University of Rajasthan

About: University of Rajasthan is a education organization based out in Jaipur, India. It is known for research contribution in the topics: Chemical shift & Derivative (chemistry). The organization has 15058 authors who have published 15733 publications receiving 117400 citations. The organization is also known as: Rajasthan University.

Increased variance in blood pressure distribution and changing hypertension prevalence in an urban Indian population.

Abstract: The objective of the study was to determine trends in age-specific blood pressure (BP) distribution and hypertension prevalence in an urban Indian population. In successive hypertension epidemiological studies (1995 and 2002), randomly selected 2212 subjects (1412 men, 797 women) in the first and 1123 subjects (550 men, 573 women) in the second study were evaluated. BP was measured using World Health Organization guidelines and hypertension diagnosed using the American Joint National Committee-VI report. Age-specific BP levels in the first and the second study were determined and compared. The mean values of systolic and diastolic BP were not significantly different in various age groups in the first and the second studies. There was an increased variance in the second study as denoted by the significant increase in standard deviations and coefficients of variation in systolic as well as diastolic BP levels at age groups > or =50 years in men and > or =40 years in women (P or =140/> or =90 mmHg) in the first study was 29.5% (men) and 33.5% (women), and in the second study was 30.0% (men) and 30.3% (women) (P=NS). In the second as compared to the first study, there was decrease in age-adjusted prevalence of stage I hypertension (men 16.8 vs 24.9%, women 15.4 vs 27.5%), and increase in stage II hypertension (men 11.7 vs 2.8%, women 18.8 vs 3.1%), and combined stage II and III hypertension (men 13.5 vs 4.7%, women 16.7 vs 6.0%) (P<0.01). This change was associated with greater prevalence of obesity in the second study. In conclusion, increased systolic and diastolic BP dispersion over a 7-year period in this urban population is associated with unchanged hypertension prevalence, decline in stage I hypertension and upsurge in more severe grades. Increasing environmental factors, particularly obesity, appear important.

Metalated 1, 3‐Azaphospholes: η1‐(1H‐1, 3‐Benzazaphosphole‐P)M(CO)5 and μ2‐[(1, 3‐Benzazaphospholide‐P)(cyclopentadienide)nickel] Complexes

Abstract: 1H-1, 3-Benzazaphospholes react with M(CO)5(THF) (M = Cr, Mo, W) to give thermally and relatively air stable η1-(1H-1, 3-Benzazaphosphole-P)M(CO)5 complexes. The 1H- and 13C-NMR-data are in accordance with the preservation of the phosphaaromatic π-system of the ligand. The strong upfield 31P coordination shift, particularly of the Mo and W complexes, forms a contrast to the downfield-shifts of phosphine-M(CO)5 complexes and classifies benzazaphospholes as weak donor but efficient acceptor ligands. Nickelocene reacts as organometallic species with metalation of the NH-function. The resulting ambident 1, 3-benzazaphospholide anions prefer a μ2-coordination of the η5-CpNi-fragment at phosphorus to coordination at nitrogen or a η3-heteroallyl-η5-CpNi-semisandwich structure. This is shown by characteristic NMR data and the crystal structure analysis of a η5-CpNi-benzazaphospholide. The latter is a P-bridging dimer with a planar Ni2P2 ring and trans-configuration of the two planar heterocyclic phosphido ligands arranged perpendicular to the four-membered ring. Metallierte 1, 3-Azaphosphole: η1-(1H-1, 3-Benzazaphosphol-P)M(CO)5 und μ2-[(1, 3-Benzazaphospholid-P)(cyclopentadienid)nickel] Komplexe 1H-1, 3-Benzazaphosphole reagieren mit M(CO)5(THF) (M = Cr, Mo, W) zu thermisch und zumindest kurzzeitig luftstabilen η1-(1H-1, 3-Benzazaphosphol-P)M(CO)5-Komplexen. Die 1H- und 13C-NMR-Daten sind mit dem Erhalt des phosphaaromatischen π-Systems im Liganden im Einklang. Die starke 31P-Koordinationsverschiebung zu hohem Feld, vor allem der Mo- und W-Komplexe, steht im Gegensatz zur Koordinationsverschiebung zu tiefem Feld, beobachtet bei Phosphin-M(CO)5 Komplexen, und verweist auf schwache Donator-, aber gute Akzeptoreigenschaften der Liganden. Nickelocen reagiert als Ubergangsmetallorganyl unter Metallierung der NH-Funktion. Die resultierenden ambidenten 1, 3-Benzazaphospholid-Anionen bevorzugen eine μ2-Koordination des η5-CpNi-Fragments am Phosphor gegenuber N-Koordination oder einer η3-Heteroallyl-η5-CpNi-Semisandwich-Struktur. Dies wird durch charakteristische NMR-Daten und die Ergebnisse der Strukturuntersuchung an Einkristallen eines η5-CpNi-benzazaphospholids belegt. Letzteres kristallisiert mit Benzol und bildet ein P-Bruckendimer mit planarem Ni2P2 Ring und trans-Konfiguration der beiden senkrecht zum Vierring angeordneten planaren heterocyclischen Phosphidoliganden.

Cancer chemopreventive effects of the flavonoid-rich fraction isolated from papaya seeds.

Abstract: Intervention to decelerate, arrest, or reverse the process of carcinogenesis by the use of either natural or synthetic agents individually or in combination has emerged as a promising and pragmatic medical approach to reduce cancer risk. In the present study, we examined the cancer chemopreventive potential of a flavonoid-rich fraction isolated from the seeds of Carica papaya, a plant traditionally referred to as papaw. The flavonoid-enriched benzene fraction of the aqueous extract exerted its anticancer properties in vitro through cytoprotection, antioxidative and antiinflammatory mechanisms and genoprotection in response to isocyanate-induced carcinogenicity. Medium-term anticarcinogenicity and 2-stage skin papillomagenesis studies conducted in benzopyrene-induced lung carcinogenesis and 7,12-dimethyl benz(a)anthracene-mediated skin papillomagenesis mouse models further validated our in vitro observations. This is the first demonstration of chemopreventive activities of papaya seed products, however, further studies to understand the subtle targets of intracellular signaling pathways, pharmacological profile and toxicological safety of this bioactive fraction are essential to pave the way for successful clinical translation. Our study supports the inverse association between dietary flavonoid intake and cancer risk.

Base catalyzed multicomponent synthesis of spiroheterocycles with fused heterosystems

Abstract: Structurally diverse spiroheterocycles incorporating medicinally privileged heterosystems have been synthesized by a simple and convenient synthesis involving triethylamine catalyzed multicomponent domino reaction of 2-aminobenzothiazoles with isatin and cyclic 1,3-diketones.