical point. We compare the products of the moments, sigma(2)/M, S sigma, and kappa sigma(2), with the expectations from Poisson and negative binomial distributions (NBDs). The S sigma values deviate from the Poisson baseline and are close to the NBD baseline, while the kappa sigma(2) values tend to lie between the two. Within the present uncertainties, our data do not show nonmonotonic behavior as a function of collision energy. These measurements provide a valuable tool to extract the freeze-out parameters in heavy-ion collisions by comparing with theoretical models.
285 citations
TL;DR: In this paper, the authors measured the transverse momentum spectra of pi(+/-), K-+/- and p((p) over bar) up to p(T) = 20 GeV/c at mid-rapidity in pp, peripheral (60-80%) and central (0-5%) Pb-Pb collisions.
276 citations
TL;DR: In this paper, the authors proposed an ultra-light, high-resolution Inner Tracking System (ITS) based on monolithic CMOS pixel detectors for detection of heavy-flavour hadrons, and of thermal photons and low-mass di- electrons emitted by the Quark-Gluon Plasma (QGP) at the CERN LHC (Large Hadron Collider).
Abstract: ALICE (A Large Ion Collider Experiment) is studying the physics of strongly interacting matter, and in particular the properties of the Quark–Gluon Plasma (QGP), using proton–proton, proton–nucleus and nucleus–nucleus collisions at the CERN LHC (Large Hadron Collider). The ALICE Collaboration is preparing a major upgrade of the experimental apparatus, planned for installation in the second long LHC shutdown in the years 2018–2019. A key element of the ALICE upgrade is the construction of a new, ultra-light, high- resolution Inner Tracking System (ITS) based on monolithic CMOS pixel detectors. The primary focus of the ITS upgrade is on improving the performance for detection of heavy-flavour hadrons, and of thermal photons and low-mass di- electrons emitted by the QGP. With respect to the current detector, the new Inner Tracking System will significantly enhance the determination of the distance of closest approach to the primary vertex, the tracking efficiency at low transverse momenta, and the read-out rate capabilities. This will be obtained by seven concentric detector layers based on a 50 μm thick CMOS pixel sensor with a pixel pitch of about 30×30 μm2. This document, submitted to the LHCC (LHC experiments Committee) in September 2013, presents the design goals, a summary of the R&D activities, with focus on the technical implementation of the main detector components, and the projected detector and physics performance.
252 citations
TL;DR: The proton and net-proton results qualitatively resemble predictions of a hydrodynamic model with a first-order phase transition from hadronic matter to deconfined matter, and differ fromHadronic transport calculations.
Abstract: Rapidity-odd directed flow (upsilon 1) measurements for charged pions, protons, and antiprotons near midrapidity (y = 0) are reported in root(S)(NN) = 7.7, 11.5, 19.6, 27, 39, 62.4, and 200 GeVAu+Au collisions as recorded by the STAR detector at the Relativistic Heavy Ion Collider. At intermediate impact parameters, the proton and net-proton slope parameter d upsilon(1) = d upsilon(1)vertical bar (y=0) shows a minimum between 11.5 and 19.6 GeV. In addition, the net-proton d upsilon(1) = d upsilon(1)vertical bar (y=0) changes sign twice between 7.7 and 39 GeV. The proton and net-proton results qualitatively resemble predictions of a hydrodynamic model with a first-order phase transition from hadronic matter to deconfined matter, and differ from hadronic transport calculations.
222 citations
TL;DR: The results of the beam-energy dependence of the charge correlations in Au+Au collisions at midrapidity for center-of-mass energies of 7.7 GeV implies the dominance of hadronic interactions over partonic ones at lower collision energies.
Abstract: Local parity-odd domains are theorized to form inside a quark-gluon plasma which has been produced in high-energy heavy-ion collisions. The local parity-odd domains manifest themselves as charge separation along the magnetic field axis via the chiral magnetic effect. The experimental observation of charge separation has previously been reported for heavy-ion collisions at the top RHIC energies. In this Letter, we present the results of the beam-energy dependence of the charge correlations in Au + Au collisions at midrapidity for center-of-mass energies of 7.7, 11.5, 19.6, 27, 39, and 62.4 GeV from the STAR experiment. After background subtraction, the signal gradually reduces with decreased beam energy and tends to vanish by 7.7 GeV. This implies the dominance of hadronic interactions over partonic ones at lower collision energies.
