Institution
University of Rajshahi
Education•Rajshahi, Bangladesh•
About: University of Rajshahi is a education organization based out in Rajshahi, Bangladesh. It is known for research contribution in the topics: Population & Thin film. The organization has 3803 authors who have published 5051 publications receiving 56573 citations. The organization is also known as: University of Rajshahi & RU.
Papers published on a yearly basis
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Daniel J. Klionsky1, Amal Kamal Abdel-Aziz2, Sara Abdelfatah3, Mahmoud Abdellatif4 +2980 more•Institutions (777)
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
1,129 citations
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TL;DR: In this paper, the authors highlight the recent development of smart drug delivery systems for a number of smart nanocarriers, including liposomes, micelles, dendrimers, meso-porous silica nanoparticles, gold nanoparticles and carbon nanotubes.
576 citations
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TL;DR: It was showed that, Zn was the most and Cd was the least accumulated metal in the studied fish muscles, and there was no possible health risk to consumers due to intake of studied fishes under the current consumption rate.
386 citations
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TL;DR: Maternal anemia remains a significant health problem in low- and middle-income countries and in the South Asian region, South Asian, African, and low- Income countries had a higher pooled anemia prevalence than did other Asian and upper-middle- income countries.
360 citations
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TL;DR: This review is concerned with the lysosomotropic, anti-inflammatory and immunomodulatory mechanisms of chloroquine, hydroxychloroquines, quinacrine and related analogues, and the current evidence for both their beneficial effects and potential adverse manifestations in various diseases.
Abstract: Antimalarial drugs (e.g. chloroquine and its close structural analogues) were developed primarily to treat malaria; however, they are beneficial for many dermatological, immunological, rheumatological and severe infectious diseases, for which they are used mostly today. Chloroquine and hydroxychloroquine, two of the most fascinating drugs developed in the last 50 years, are increasingly recognized for their effectiveness in myriad non-malarial diseases. In advanced research, chloroquine and hydroxychloroquine have been shown to have various immunomodulatory and immunosuppressive effects, and currently have established roles in the management of rheumatic diseases, lupus erythematosus (different forms) and skin diseases, and in the treatment of different forms of cancer. Recently, chloroquine analogues have also been found to have metabolic, cardiovascular, antithrombotic and antineoplastic effects. This review is concerned with the lysosomotropic, anti-inflammatory and immunomodulatory mechanisms of chloroquine, hydroxychloroquine, quinacrine and related analogues, and the current evidence for both their beneficial effects and potential adverse manifestations in various diseases.
343 citations
Authors
Showing all 3875 results
Name | H-index | Papers | Citations |
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Hsisheng Teng | 67 | 213 | 14408 |
Mohammed M. Rahman | 60 | 607 | 15163 |
Shamsuddin Shahid | 49 | 304 | 7860 |
Md. Mizanur Rahman | 44 | 350 | 7123 |
Mohammad Asadullah | 44 | 116 | 5687 |
Ryozo Kuwano | 43 | 171 | 6021 |
Masahiro Sugimoto | 35 | 157 | 5356 |
Prabir Kumar Sarker | 34 | 122 | 5676 |
Kazuaki Sawada | 34 | 461 | 4432 |
Ataur Rahman | 33 | 397 | 5316 |
Fumiyuki Kiuchi | 33 | 204 | 4102 |
Mukhlis A. Rahman | 31 | 235 | 3102 |
Nagib Ahsan | 31 | 77 | 3447 |
Anwarul A. Akhand | 31 | 83 | 2774 |
Shin-ichi Toyabe | 29 | 136 | 3059 |