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Institution

University of Rennes

EducationRennes, France
About: University of Rennes is a education organization based out in Rennes, France. It is known for research contribution in the topics: Population & Crystal structure. The organization has 18404 authors who have published 40374 publications receiving 995327 citations.


Papers
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Journal ArticleDOI
TL;DR: Combination therapy, duration of seton drainage less than 34 weeks, and long-term treatment with infliximab were associated with better outcomes, and about two-thirds of patients with fistulizing perianal Crohn's disease had fistula closure, and one-third had fistulas recurrence after inflixIMab initiation.

162 citations

Journal ArticleDOI
TL;DR: The authors' results unambiguously show how initially localized chemical changes can propagate at the level of the global protein conformation in the picosecond timescale.
Abstract: Light absorption can trigger biologically relevant protein conformational changes The light-induced structural rearrangement at the level of a photoexcited chromophore is known to occur in the femtosecond timescale and is expected to propagate through the protein as a quake-like intramolecular motion Here we report direct experimental evidence of such 'proteinquake' observed in myoglobin through femtosecond X-ray solution scattering measurements performed at the Linac Coherent Light Source X-ray free-electron laser An ultrafast increase of myoglobin radius of gyration occurs within 1 picosecond and is followed by a delayed protein expansion As the system approaches equilibrium it undergoes damped oscillations with a ~36-picosecond time period Our results unambiguously show how initially localized chemical changes can propagate at the level of the global protein conformation in the picosecond timescale

162 citations

Journal ArticleDOI
TL;DR: In this paper, a mesoscale erosion/deposition model is presented, which couples the dynamics of streamflow and topography through a sediment transport length function x(q), which is the average travel distance of a particle in the flow before being trapped on topography.
Abstract: We present a mesoscale erosion/deposition model, which differs from previous landscape evolution models equations by taking explicitly into account a mass balance equation for the streamflow. The geological and hydrological complexity is lumped into two basic fluxes (erosion and deposition) and two averaged parameters (unit width discharge q and stream slope s). The model couples the dynamics of streamflow and topography through a sediment transport length function x(q), which is the average travel distance of a particle in the flow before being trapped on topography. This property reflects a time lag between erosion and deposition, which allows the streamflow not to be instantaneously at capacity. The so-called x-q model may reduce either to transport-limited or to detachment-limited erosion modes depending on x. But it also may not. We show in particular how it does or does not for steady state topographies, long-term evolution, and high-frequency base level perturbations. Apart from the unit width discharge and the settling velocity, the x(q) function depends on a dimensionless number encompassing the way sediment is transported within the streamflow. Using models of concentration profile through the water column, we show the dependency of this dimensionless coefficient on the Rouse number. We discuss how consistent the x-q model framework is with bed load scaling expressions and Einstein's conception of sediment motion.

162 citations

Journal ArticleDOI
TL;DR: Cryo-EM structures of human SBDS and SBDS–EFL1 bound to Dictyostelium discoideum 60S ribosomal subunits with and without endogenous eIF 6 reveal the conserved mechanism of eIF6 release, which is corrupted in both inherited and sporadic leukemias.
Abstract: SBDS protein (deficient in the inherited leukemia-predisposition disorder Shwachman-Diamond syndrome) and the GTPase EFL1 (an EF-G homolog) activate nascent 60S ribosomal subunits for translation by catalyzing eviction of the antiassociation factor eIF6 from nascent 60S ribosomal subunits. However, the mechanism is completely unknown. Here, we present cryo-EM structures of human SBDS and SBDS-EFL1 bound to Dictyostelium discoideum 60S ribosomal subunits with and without endogenous eIF6. SBDS assesses the integrity of the peptidyl (P) site, bridging uL16 (mutated in T-cell acute lymphoblastic leukemia) with uL11 at the P-stalk base and the sarcin-ricin loop. Upon EFL1 binding, SBDS is repositioned around helix 69, thus facilitating a conformational switch in EFL1 that displaces eIF6 by competing for an overlapping binding site on the 60S ribosomal subunit. Our data reveal the conserved mechanism of eIF6 release, which is corrupted in both inherited and sporadic leukemias.

162 citations

Journal ArticleDOI
TL;DR: The chemistry and physics of molecule-based materials are exciting subjects, and due to potential applications this area is being extensively investigated as mentioned in this paper, and considerable effort is currently being made to design and to investigate new materials involving interplay or synergy between multiple physical properties.
Abstract: The chemistry and physics of molecule-based materials are exciting subjects, and due to potential applications this area is being extensively investigated. Considerable effort is currently being made to design and to investigate new materials involving interplay or synergy between multiple physical properties. This microreview examines materials combining magnetism and electrical properties. Some fundamental background material is covered, together with a discussion of constraints on the design of molecular materials with these physical properties. Some examples from the literature are then related, in order to illustrate the achievements in this area. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

161 citations


Authors

Showing all 18470 results

NameH-indexPapersCitations
Philippe Froguel166820118816
Bart Staels15282486638
Yi Yang143245692268
Geoffrey Burnstock141148899525
Shahrokh F. Shariat118163758900
Lutz Ackermann11666945066
Douglas R. MacFarlane11086454236
Elliott H. Lieb10751257920
Fu-Yuan Wu10736742039
Didier Sornette104129544157
Stefan Hild10345268228
Pierre I. Karakiewicz101120740072
Philippe Dubois101109848086
François Bondu10044069284
Jean-Michel Savéant9851733518
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202321
2022176
20212,655
20202,735
20192,670
20182,378