213 citations
TL;DR: In this paper, the authors measured the nuclear modification factor in Pb-Pb collisions at root(NN)-N-S = 2.76TeV and showed that a contribution to the nuclear modify factor originates from the charm quark (re) combination in the deconfined partonic medium.
206 citations
TL;DR: The first measurement of charmed-hadron (D-0) production via the hadronic decay channel (D0 -> K- + pi(+)) in Au + Au collisions at root(NN)-N-s = 200 GeV with the STAR experiment was reported in this article.
Abstract: We report the first measurement of charmed-hadron (D-0) production via the hadronic decay channel (D-0 -> K- + pi(+)) in Au + Au collisions at root(NN)-N-s = 200 GeV with the STAR experiment. The charm production cross section per nucleon- nucleon collision at midrapidity scales with the number of binary collisions, N-bin, from p + p to central Au + Au collisions. The D-0 meson yields in central Au + Au collisions are strongly suppressed compared to those in p + p scaled by N-bin, for transverse momenta p(T) > 3 GeV/c, demonstrating significant energy loss of charm quarks in the hot and dense medium. An enhancement at intermediate p(T) is also observed. Model calculations including strong charm-medium interactions and coalescence hadronization describe our measurements.
199 citations
TL;DR: The ALICE Collaboration is preparing a major upgrade of the experimental apparatus, planned for installation in the second long LHC shutdown in the years 2018-2019 as mentioned in this paper, which will be achieved by an increase of the Pb-Pb instant luminosity up to 6×1027 cm−2s−1 and running the ALICE detector with the continuous readout at the 50 kHz event rate.
Abstract: ALICE (A Large Ion Collider Experiment) is studying the physics of strongly interacting matter, and in particular the properties of the Quark–Gluon Plasma (QGP), using proton–proton, proton–nucleus and nucleus–nucleus collisions at the CERN LHC (Large Hadron Collider). The ALICE Collaboration is preparing a major upgrade of the experimental apparatus, planned for installation in the second long LHC shutdown in the years 2018–2019. These plans are presented in the ALICE Upgrade Letter of Intent, submitted to the LHCC (LHC experiments Committee) in September 2012. In order to fully exploit the physics reach of the LHC in this field, high-precision measurements of the heavy-flavour production, quarkonia, direct real and virtual photons, and jets are necessary. This will be achieved by an increase of the LHC Pb–Pb instant luminosity up to 6×1027 cm−2s−1 and running the ALICE detector with the continuous readout at the 50 kHz event rate. The physics performance accessible with the upgraded detector, together with the main detector modifications, are presented.
196 citations
TL;DR: Graphene quantum dots are synthesized from bio-waste and are further modified to produce amine-terminated GQDs (Am-GQDs) which have higher dispersibility and photoluminescence intensity than those of G QDs.
Abstract: Graphene quantum dots (GQDs) are synthesized from bio-waste and are further modified to produce amine-terminated GQDs (Am-GQDs) which have higher dispersibility and photoluminescence intensity than those of GQDs. A strong fluorescence quenching of Am-GQDs (switch-off) is observed for a number of metal ions, but only for the Ag(+) ions is the original fluorescence regenerated (switch-on) upon addition of L-cysteine.
TL;DR: In this article, the second harmonic two-particle cumulants are found to decrease with multiplicity, characteristic of a dominance of fewparticle correlations in p-Pb collisions.
