University of Rennes

About: University of Rennes is a education organization based out in Rennes, France. It is known for research contribution in the topics: Population & Crystal structure. The organization has 18404 authors who have published 40374 publications receiving 995327 citations.

Structurally Precise Dichalcogenolate-Protected Copper and Silver Superatomic Nanoclusters and Their Alloys

Abstract: ConspectusThe chalcogenolato silver and copper superatoms are currently a topic of cutting edge research besides the extensively studied Aun(SR)m clusters. Crystal structure analysis is an indispen...

Role of endoplasmic reticulum stress in drug‐induced toxicity

Abstract: Drug-induced toxicity is a key issue for public health because some side effects can be severe and life-threatening. These adverse effects can also be a major concern for the pharmaceutical companies since significant toxicity can lead to the interruption of clinical trials, or the withdrawal of the incriminated drugs from the market. Recent studies suggested that endoplasmic reticulum (ER) stress could be an important event involved in drug liability, in addition to other key mechanisms such as mitochondrial dysfunction and oxidative stress. Indeed, drug-induced ER stress could lead to several deleterious effects within cells and tissues including accumulation of lipids, cell death, cytolysis, and inflammation. After recalling important information regarding drug-induced adverse reactions and ER stress in diverse pathophysiological situations, this review summarizes the main data pertaining to drug-induced ER stress and its potential involvement in different adverse effects. Drugs presented in this review are for instance acetaminophen (APAP), arsenic trioxide and other anticancer drugs, diclofenac, and different antiretroviral compounds. We also included data on tunicamycin (an antibiotic not used in human medicine because of its toxicity) and thapsigargin (a toxic compound of the Mediterranean plant Thapsia garganica) since both molecules are commonly used as prototypical toxins to induce ER stress in cellular and animal models.

Spartina anglica C. E. Hubbard: a natural model system for analysing early evolutionary changes that affect allopolyploid genomes.

Abstract: Spartina anglica arose during the end of the 19th century in England by hybridization between the indigenous Spartina maritima and the introduced East American Spartina alterniflora and following genome duplication of the hybrid (S. x townsendii). This system allows investigations of the early evolutionary changes that accompany stabilization of a new allopolyploid species in natural populations. Various molecular data indicate that S. anglica has resulted from a unique parental genotype. This young species contains two distinctly divergent homoeologous genomes that have not undergone extensive change since their reunion. No burst of retroelements has been encountered in the F 1 hybrid or in the allopolyploid, suggesting a 'structural genomic stasis' rather than 'rapid genomic changes'. However, modifications of the methylation patterns in the genomes of S. x townsendii and S. anglica indicate that in this system, epigenetic changes have followed both hybridization and polyploidization.

Superstable granular heap in a thin channel.

Abstract: We observed experimentally a new regime for granular flows in an inclined channel with a flow-rate-controlled system. For high flow rates, the flow occurs atop a static granular heap whose angle is considerably higher than those usually exhibited by granular heaps. The properties of such superstable heaps (SSH) are drastically affected by a change in the channel width W. This indicates that the unusual stability of these heaps can be accounted for by the flowing layer and its friction on the sidewalls. A simple depth-averaged model, assuming Coulomb friction, shows that the SSH angle scales as h/W (W being the channel width), and that grain size plays no part.