Showing papers by "University of Rhode Island published in 2011"

Stages of change

Abstract: The transtheoretical model, in general, and the stages of change, in particular, have proven useful in adapting or tailoring treatment to the individual. We define the stages and processes of change and then review previous meta-analyses on their interrelationship. We report an original meta-analysis of 39 studies, encompassing 8,238 psychotherapy patients, to assess the ability of stages of change and related readiness measures to predict psychotherapy outcomes. Clinically significant effect sizes were found for the association between stage of change and psychotherapy outcomes (d = .46); the amount of progress clients make during treatment tends to be a function of their pretreatment stage of change. We examine potential moderators in effect size by study outcome, patient characteristics, treatment features, and diagnosis. We also review the large volume of behavioral health research, but scant psychotherapy research, that demonstrates the efficacy of matching treatment to the patient's stage of change. Limitations of the extant research are noted, and practice recommendations are advanced.

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants.

Abstract: Vascular plants appeared ~410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes.

Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms

Abstract: Dengue is a mosquito-borne viral disease of expanding geographical range and incidence. The existence of four viral serotypes and the association of prior dengue virus infection with an increased risk for more severe disease have presented significant obstacles to vaccine development. An increased understanding of the adaptive immune response to natural dengue virus infection and candidate dengue vaccines has helped to define the specific antibody and T cell responses that are associated with either protective or pathological immunity during dengue infection. Further characterization of immunological correlates of disease outcome and the validation of these findings in vaccine trials will be invaluable for developing effective dengue vaccines.

Continuous Locomotion-Mode Identification for Prosthetic Legs Based on Neuromuscular–Mechanical Fusion

Abstract: In this study, we developed an algorithm based on neuromuscular-mechanical fusion to continuously recognize a variety of locomotion modes performed by patients with transfemoral (TF) amputations. Electromyographic (EMG) signals recorded from gluteal and residual thigh muscles and ground reaction forces/moments measured from the prosthetic pylon were used as inputs to a phase-dependent pattern classifier for continuous locomotion-mode identification. The algorithm was evaluated using data collected from five patients with TF amputations. The results showed that neuromuscular-mechanical fusion outperformed methods that used only EMG signals or mechanical information. For continuous performance of one walking mode (i.e., static state), the interface based on neuromuscular-mechanical fusion and a support vector machine (SVM) algorithm produced 99% or higher accuracy in the stance phase and 95% accuracy in the swing phase for locomotion-mode recognition. During mode transitions, the fusion-based SVM method correctly recognized all transitions with a sufficient predication time. These promising results demonstrate the potential of the continuous locomotion-mode classifier based on neuromuscular-mechanical fusion for neural control of prosthetic legs.

A Thermodynamic Approach for Assessing the Environmental Exposure of Chemicals Absorbed to Microplastic

Abstract: The environmental distribution and fate of microplastic in the marine environment represents a potential cause of concern. One aspect is the influence that microplastic may have on enhancing the transport and bioavailability of persistent, bioaccumulative, and toxic substances (PBT). In this study we assess these potential risks using a thermodynamic approach, aiming to prioritize the physicochemical properties of chemicals that are most likely absorbed by microplastic and therefore ingested by biota. Using a multimedia modeling approach, we define a chemical space aimed at improving our understanding of how chemicals partition in the marine environment with varying volume ratios of air/water/organic carbon/polyethylene, where polyethylene represents a main group of microplastic. Results suggest that chemicals with log KOW > 5 have the potential to partition >1% to polyethylene. Food-web model results suggest that reductions in body burden concentrations for nonpolar organic chemicals are likely to occur ...

