Institution
University of Rajasthan
Education•Jaipur, India•
About: University of Rajasthan is a education organization based out in Jaipur, India. It is known for research contribution in the topics: Chemical shift & Derivative (chemistry). The organization has 15058 authors who have published 15733 publications receiving 117400 citations. The organization is also known as: Rajasthan University.
Topics: Chemical shift, Derivative (chemistry), Porphyrin, Magnetic susceptibility, Magnetic anisotropy
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this article, a single phase wurtzite type hexagonal crystal structure of the synthesized Li doped ZnO nanoparticles was identified from the Rietveld profile refinement of the powder XRD patterns and HRTEM & SAED analysis.
37 citations
••
TL;DR: Three alkaloids were extracted from various parts of S. dulcamara and screened for their antibacterial activity and inhibited the growth of E. coli and S. aureus, but no significant activity was observed against E. aerogenes.
37 citations
••
37 citations
••
TL;DR: Out of the analyzed pesticides, the concentration of p,p'-DDT and its metabolites was higher in all the subjects, but dieldrin was found to be significantly high in the hypothyroid women, and the correlation analysis for d yieldrin and depleted T4 levels in hypothyroxine women elicited an inverse relationship between them.
37 citations
••
TL;DR: This study examined the expression and potential to promote humoral immune responses of a novel CTA, A-kinase anchor protein 4 (AKAP4), among 38 ovarian carcinoma patients and found that AKAP4 was expressed at both the mRNA and protein levels in 89% of ovarian carcinomas tissue specimens but not in 21 matched adjacent non-cancerous tissues.
Abstract: Ovarian cancer is one of the neoplasms affecting the reproductive tract associated with high mortality rate because of limited therapeutic options and an elevated incidence of chemoresistance and recurrence. In this context, immunotherapy may constitute a promising approach to improve survival rates and clinical outcome, raising the need for specific target antigens. Cancer-testis antigens (CTAs) are considered promising candidates in this sense because they are aberrant expressed by various malignancies but not by non-transformed tissue, with the exception of testes. Here, we examined the expression and potential to promote humoral immune responses of a novel CTA, A-kinase anchor protein 4 (AKAP4), among 38 ovarian carcinoma patients. Our results reveal that AKAP4 was expressed at both the mRNA and protein levels in 89% (34/38) of ovarian carcinoma tissue specimens but not in 21 matched adjacent non-cancerous tissues. In addition, a humoral response against AKAP4 was detected in 58% (22/38) of ovarian carcinoma patients by ELISA. In particular, 65% (22/34) patients bearing an AKAP4-expressing tumor exhibited circulating anti-AKAP4 antibodies. Interestingly, the majority of specimens were categorized as ovarian serous adenocarcinoma and serous papillary carcinoma, of which 93% (28/30) and 100% (6/6), respectively, expressed AKAP4. A humoral response against AKAP4 was detected in 79% (19/24) and 67% (4/6) of ovarian serous adenocarcinoma and serous papillary carcinoma patients, respectively. The presence of circulating anti-AKAP4 antibodies suggests the AKAP4 is highly immunogenic in ovarian serous carcinoma patients. Our study lays the foundations for exploring AKAP4 as a potential target for the immunotherapy of ovarian cancer.
37 citations
Authors
Showing all 15080 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rakesh K. Jain | 200 | 1467 | 177727 |
J. Pluta | 120 | 659 | 52025 |
Sudhir Raniwala | 113 | 591 | 44168 |
Rashmi Raniwala | 113 | 579 | 44076 |
Sanjay Jain | 103 | 881 | 46880 |
Mirko Planinic | 94 | 467 | 31957 |
Manish Sharma | 82 | 1407 | 33361 |
Nikola Poljak | 78 | 393 | 20795 |
Hari M. Srivastava | 76 | 1126 | 42635 |
Radhey S. Gupta | 71 | 377 | 18078 |
Ashwani Kumar | 66 | 703 | 18099 |
Amit Kumar | 65 | 1618 | 19277 |
Rashmi Gupta | 52 | 428 | 50962 |
Allan R. Oseroff | 48 | 121 | 7029 |
Vinod K. Aswal | 46 | 556 | 9917 |