Abstract: Measurements of multiparticle azimuthal correlations (cumulants) for charged particles in p-Pb at √sNN√=5.02 TeV and Pb-Pb at √sNN=2.76 TeV collisions are presented. They help address the question of whether there is evidence for global, flowlike, azimuthal correlations in the p-Pb system. Comparisons are made to measurements from the larger Pb-Pb system, where such evidence is established. In particular, the second harmonic two-particle cumulants are found to decrease with multiplicity, characteristic of a dominance of few-particle correlations in p-Pb collisions. However, when a |Δη| gap is placed to suppress such correlations, the two-particle cumulants begin to rise at high multiplicity, indicating the presence of global azimuthal correlations. The Pb-Pb values are higher than the p-Pb values at similar multiplicities. In both systems, the second harmonic four-particle cumulants exhibit a transition from positive to negative values when the multiplicity increases. The negative values allow for a measurement of v2{4} to be made, which is found to be higher in Pb-Pb collisions at similar multiplicities. The second harmonic six-particle cumulants are also found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find v2{4}≃v2{6}≠0 which is indicative of a Bessel-Gaussian function for the v2 distribution. For very high-multiplicity Pb-Pb collisions, we observe that the four- and six-particle cumulants become consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and Pb-Pb are measured. These are found to be similar for overlapping multiplicities, when a |Δη|>1.4 gap is placed.
TL;DR: In this article, the production of prompt charmed mesons relative to the reaction plane was measured in Pb-Pb collisions at a center-of-mass energy per nucleon-nucleon collision of √sNN=2.76TeV with the ALICE detector at the CERN Large Hadron Collider.
Abstract: The production of the prompt charmed mesons D0, D+, and D*+ relative to the reaction plane was measured in Pb-Pb collisions at a center-of-mass energy per nucleon-nucleon collision of √sNN=2.76TeV with the ALICE detector at the CERN Large Hadron Collider. D mesons were reconstructed via their hadronic decays at central rapidity in the transverse-momentum (p_T) interval 2–16 GeV/c. The azimuthal anisotropy is quantified in terms of the second coefficient v2 in a Fourier expansion of the D-meson azimuthal distribution and in terms of the nuclear modification factor R_AA, measured in the direction of the reaction plane and orthogonal to it. The v2 coefficient was measured with three different methods and in three centrality classes in the interval 0%–50%. A positive v2 is observed in midcentral collisions (30%–50% centrality class), with a mean value of 0.204+0.099−0.036 (tot. unc.) in the interval 2
TL;DR: The nuclear modification factor R_{pPb), quantifying the D-meson yield in p-Pb collisions relative to the yield in pp collisions scaled by the number of binary nucleon-nucleon collisions, is compatible within the 15%-20% uncertainties with unity in the transverse momentum interval 1
Abstract: The p_{T}-differential production cross sections of the prompt charmed mesons D^{0}, D^{+}, D^{*+}, and D_{s}^{+} and their charge conjugate in the rapidity interval -0.96
TL;DR: The achievement and current status of mycoremediation technology based on mushroom cultivation for the remediation of waste is reviewed and the importance of mushroom as product is emphasized.
Abstract: Mushroom has been used for consumption as product for a long time due to their flavor and richness in protein. Mushrooms are also known as mycoremediation tool because of their use in remediation of different types of pollutants. Mycoremediation relies on the efficient enzymes, produced by mushroom, for the degradation of various types of substrate and pollutants. Besides waste degradation, mushroom produced a vendible product for consumption. However, sometimes they absorb the pollutant in their mycelium (biosorption process) and cannot be consumed due to absorbed toxicants. This article reviews the achievement and current status of mycoremediation technology based on mushroom cultivation for the remediation of waste and also emphasizes on the importance of mushroom as product. This critical review is also focused on the safety aspects of mushroom cultivation on waste.
TL;DR: In this article, a review summarizes the literature reported thus far and envisions plants as emerging sources of nanofactories along with applications, the mechanism behind phytosynthesis of nanoparticles and the mechanism of antibacterial action.
