Institution
University of Rennes
Education•Rennes, France•
About: University of Rennes is a education organization based out in Rennes, France. It is known for research contribution in the topics: Population & Catalysis. The organization has 18404 authors who have published 40374 publications receiving 995327 citations.
Papers published on a yearly basis
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TL;DR: The results show that the three studied factors have a dramatic impact on the final result as strong discrepancies were evidenced depending on the methods used, and suggest that the combination of weighted Minimum Norm Estimator and the Phase Synchronization methods applied on High-Resolution EEG in beta/gamma bands provides the best performance in terms of topological distance.
Abstract: The recent past years have seen a noticeable increase of interest for electroencephalography (EEG) to analyze functional connectivity through brain sources reconstructed from scalp signals. Although considerable advances have been done both on the recording and analysis of EEG signals, a number of methodological questions are still open regarding the optimal way to process the data in order to identify brain networks. In this paper, we analyze the impact of three factors that intervene in this processing: i) the number of scalp electrodes, ii) the combination between the algorithm used to solve the EEG inverse problem and the algorithm used to measure the functional connectivity and iii) the frequency bands retained to estimate the functional connectivity among neocortical sources. Using High-Resolution (hr) EEG recordings in healthy volunteers, we evaluated these factors on evoked responses during picture recognition and naming task. The main reason for selection this task is that a solid literature background is available about involved brain networks (ground truth). From this a priori information, we propose a performance criterion based on the number of connections identified in the regions of interest (ROI) that belong to potentially activated networks. Our results show that the three studied factors have a dramatic impact on the final result (the identified network in the source space) as strong discrepancies were evidenced depending on the methods used. They also suggest that the combination of weighted Minimum Norm Estimator (wMNE) and the Phase Synchronization (PS) methods applied on High-Resolution EEG in beta/gamma bands provides the best performance in term of topological distance between the identified network and the expected network in the above-mentioned cognitive task.
212 citations
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TL;DR: The role of DEPDC5 is extended to focal cortical dysplasias (FCDs) in familial focal epilepsies by extending the role of mTORC1 repressor toDEP domain‐containing protein 5.
Abstract: Objective
The DEPDC5 (DEP domain-containing protein 5) gene, encoding a repressor of the mTORC1 signaling pathway, has recently emerged as a major gene mutated in familial focal epilepsies. We aimed to further extend the role of DEPDC5 to focal cortical dysplasias (FCDs).
Methods
Seven patients from 4 families with DEPDC5 mutations and focal epilepsy associated with FCD were recruited and investigated at the clinical, neuroimaging, and histopathological levels. The DEPDC5 gene was sequenced from genomic blood and brain DNA.
Results
All patients had drug-resistant focal epilepsy, 5 of them underwent surgery, and 1 had a brain biopsy. Electroclinical phenotypes were compatible with FCD II, although magnetic resonance imaging (MRI) was typical in only 4 cases. Histopathology confirmed FCD IIa in 2 patients (including 1 MRI-negative case) and showed FCD I in 2 other patients, and remained inconclusive in the last 2 patients. Three patients were seizure-free postsurgically, and 1 had a worthwhile improvement. Sequencing of blood DNA revealed truncating DEPDC5 mutations in all 4 families; 1 mutation was found to be mosaic in an asymptomatic father. A brain somatic DEPDC5 mutation was identified in 1 patient in addition to the germline mutation.
Interpretation
Germline, germline mosaic, and brain somatic DEPDC5 mutations may cause epilepsy associated with FCD, reinforcing the link between mTORC1 pathway and FCDs. Similarly to other mTORopathies, a “2-hit” mutational model could be responsible for cortical lesions. Our study also indicates that epilepsy surgery is a valuable alternative in the treatment of drug-resistant DEPDC5-positive focal epilepsies, even if the MRI is unremarkable.
212 citations
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TL;DR: Outperforming fluorescein by far, elongated fluorophores give rise to large two-photon absorption cross-sections σ2 in the visible-red or NIR region and high quantum fluorescence yields Φ (see figure; GM = 10-50 cm4 s photon-1 ).
Abstract: Outperforming fluorescein by far, elongated fluorophores (e.g. 1) give rise to large two-photon absorption cross-sections σ2 in the visible-red or NIR region and high quantum fluorescence yields Φ (see figure; GM = 10-50 cm4 s photon-1 ). This opens interesting prospects in the field of two-photon microscopy imaging of cell membranes.
212 citations
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TL;DR: How recent molecular approaches have helped the understanding of the past and recent reticulate history of species is examined, with special focus on allopolyploid speciation.
Abstract: Summary
Hybridization and polyploidy are well illustrated in the genus Spartina. This paper examines how recent molecular approaches have helped our understanding of the past and recent reticulate history of species, with special focus on allopolyploid speciation. Spartina species are tetraploid, hexaploid or dodecaploid perennials, most of them being native to the New World. The molecular phylogeny indicates an ancient split between the tetraploid and the hexaploid species, with S. argentinensis as sister to the hexaploid lineage. Recent hybridization and polyploidization events involved hexaploid species, resulting from introductions of the east-American S. alterniflora. In California, ongoing hybridizations with its sister species S. foliosa result in introgressant hybrid swarms. In Europe, hybridization with S. maritima resulted in S. × neyrautii (France) and S. × townsendii (England), with. S. alterniflora as the maternal parent. The allopolyploid S. anglica resulted from chromosome doubling of S. × townsendii. This young allopolyploid contains divergent homoeologous subgenomes that have not undergone significant changes since their reunion. Hybridization, rather than genome duplication, appears to have shaped the allopolyploid genome at both the structural and epigenetic levels.
212 citations
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TL;DR: The Neuquen Basin this paper was formed as a rift basin in the early Mesozoic and contains some 5000 m of Triassic to Aptian sediment, mainly marine.
211 citations
Authors
Showing all 18470 results
Name | H-index | Papers | Citations |
---|---|---|---|
Philippe Froguel | 166 | 820 | 118816 |
Bart Staels | 152 | 824 | 86638 |
Yi Yang | 143 | 2456 | 92268 |
Geoffrey Burnstock | 141 | 1488 | 99525 |
Shahrokh F. Shariat | 118 | 1637 | 58900 |
Lutz Ackermann | 116 | 669 | 45066 |
Douglas R. MacFarlane | 110 | 864 | 54236 |
Elliott H. Lieb | 107 | 512 | 57920 |
Fu-Yuan Wu | 107 | 367 | 42039 |
Didier Sornette | 104 | 1295 | 44157 |
Stefan Hild | 103 | 452 | 68228 |
Pierre I. Karakiewicz | 101 | 1207 | 40072 |
Philippe Dubois | 101 | 1098 | 48086 |
François Bondu | 100 | 440 | 69284 |
Jean-Michel Savéant | 98 | 517 | 33518 |