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Institution

University of Rajasthan

EducationJaipur, India
About: University of Rajasthan is a education organization based out in Jaipur, India. It is known for research contribution in the topics: Chemical shift & Derivative (chemistry). The organization has 15058 authors who have published 15733 publications receiving 117400 citations. The organization is also known as: Rajasthan University.


Papers
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Journal ArticleDOI
TL;DR: Analysis of various docked complexes revealed that the H-bonds and cation-pi bonds do not have significant contribution to the binding interactions and despite its large size, VLB remains in relaxed conformation and fits in the hydrophobic regions on the receptors.
Abstract: Vinblastine (VLB), a cytotoxic alkaloid is used extensively against various cancer types and the crystal structure of its tubulin complex is already known. Multitarget affinity of vinblastine has been investigated and the nature of binding with biological receptors namely, duplex DNA and Human serum albumin (HSA) has been compared to the binding characteristics of its known complex with natural high affinity receptor tubulin using molecular docking and QM-MM calculations. VLB is found to interact with DNA as well as HSA protein, though, with weaker affinity as compared to tubulin. Analysis of various docked complexes revealed that the H-bonds and cation-pi bonds do not have significant contribution to the binding interactions and despite its large size, VLB remains in relaxed conformation and fits in the hydrophobic regions on the receptors.

41 citations

Journal ArticleDOI
Shreyasi Acharya1, Dagmar Adamová2, Souvik Priyam Adhya1, Alexander Adler3  +1036 moreInstitutions (103)
TL;DR: In this article, the results of the ALICE detector at the Large Hadron Collider (LHC) are reported for the production of D mesons at mid-rapidity ( $|y|<0.5$ ) via their hadronic decay channels.
Abstract: The measurements of the production of prompt ${{\mathrm{D}}^0}$ , ${{\mathrm{D}}^+}$ , ${{\mathrm{D}}^{*+}}$ , and ${{\mathrm{D}}^+_{\mathrm{s}}}$ mesons in proton–proton (pp) collisions at $\sqrt{s}=5.02~\mathrm {TeV}$ with the ALICE detector at the Large Hadron Collider (LHC) are reported. D mesons were reconstructed at mid-rapidity ( $|y|<0.5$ ) via their hadronic decay channels $\mathrm{D}^0 \rightarrow {\mathrm{K}}^-\pi ^+$ , $\mathrm{D}^+\rightarrow {\mathrm{K}}^-\pi ^+\pi ^+$ , ${\mathrm{D}}^{*+} \rightarrow {\mathrm{D}}^0 \pi ^+ \rightarrow {\mathrm{K}}^- \pi ^+ \pi ^+$ , ${{\mathrm{D}}^{+\mathrm{s}}\rightarrow \phi \pi ^+\rightarrow {\mathrm{K}}^{+} {\mathrm{K}}^{-} \pi ^{+}}$ , and their charge conjugates. The production cross sections were measured in the transverse momentum interval $0

41 citations

Journal ArticleDOI
TL;DR: This research established higher PHAs production by solid-state fermentation through sonication and mono-solvent extraction and identified a valuable polymer PHB-co-PHV, which was identified as a valuablepolymethicone polymer and its crystallinity & thermostability nature was validated.

41 citations

Journal ArticleDOI
TL;DR: Direct regeneration via leaf explants will be useful for Agrobacterium-mediated genetic transformation, and will facilitate pathway manipulation using metabolic engineering for bioactive withanolides.
Abstract: A micropropagation system through leaf explant culture has been developed for Withania coagulans. Shoot bud proliferation occurred through both adventitious and de novo routes depending on the hormonal regime of the culture medium. Green compact nodular organogenic callus developed on Murashige and Skoog (MS) medium supplemented with 2.3 μM kinetin (Kn) and lower levels of 6–benzyladenine (BA) (13.3 μM) while multiple adventitious shoot bud differentiation occurred on medium fortified with 2.3 μM kinetin (Kn) and higher levels of BA (22.2 μM). Shoot buds were transferred to proliferation medium containing 2.2 μM BA, 2.3 μM Kn, and 3.9 μM phloroglucinol (PG) for further growth and development of shoot system. Elongated shoots were rooted using a two-step procedure involving pulse treatment of 7 days in a medium containing 71.6 μM choline chloride (CC) and 3.9 μM PG and then transferred to rooting medium containing ½ MS, 1.2 μM IBA, 3.6 μM PAA, and 14.3 μM CC for 3 weeks. Well-rooted plants were transferred to a greenhouse for hardening and further growth. Random amplification of polymorphic DNA (RAPD) showed monomorphic bands in all the plants thereby confirming clonality of the regenerants. Thin layer chromatography (TLC) showed the presence of withanolides in the regenerated plants. Quantification through reverse-phase HPLC revealed increased concentration of withanolides in the regenerated plants compared to the field-grown mother plant. Accumulation of withaferin A and withanolide A increased up to twofold and that of withanone up to tenfold. Direct regeneration via leaf explants will be useful for Agrobacterium-mediated genetic transformation, and will facilitate pathway manipulation using metabolic engineering for bioactive withanolides.

41 citations

Journal ArticleDOI
01 Apr 2012-Facies
TL;DR: Stable isotope analyses of 61 diagenetically unaltered belemnite rostra from the Middle to Late Jurassic of the Kachchh Basin of western India suggest stable paleotemperatures across the Callovian-Oxfordian boundary.
Abstract: Stable isotope analyses of 61 diagenetically unaltered belemnite rostra from the Middle to Late Jurassic of the Kachchh Basin of western India suggest stable paleotemperatures across the Callovian-Oxfordian boundary (~14°C). Only at the end of the Middle Oxfordian water temperatures drop for more than 3°C before reaching again higher values during the Kimmeridgian (~12.3°C). The data do not support polar glaciations proposed for the Middle to Late Jurassic transition, which necessarily would have led to a global temperature and sea-level minimum at the boundary. Callovian to Oxfordian rocks in the Kachchh Basin point to a gradual shallowing corresponding to a slight fall in relative sea level. However, the magnitude of this regression is comparatively small, and the sea-level minimum is reached in the late Early Oxfordian and not close to the boundary. Results from the Kachchh Basin therefore, imply almost stable climatic conditions during the Middle to Late Jurassic transition and do not show any evidence for polar glaciations.

41 citations


Authors

Showing all 15080 results

NameH-indexPapersCitations
Rakesh K. Jain2001467177727
J. Pluta12065952025
Sudhir Raniwala11359144168
Rashmi Raniwala11357944076
Sanjay Jain10388146880
Mirko Planinic9446731957
Manish Sharma82140733361
Nikola Poljak7839320795
Hari M. Srivastava76112642635
Radhey S. Gupta7137718078
Ashwani Kumar6670318099
Amit Kumar65161819277
Rashmi Gupta5242850962
Allan R. Oseroff481217029
Vinod K. Aswal465569917
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20233
202233
2021218
2020242
2019163
2018143