Abstract: In recent years, nanoscience and nanotechnology have emerged as a new area of fundamental science and are receiving global attention due to their extensive applications. Conventionally nanoparticles were manufactured by physical and chemical techniques. The recent development and implementation of new technologies have led to a new trend, the nano-revolution unfolding the role of plants in bio- and green synthesis of nanoparticles which seems to have drawn a quite unequivocal attention to the synthesis of stable nanoparticles. Although nanoparticles can be synthesized through many conventional methods, biological route of the synthesis is more competent than the physical and chemical techniques. Biologically synthesized nanoparticles have enjoyed an upsurge of applications in various sectors. Hence, the present study envisions biosynthesis of nanoparticles from plants which are emerging as nanofactories. Hence, the present review summarizes the literature reported thus far and envisions plants as emerging sources of nanofactories along with applications, the mechanism behind phytosynthesis of nanoparticles and the mechanism of antibacterial action of nanoparticles.
TL;DR: The present review summarizes the research finding of a large number of research papers on the reproductive functions especially on hypothalmo-pituitary-gonadal axis, spermatogenesis, histopathology of testis, synthesis and secretion of testosterone, sperm quality, ejaculatory function and fertility both in diabetic men and experimental diabetic animals.
Abstract: Diabetes mellitus (DM) represents one of the greatest threats to human health all over the world. The incidence of DM is rising rapidly also including children and young persons of reproductive age. Diabetes has been associated with reproductive impairment in both men and women. Diabetes may affect male reproductive functions at multiple levels as a result of its effects on the endocrine control of spermatogenesis, steroidogenesis, sperm maturation, impairment of penile erection and ejaculation. A large number of studies both on diabetic men and experimental diabetic animals have been published on the impact of DM on male reproductive functions during the past few years but many of them have conflicting results. The present review summarizes the research finding of a large number of research papers on the reproductive functions especially on hypothalmo-pituitary-gonadal axis, spermatogenesis, histopathology of testis, synthesis and secretion of testosterone, sperm quality, ejaculatory function and fertility both in diabetic men and experimental diabetic animals.
TL;DR: A very large and integrated detrital zircon database that provides constraints on the age of the Upper Vindhyan sequence and its relationship to the nearby Marwar Supergroup is provided in this article.
TL;DR: In this article, the presence of a ∼85,000 km2 radiating dyke swarm with a fanning angle of 65° is confirmed within Peninsular India at 1.88°Ga.
01 Mar 2014
TL;DR: In this article, the transverse momentum spectra of a radial jet in Pb-Pb collisions at √sNN = 2.76TeV is measured and the anti-k T jet algorithm with jet resolution parameters R of 0.2 and 0.3 in pseudo-rapidity |η| < 0.5.
Abstract: A measurement of the transverse momentum spectra of jets in Pb-Pb collisions at √sNN = 2.76TeV is reported. Jets are reconstructed from charged particles using the anti-k T jet algorithm with jet resolution parameters R of 0.2 and 0.3 in pseudo-rapidity |η| < 0.5. The transverse momentum p T of charged particles is measured down to 0.15 GeV/c which gives access to the low p T fragments of the jet. Jets found in heavy-ion collisions are corrected event-by-event for average background density and on an inclusive basis (via unfolding) for residual background fluctuations and detector effects. A strong suppression of jet production in central events with respect to peripheral events is observed. The suppression is found to be similar to the suppression of charged hadrons, which suggests that substantial energy is radiated at angles larger than the jet resolution parameter R = 0.3 considered in the analysis. The fragmentation bias introduced by selecting jets with a high p T leading particle, which rejects jets with a soft fragmentation pattern, has a similar effect on the jet yield for central and peripheral events. The ratio of jet spectra with R = 0.2 and R = 0.3 is found to be similar in Pb-Pb and simulated PYTHIA pp events, indicating no strong broadening of the radial jet structure in the reconstructed jets with R < 0.3. [Figure not available: see fulltext.] © 2014 The Author(s).
TL;DR: The analysis is based on a data sample corresponding to an integrated luminosity of 1.35 pb and the results are compared to measurements performed by other LHC experiments and to theoretical models.
