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Institution

University of Rennes

EducationRennes, France
About: University of Rennes is a education organization based out in Rennes, France. It is known for research contribution in the topics: Population & Crystal structure. The organization has 18404 authors who have published 40374 publications receiving 995327 citations.


Papers
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Journal ArticleDOI
TL;DR: It is concluded that NFC and HG hydrogels expedite the hepatic differentiation of HepaRG liver progenitor cells better than the standard 2D culture environment as improved cell morphology, expression and localization of hepatic markers, metabolic activity and vectorial transport are shown.

178 citations

Journal ArticleDOI
TL;DR: In this article, the authors considered different sets of observational constraints (Hertzsprung-Russell data, metallicity, various sets of seismic constraints) and determined the age, mass and properties of HD 52265 inferred from stellar models, and quantified the impact of the model input physics and free parameters.
Abstract: Context. In the context of the space missions CoRoT, Kepler, Gaia, TESS, and PLATO, precise and accurate stellar ages, masses, and radii are of paramount importance. For instance, they are crucial for constraining scenarii of planetary formation and evolution. Aims. We aim at quantifying how detailed stellar modelling can improve the accuracy and precision on age and mass of individual stars. To that end, we adopt a multifaceted approach where we carefully examine how the number of observational constraints as well as the uncertainties on observations and on model input physics affect the results of age-dating and weighing. Methods. We modelled in detail the exoplanet host-star HD 52265, a main-sequence, solar-like oscillator that CoRoT observed for four months. We considered different sets of observational constraints (Hertzsprung-Russell data, metallicity, various sets of seismic constraints). For each case, we determined the age, mass, and properties of HD 52265 inferred from stellar models, and we quantified the impact of the model input physics and free parameters. We also compared model ages with ages derived by empirical methods or Hertzsprung-Russell diagram inversion. Results. For our case study HD 52265, our seismic analysis provides an age A = 2.10−2.54 Gyr, a mass M = 1.14−1.32 M� ,a nd a radius R = 1.30−1.34 R� , which corresponds to age, mass, and radius uncertainties of ∼10, ∼7, and ∼1.5 per cent, respectively. These uncertainties account for observational errors and current state-of-the-art stellar model uncertainties. Our seismic study also provides constraints on surface convection properties through the mixing-length, which we find to be 12−15 per cent lower than the solar value. On the other hand, because of helium-mass degeneracy, the initial helium abundance is determined modulo the mass value. Finally, we evaluate the seismic mass of the exoplanet to be Mp sini = 1.17−1.26 MJupiter, much more precise than what can be derived by Hertzsprung-Russell diagram inversion. Conclusions. We demonstrate that asteroseismology allows us to substantially improve the age accuracy that can be achieved with other methods. We emphasize that the knowledge of the mean properties of stellar oscillations – such as the large frequency separation – is not enough to derive accurate ages. We need precise individual frequencies to narrow the age scatter that is a result of the model input physics uncertainties. Further progress is required to better constrain the physics at work in stars and the stars helium content. Our results emphasize the importance of precise classical stellar parameters and oscillation frequencies such as will be obtained by the Gaia and PLATO missions.

178 citations

Journal ArticleDOI
07 May 2012-PLOS ONE
TL;DR: It is demonstrated that natural or synthetic hormones, including androgens or progestagens, and industrial chemicals induce a concentration-dependent GFP expression in radial glial progenitors in zebrafish embryo, identifying this in vivo bioassay as an interesting alternative to detect estrogen mimics in hazard and risk assessment perspective.
Abstract: The tg(cyp19a1b-GFP) transgenic zebrafish expresses GFP (green fluorescent protein) under the control of the cyp19a1b gene, encoding brain aromatase. This gene has two major characteristics: (i) it is only expressed in radial glial progenitors in the brain of fish and (ii) it is exquisitely sensitive to estrogens. Based on these properties, we demonstrate that natural or synthetic hormones (alone or in binary mixture), including androgens or progestagens, and industrial chemicals induce a concentration-dependent GFP expression in radial glial progenitors. As GFP expression can be quantified by in vivo imaging, this model presents a very powerful tool to screen and characterize compounds potentially acting as estrogen mimics either directly or after metabolization by the zebrafish embryo. This study also shows that radial glial cells that act as stem cells are direct targets for a large panel of endocrine disruptors, calling for more attention regarding the impact of environmental estrogens and/or certain pharmaceuticals on brain development. Altogether these data identify this in vivo bioassay as an interesting alternative to detect estrogen mimics in hazard and risk assessment perspective.

178 citations

Journal ArticleDOI
21 Aug 2020-Science
TL;DR: In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP–cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy.
Abstract: Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2Kb-restricted CD8+ T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP-cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy. In melanoma patients, T cell clones recognizing naturally processed cancer antigens that are cross-reactive with microbial peptides were detected.

177 citations

Journal ArticleDOI
TL;DR: The robust cost functions and the associated hierarchical minimization techniques that are proposed mix efficiently non-parametric (dense) representations, local interacting parametric representations, and global non-interacting parametric representation related to a partition into regions.
Abstract: In this paper we present a comprehensive energy-based framework for the estimation and the segmentation of the apparent motion in image sequences. The robust cost functions and the associated hierarchical minimization techniques that we propose mix efficiently non-parametric (dense) representations, local interacting parametric representations, and global non-interacting parametric representations related to a partition into regions. Experimental comparisons, both on synthetic and real images, demonstrate the merit of the approach on different types of photometric and kinematic contents ranging from moving rigid objects to moving fluids.

177 citations


Authors

Showing all 18470 results

NameH-indexPapersCitations
Philippe Froguel166820118816
Bart Staels15282486638
Yi Yang143245692268
Geoffrey Burnstock141148899525
Shahrokh F. Shariat118163758900
Lutz Ackermann11666945066
Douglas R. MacFarlane11086454236
Elliott H. Lieb10751257920
Fu-Yuan Wu10736742039
Didier Sornette104129544157
Stefan Hild10345268228
Pierre I. Karakiewicz101120740072
Philippe Dubois101109848086
François Bondu10044069284
Jean-Michel Savéant9851733518
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202321
2022176
20212,655
20202,735
20192,670
20182,378