University of Rajasthan

About: University of Rajasthan is a education organization based out in Jaipur, India. It is known for research contribution in the topics: Chemical shift & Derivative (chemistry). The organization has 15058 authors who have published 15733 publications receiving 117400 citations. The organization is also known as: Rajasthan University.

A new fractional SIRS-SI malaria disease model with application of vaccines, antimalarial drugs, and spraying

Abstract: The present paper deals with a new fractional SIRS-SI model describing the transmission of malaria disease. The SIRS-SI malaria model is modified by using the Caputo–Fabrizio fractional operator for the inclusion of memory. We also suggest the utilization of vaccines, antimalarial medicines, and spraying for the treatment and control of the malaria disease. The theory of fixed point is utilized to examine the existence of the solution of a fractional SIRS-SI model describing spreading of malaria. The uniqueness of the solution of SIRS-SI model for malaria is also analyzed. It is shown that the treatments have great impact on the dynamical system of human and mosquito populations. The numerical simulation of fractional SIRS-SI malaria model is performed with the aid of HATM and Maple packages to show the effect of different parameters of the treatment of malaria disease. The numerical results for fractional SIRS-SI malaria model reveal that the recommended approach is very accurate and effective.

Centrality dependence of the nuclear modification factor of charged pions, kaons, and protons in Pb-Pb collisions at √sNN=2.76 TeV

Abstract: Transverse momentum (pT) spectra of pions, kaons, and protons up to pT=20GeV/c have been measured in Pb-Pb collisions at √sNN=2.76TeV using the ALICE detector for six different centrality classes covering 0%–80%. The proton-to-pion and the kaon-to-pion ratios both show a distinct peak at pT≈3GeV/c in central Pb-Pb collisions that decreases for more peripheral collisions. For pT>10GeV/c, the nuclear modification factor is found to be the same for all three particle species in each centrality interval within systematic uncertainties of 10%–20%. This suggests there is no direct interplay between the energy loss in the medium and the particle species composition in the hard core of the quenched jet. For pT<10GeV/c, the data provide important constraints for models aimed at describing the transition from soft to hard physics.

Chloroform extract of Carica papaya seeds induces long-term reversible azoospermia in langur monkey

Abstract: Aim To evaluate the antifertility activity of the chloroform extract of Carica papaya seeds by oral administration in langur monkey, Presbytis entellus entellus. Methods The chloroform extract of Carica papaya seeds, 50 mg/kg/day, was administered orally for 360 days to adult male langur monkeys. The sperm characteristics by light and electron microscopy, the sperm functional tests, the semen biochemistry, the serum testosterone level, the Leydig cell function, and the histology and ultrastructure of testis were determined to evaluate the antifertility activity and the blood biochemistry and hematology, to evaluate the toxicology. Results The extract gradually decreased the sperm concentration since days 30-60 of treatment with a total inhibition of sperm motility, a decrease in sperm viability and increase in sperm abnormality. Azoospermia was observed after day 90 of treatment and continued during the whole treatment period. Treatment withdrawal resulted in a gradual recovery in these parameters and 150 days later they reverted to nearly the pretreatment values. Morphological observation of the ejaculated sperm by light and scanning electron microscopy showed deleterious changes, particularly on the mid-piece. Sperm functional tests, viz., sperm mitochondrial activity index, acrosome intactness test and hypo-osmotic swelling test scored in the infertile range during treatment and returned to the fertile values 150 days after drug withdrawal. Histology of the testis revealed shrunken tubules, germ cell atrophy and normal Leydig cells. Ultrastructure of the testis showed vacuolization in the cytoplasm of Sertoli cells and germ cells. Loss of cytoplasmic organelles were evident in the spermatocytes and spermatids. Round spermatids showed loss of Golgi bodies, peripheral mitochondria and vacuolated cytoplasm, indicating maturational arrest. Leydig cell functional test indicated a mild inhibition of steroidogenic function. Haematology and serum biochemistry study disclosed no significant toxicological effect and the serum testosterone level was not affected. Conclusion Carica papaya seed extract may selectively act on the developing germ cells, possibly mediated via Sertoli cells, leading to azoospermia.