Abstract: The inclusive production cross sections at forward rapidity of [Formula: see text], [Formula: see text], [Formula: see text](1S) and [Formula: see text](2S) are measured in [Formula: see text] collisions at [Formula: see text] with the ALICE detector at the LHC. The analysis is based on a data sample corresponding to an integrated luminosity of 1.35 pb[Formula: see text]. Quarkonia are reconstructed in the dimuon-decay channel and the signal yields are evaluated by fitting the [Formula: see text] invariant mass distributions. The differential production cross sections are measured as a function of the transverse momentum [Formula: see text] and rapidity [Formula: see text], over the ranges [Formula: see text] GeV/c for [Formula: see text], [Formula: see text] GeV/c for all other resonances and for [Formula: see text]. The measured cross sections integrated over [Formula: see text] and [Formula: see text], and assuming unpolarized quarkonia, are: [Formula: see text] [Formula: see text]b, [Formula: see text] [Formula: see text]b, [Formula: see text] nb and [Formula: see text] nb, where the first uncertainty is statistical and the second one is systematic. The results are compared to measurements performed by other LHC experiments and to theoretical models.
TL;DR: In this article, the authors reported measurements of Upsilon meson production in p + p, d + Au, and Au + Au collisions using the STAR detector at RHIC.
23 Apr 2014
TL;DR: In this article, the same and opposite sign charge-dependent azimuthal correlations with respect to the event plane in Au+ Au collisions at root(S)(NN) = 200 GeV were investigated.
Abstract: A study is reported of the same-and opposite-sign charge-dependent azimuthal correlations with respect to the event plane in Au+ Au collisions at root(S)(NN) = 200 GeV. The charge multiplicity asymmetries between the up/down and left/right hemispheres relative to the event plane are utilized. The contributions from statistical fluctuations and detector effects were subtracted from the (co-) variance of the observed charge multiplicity asymmetries. In the mid-to most-central collisions, the same- (opposite-) sign pairs are preferentially emitted in back-to-back (aligned on the same-side) directions. The charge separation across the event plane, measured by the difference, Delta, between the like-and unlike-sign up/down-left/right correlations, is largest near the event plane. The difference is found to be proportional to the event-by-event final-state particle ellipticity (via the observed second order harmonic nu(obs)(2)), where Delta = [ 1.3 +/- 1.4( stat)(-1.0)(+4.0)(syst)] x 10(-5) + [3.2 +/- 0.2(stat)(- 0.3)(+0.4)(syst)] x 10(-3)v(2)(obs) for 20- 40% Au + Au collisions. The implications for the proposed chiral magnetic effect are discussed.
TL;DR: In this paper, a strong suppression of the inclusive Υ (1S) yield is observed with respect to pp collisions scaled by the number of independent nucleon- nucleon collisions.
TL;DR: Measurements of single- and double-spin asymmetries for W^{±} and Z/γ^{*} boson production in longitudinally polarized p+p collisions at sqrt[s]=510 GeV by the STAR experiment at RHIC show a preference for a sizable, positive up antiquark polarization in the range 0.05.
Abstract: We report measurements of single- and double-spin asymmetries for W-+/- and Z/gamma* boson production in longitudinally polarized p + p collisions at root s = 510 GeV by the STAR experiment at RHIC. The asymmetries for W-+/- were measured as a function of the decay lepton pseudorapidity, which provides a theoretically clean probe of the proton's polarized quark distributions at the scale of the W mass. The results are compared to theoretical predictions, constrained by polarized deep inelastic scattering measurements, and show a preference for a sizable, positive up antiquark polarization in the range 0.05 < x < 0.2.
TL;DR: In 2013, the Large Hadron Collider provided proton-lead and lead-proton collisions at the center-of-mass energy per nucleon pair √ sNN = 5.02 TeV as mentioned in this paper.
Abstract: In 2013, the Large Hadron Collider provided proton-lead and lead-proton collisions at the center-of-mass energy per nucleon pair √ sNN = 5.02 TeV. Van der Meer scans were performed for both configurations of colliding beams, and the cross section was measured for two reference processes, based on particle detection by the T0 and V0 detectors, with pseudo-rapidity coverage 4.6 < η < 4.9, −3.3 < η < −3.0 and 2.8 < η < 5.1, −3.7 < η < −1.7, respectively. Given the asymmetric detector acceptance, the cross section was measured separately for the two configurations. The measured visible cross sections are used to calculate the integrated luminosity of the proton-lead and lead-proton data samples, and to indirectly measure the cross section for a third, configuration-independent, reference process, based on neutron detection by the Zero Degree Calorimeters.
