Institution
University of Rennes
Education•Rennes, France•
About: University of Rennes is a education organization based out in Rennes, France. It is known for research contribution in the topics: Population & Crystal structure. The organization has 18404 authors who have published 40374 publications receiving 995327 citations.
Topics: Population, Crystal structure, Ruthenium, Catalysis, Antenna (radio)
Papers published on a yearly basis
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TL;DR: In this paper, the authors present evidence concerning the style of deformation contemporaneous with the high-pressure metamorphism in the Ile de Groix (South Brittany, France).
Abstract: THE Ile de Groix (South Brittany, France) is made up of a series of metapelitic rocks intercalated with metabasic horizons, most of which contain glaucophane1,2. Palaeozoic metamorphism2–4 in the basic rocks produced various assemblages, such as glaucophane + lawsonite5,6 or omphacite + garnet, characteristic of high pressure and low2 to medium1 temperatures. All these rocks were later slightly or completely recrystallised under greenschist facies conditions1,5,6. The presence of a contrasting metamorphic facies (high temperature/low to medium pressure), on the mainland north of Groix, has led several workers to propose the existence of a paired metamorphic belt2 of pre-Hercynian age4,7,8, formed as a result of subduction2,7–9. We present evidence here concerning the style of deformation contemporaneous with the high-pressure metamorphism.
166 citations
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TL;DR: The "Stack & Draw" procedure is demonstrated to be a powerful tool against crystallisation when used with a very stable chalcogenide glass, and the mode field diameter of the fundamental mode is measured and compared with calculations using the multipole method.
Abstract: We report recent progress on fabrication of solid core microstructured fibers in chalcogenide glass. Several complex and regular holey fibers from Ga5Ge20Sb10S65 chalcogenide glass have been realized. We demonstrate that the “Stack & Draw“ procedure is a powerful tool against crystallisation when used with a very stable chalcogenide glass. For a 3 ring multimode Holey Fiber, we measure the mode field diameter of the fundamental mode and compare it successfully with calculations using the multipole method. We also investigate, via numerical simulations, the behaviour of fundamental mode guiding losses of microstructured fibers as a function of the matrix refractive index, and quantify the advantage obtained by using a high refractive index glass such as chalcogenide instead of low index glass.
166 citations
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TL;DR: The results bring the first demonstration of long-term stable expression of liver-specific markers in HepaRG hepatocyte cultures maintained at confluence and show that these cells represent a suitable in vitro liver cell model for analysis of acute and chronic toxicity as well as genotoxicity of chemicals in human liver.
Abstract: The human hepatoma HepaRG cells are able to differentiate in vitro into hepatocyte-like cells and to express various liver-specific functions, including the major cytochromes P450. This study was aimed to determine whether differentiated HepaRG cells retained their specific functional capacities for a long time period at confluence. We show that expression of transcripts encoding CYP1A2, 2B6, 3A4, and 2E1, several phase II and antioxidant enzymes, membrane transporters, including organic cation transporter 1 and bile salt export pump, the nuclear receptors constitutive androstane receptor and pregnane X receptor, and aldolase B remained relatively stable for at least the 4-week confluence period tested. Similarly, activities of CYP3A4 and CYP1A2 and their responsiveness to prototypical inducers were well preserved. Aflatoxin B 1 , a potent hepatotoxicant and carcinogen, induced a dose-dependent and cumulative cytotoxicity. Furthermore, at a concentration as low as 0.1 μM, this mycotoxin caused a decrease in both CYP3A4 activity and intracellular ATP associated with morphological alterations, after 14 days following every 2-day exposure. Moreover, using the comet assay, a dose-dependent DNA damage was observed after a 3-h treatment of differentiated HepaRG cells with 1 to 5 μM aflatoxin B 1 in the absence of any cell damage, and this DNA damaging effect was strongly reduced in the presence of ketoconazole, a CYP3A4 inhibitor. These results bring the first demonstration of long-term stable expression of liver-specific markers in HepaRG hepatocyte cultures maintained at confluence and show that these cells represent a suitable in vitro liver cell model for analysis of acute and chronic toxicity as well as genotoxicity of chemicals in human liver.
166 citations
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Yale University1, University of Rennes2, University of Copenhagen3, University of Vermont4, VU University Amsterdam5, ETH Zurich6, University of Manchester7, University of Montpellier8, Swedish University of Agricultural Sciences9, Nanyang Technological University10, National Center for Atmospheric Research11, The Nature Conservancy12, Wageningen University and Research Centre13
TL;DR: It is found that contrary to predictions from the hierarchical model, decomposer (microbial) biomass strongly regulates decomposition at regional scales, and the size of the microbial biomass dictates the absolute change in decomposition rates with changing climate variables.
Abstract: Our basic understanding of plant litter decomposition informs the assumptions underlying widely applied soil biogeochemical models, including those embedded in Earth system models. Confidence in projected carbon cycle-climate feedbacks therefore depends on accurate knowledge about the controls regulating the rate at which plant biomass is decomposed into products such as CO2. Here we test underlying assumptions of the dominant conceptual model of litter decomposition. The model posits that a primary control on the rate of decomposition at regional to global scales is climate (temperature and moisture), with the controlling effects of decomposers negligible at such broad spatial scales. Using a regional-scale litter decomposition experiment at six sites spanning from northern Sweden to southern France-and capturing both within and among site variation in putative controls-we find that contrary to predictions from the hierarchical model, decomposer (microbial) biomass strongly regulates decomposition at regional scales. Furthermore, the size of the microbial biomass dictates the absolute change in decomposition rates with changing climate variables. Our findings suggest the need for revision of the hierarchical model, with decomposers acting as both local- and broad-scale controls on litter decomposition rates, necessitating their explicit consideration in global biogeochemical models.
166 citations
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TL;DR: In this paper, the structure and history of salt diapirs in large ancient evaporitic basins such as the southeastern North Sea basin suggests that diapirism is controlled by crustal-scale extension.
166 citations
Authors
Showing all 18470 results
Name | H-index | Papers | Citations |
---|---|---|---|
Philippe Froguel | 166 | 820 | 118816 |
Bart Staels | 152 | 824 | 86638 |
Yi Yang | 143 | 2456 | 92268 |
Geoffrey Burnstock | 141 | 1488 | 99525 |
Shahrokh F. Shariat | 118 | 1637 | 58900 |
Lutz Ackermann | 116 | 669 | 45066 |
Douglas R. MacFarlane | 110 | 864 | 54236 |
Elliott H. Lieb | 107 | 512 | 57920 |
Fu-Yuan Wu | 107 | 367 | 42039 |
Didier Sornette | 104 | 1295 | 44157 |
Stefan Hild | 103 | 452 | 68228 |
Pierre I. Karakiewicz | 101 | 1207 | 40072 |
Philippe Dubois | 101 | 1098 | 48086 |
François Bondu | 100 | 440 | 69284 |
Jean-Michel Savéant | 98 | 517 | 33518 |