University of Rajasthan

About: University of Rajasthan is a education organization based out in Jaipur, India. It is known for research contribution in the topics: Chemical shift & Derivative (chemistry). The organization has 15058 authors who have published 15733 publications receiving 117400 citations. The organization is also known as: Rajasthan University.

Amelioration of radiation-induced hematological and biochemical alterations in Swiss albino mice by Panax ginseng extract.

Abstract: Background This study was carried out to observe the radioprotective effect of Panax ginseng root extract (PGE) against radiation-induced hematological and biochemical alterations in blood and liver of mice Materials and methods Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of PGE to study the quantitative and qualitative alterations in the blood and liver Results Radiation exposure resulted in a significant decline (P < 001) in erythrocyte count, hemoglobin (Hb), and hematocrit (Hct) in peripheral blood Maximum changes in all the parameters were observed on day 3 after irradiation In contrast, PGE-pretreated irradiated animals showed a significant increase in erythrocyte, Hct, and Hb values compared with irradiated controls Furthermore, a significant elevation in lipid peroxidation level over normal was recorded in irradiated control mice, whereas this increase was considerably lesser in PGE pretreated animals Likewise, pretreatment with PGE caused a significant increase in glutathione levels in serum as well as in liver in comparison to irradiated controls Conclusion From this study, it is clearly evident that PGE provides protection against radiation-induced hematological and biochemical alterations in Swiss albino mice