University of Rennes

About: University of Rennes is a education organization based out in Rennes, France. It is known for research contribution in the topics: Population & Catalysis. The organization has 18404 authors who have published 40374 publications receiving 995327 citations.

Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics.

Abstract: This article represents the first in a series of tutorials on model evaluation in nonlinear mixed effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model Evaluation Group. Numerous tools are available for evaluation of NLMEM, with a particular emphasis on visual assessment. This first basic tutorial focuses on presenting graphical evaluation tools of NLMEM for continuous data. It illustrates graphs for correct or misspecified models, discusses their pros and cons, and recalls the definition of metrics used.

Metabolic and Hormonal Responses to Exercise in Children and Adolescents

Abstract: Ethical and methodological factors limit the availability of data on metabolic and hormonal responses to exercise in children and adolescents. Despite this, it has been reported that young individuals show age-dependent responses to short and long term exercise when compared with adults. Adenosine triphosphate (ATP) and phosphocreatine stores are not age-dependent in children and adolescents. However, phosphorus-31 nuclear magnetic resonance spectroscopy (31PNMR) studies showed smaller reductions in intramuscular pH in children and adolescents during high intensity exercise than adults. Muscle glycogen levels at rest are less important in children, but during adolescence these reach levels observed in adults. Immaturity of anaerobic metabolism in children is a major consideration, and there are several possible reasons for this reduced glycolytic activity. There appear to be higher proportions of slow twitch (type I) fibres in the vastus lateralis part of the quadriceps in children than in untrained adults, and anaerobic glycolytic ATP rephosphorylation may be reduced in young individuals during high intensity exercise. Reduced activity of phosphofructokinase-1 and lactate dehydrogenase enzymes in prepubertal children could also explain the lower glycolytic capacity and the limited production of muscle lactate relative to adults. These observations may be related to reduced sympathetic responses to exhaustive resistance exercise in young people. In contrast, children and adolescents are well adapted to prolonged exercise of moderate intensity. Growth and maturation induce increases in muscle mass, with proliferation of mitochondria and contractile proteins. However, substrate utilisation during exercise differs between children and adults, with metabolic and hormonal adaptations being suggested. Lower respiratory exchange ratio values are often observed in young individuals during prolonged moderate exercise. Data indicate that children rely more on fat oxidation than do adults, and increased free fatty acid mobilisation, glycerol release and growth hormone increases in preadolescent children support this hypothesis. Plasma glucose responses during prolonged exercise are generally comparable in children and adults. When glucose is ingested at the beginning of moderate exercise, plasma glucose levels are higher in children than in adults, but this may be caused by decreased insulin sensitivity during the peripubertal period (as shown by glucose: insulin ratios). Conclusions: Children are better adapted to aerobic exercise because their energy expenditure appears to rely more on oxidative metabolism than is the case in adults. Glycolytic activity is age-dependent, and the relative proportion of fat utilisation during prolonged exercise appears higher in children than in adults.

Coupling groundwater modeling and biological indicators for identifying river/aquifer exchanges

Abstract: Future climate changes and the resulting modifications in anthropogenic activities will alter the interactions between rivers and groundwater. The quantification of these hydraulic interactions is absolutely necessary for achieving sustainable water use and requires accurate analytical methodologies. This report proposes an interdisciplinary approach to the quantitative and qualitative characterization of hydraulic interactions between rivers and shallow aquifers, wherein it outlines the advantages of coupling groundwater modeling with biological markers. As a first step, we built independent diagnostic maps of hydrological exchanges at the sector scale on the basis of hydrogeological modeling and biological indicators. In a second step, these maps were compared to provide a quantitative and qualitative understanding of exchanges between groundwater and surface water. This comparison significantly improved the calibration of groundwater models through a better assessment of boundary zones. Our approach enabled us to identify the conditions under which it could be possible to use biological indicators instead of a large set of piezometric measures. The integration of such combined tools in a future decision support system will assist governmental authorities in proposing appropriate long-term water policies for the preservation of groundwater resources, such as for supplying potable water and/or mitigating pollution risks.

Estimation of helical angles of myosin and collagen by second harmonic generation imaging microscopy.

Abstract: We performed Second Harmonic Generation (SHG) imaging microscopy of endogeneous myosin-rich and collagen-rich tissues in amphibian and mammals. We determined the relative components of the macroscopic susceptibility tensor χ(2) from polarization dependence of SHG intensity. The effective orientation angle θe of the harmonophores has been determined for each protein. For myosin we found θe≈62° and this value was unchanged during myofibrillogenesis. It was also independent of the animal species (xenopus, dog and human). For collagen we found θe≈49° for both type I- and type III- rich tissues. From these results we localized the source of SHG along the single helix of both myosin and collagen.