TL;DR: The results imply the existence of at least two mechanisms of inhibition of SNARE-dependent membrane fusion: at high concentrations, nonaggregated α-Syn inhibits docking by binding acidic lipids but not v-SNARE; on the other hand, at much lower concentrations, large α- Syn oligomers inhibit via a mechanism that requires v- SNARE interaction.
Abstract: α-Synuclein (α-Syn), a major component of Lewy body that is considered as the hallmark of Parkinson’s disease (PD), has been implicated in neuroexocytosis. Overexpression of α-Syn decreases the neurotransmitter release. However, the mechanism by which α-Syn buildup inhibits the neurotransmitter release is still unclear. Here, we investigated the effect of nonaggregated α-Syn on SNARE-dependent liposome fusion using fluorescence methods. In ensemble in vitro assays, α-Syn reduces lipid mixing mediated by SNAREs. Furthermore, with the more advanced single-vesicle assay that can distinguish vesicle docking from fusion, we found that α-Syn specifically inhibits vesicle docking, without interfering with the fusion. The inhibition in vesicle docking requires α-Syn binding to acidic lipid containing membranes. Thus, these results imply the existence of at least two mechanisms of inhibition of SNARE-dependent membrane fusion: at high concentrations, nonaggregated α-Syn inhibits docking by binding acidic lipids bu...
TL;DR: In this paper, a significant suppression of pT-integrated J/ψ production is observed in central Au+Au events at the BNL Relativistic Heavy Ion Collider.
Abstract: The J/ψ pT spectrum and nuclear modification factor (RAA) are reported for pT<5GeV/c and |y|<1 from 0% to 60% central Au+Au and Cu+Cu collisions at √sNN=200GeV at STAR. A significant suppression of pT-integrated J/ψ production is observed in central Au+Au events. The Cu+Cu data are consistent with no suppression, although the precision is limited by the available statistics. RAA in Au+Au collisions exhibits a strong suppression at low transverse momentum and gradually increases with pT. The data are compared to high-pT STAR results and previously published BNL Relativistic Heavy Ion Collider results. Comparing with model calculations, it is found that the invariant yields at low pT are significantly above hydrodynamic flow predictions but are consistent with models that include color screening and regeneration.
TL;DR: In this article, the authors used three-pion cumulant correlations to measure the size of the particle production region at freeze-out at the LHC with ALICE.
TL;DR: Results suggest that the antioxidant and hepatoprotective activities of M. oleifera leaves are possibly related to the free radical scavenging activity which might be due to the presence of total phenolics and flavonoids in the extract and/or the purified compounds β-sitosterol, quercetin and kaempferol, which were isolated from the ethanol extract of M.'silymarin.
Abstract: The antioxidant and hepatoprotective activities of the extract of Moringa oleifera leaves were investigated against CCl4-induced hepatotoxicity in rats. Hepatotoxic rats were treated with ethanol extract of Moringa oleifera for a period of 60 days at the following three dose levels; 100, 200 and 400 mg/kg body weight/day, orally. The activities were studied by assaying the serum marker enzymes like SGOT, SGPT, GGT, LDH, ALP, ACP, as well as total bilirubin, total protein and albumin in serum concomitantly with the activities of LPO, SOD, CAT, GSH, GR and GPx in liver. The activities of all parameters registered a significant (p ≤ 0.001) alteration in CCl4 treated rats, which were significantly recovered towards an almost normal level in rats co-administered with M. oleifera extract in a dose-dependent manner. All the biochemical investigations were confirmed by the histopathological observations and compared with the standard drug. silymarin. Results suggest that the antioxidant and hepatoprotective activities of M. oleifera leaves are possibly related to the free radical scavenging activity which might be due to the presence of total phenolics and flavonoids in the extract and/or the purified compounds β-sitosterol, quercetin and kaempferol, which were isolated from the ethanol extract of M. oleifera leaves.