Critical oxygen levels and metabolic suppression in oceanic oxygen minimum zones

Abstract: Summary The survival of oceanic organisms in oxygen minimum zones (OMZs) depends on their total oxygen demand and the capacities for oxygen extraction and transport, anaerobic ATP production and metabolic suppression. Anaerobic metabolism and metabolic suppression are required for daytime forays into the most extreme OMZs. Critical oxygen partial pressures are, within a range, evolved to match the minimum oxygen level to which a species is exposed. This fact demands that low oxygen habitats be defined by the biological response to low oxygen rather than by some arbitrary oxygen concentration. A broad comparative analysis of oxygen tolerance facilitates the identification of two oxygen thresholds that may prove useful for policy makers as OMZs expand due to climate change. Between these thresholds, specific physiological adaptations to low oxygen are required of virtually all species. The lower threshold represents a limit to evolved oxygen extraction capacity. Climate change that pushes oxygen concentrations below the lower threshold (∼0.8 kPa) will certainly result in a transition from an ecosystem dominated by a diverse midwater fauna to one dominated by diel migrant biota that must return to surface waters at night. Animal physiology and, in particular, the response of animals to expanding hypoxia, is a critical, but understudied, component of biogeochemical cycles and oceanic ecology. Here, I discuss the definition of hypoxia and critical oxygen levels, review adaptations of animals to OMZs and discuss the capacity for, and prevalence of, metabolic suppression as a response to temporary residence in OMZs and the possible consequences of climate change on OMZ ecology.

Predicting Reading Comprehension on the Internet Contributions of Offline Reading Skills, Online Reading Skills, and Prior Knowledge

Abstract: This study investigated the extent to which new reading comprehension proficiencies may be required when adolescents read for information on the Internet. Seventh graders (N = 109) selected from a ...

Metal-free intermolecular oxidative C-N bond formation via tandem C-H and N-H bond functionalization.

Abstract: The development of a novel intermolecular oxidative amination reaction, a synthetic transformation that involves the simultaneous functionalization of both a N–H and C–H bond, is described. The process, which is mediated by an I(III) oxidant and contains no metal catalysts, provides a rapid and green method for synthesizing protected anilines from simple arenes and phthalimide. Mechanistic investigations indicate that the reaction proceeds via nucleophilic attack of the phthalimide on an aromatic radical cation, as opposed to the electrophilic aromatic amination that has been reported for other I(III) amination reactions. The application of this new reaction to the synthesis of a variety of substituted aniline derivatives is demonstrated.

Antecedents and Consequences of Risky Credit Behavior Among College Students: Application and Extension of the Theory of Planned Behavior

Abstract: The Credit Card Act of 2009 reflects increased public policy concern about the risky credit behaviors of young adults. This act promotes increased responsibility of parents and implies that young adults must acquire financial knowledge and practice responsible financial behaviors. This study addresses this public issue by investigating the psychological processes underlying young adults' risky credit card behaviors and the role of parents and financial knowledge in the financial behavior of young adults. A conceptual model based on an extension of the theory of planned behavior is proposed. The authors collected data from a sample of first-year students at a major public university. The results show that both parental norm and parental socioeconomic status are important factors that influence students' risky credit behaviors. Furthermore, subjective financial knowledge does more to prevent risky credit behaviors than objective financial knowledge. Finally, behavioral intention is the most importa...

The mediating role of organizational job embeddedness in the LMX-outcomes relationships

Abstract: This study furthers the research on leader–member exchange (LMX) and organizational job embeddedness by examining the relationships between these variables and three workplace outcomes. In particular, we employ the Conservation of Resources theory to hypothesize LMX as a predictor of organizational job embeddedness, and organizational job embeddedness to be a predictor of the outcomes of job satisfaction, turnover intentions, and actual turnover. Further, we suggest organizational job embeddedness is an intermediary mechanism that mediates the LMX–outcome relationships. We examine these proposed relationships in a sample of 205 automobile employees. In general, our results provide strong support for the proposed associations. Contributions, limitations, practical implications, and directions for future research are offered.

The Financial Management Behavior Scale: Development and Validation

Abstract: Although research on financial management behavior is common, few financial management behavior scales exist that are simultaneously multi-dimensional, psychometrically validated, and validated using nationally representative data. Using data from a nationally representative sample of adults, this study developed and examined the psychometric properties of a new scale of financial management behaviors. The Financial Management Behavior Scale (FMBS) displayed adequate reliability (alpha = .81). The FMBS was highly associated with other measures of financial management behaviors and was predictive of participants’ actual levels of savings and consumer debt. These findings suggest that the full FMBS is a reliable and valid measure of financial management behaviors, though the subscales need refinement.

Creating a buzz about insect genomes.

Abstract: WHEN E. O. WILSON PROCLAIMED THAT INSECTS ARE THE “little creatures who run the world” (1), he was simply reaffi rming the long-recognized dominance of the largest class of animals on our planet. Insects constitute approximately 53% of all living species, with one group alone (the ants), accounting for almost a quarter of terrestrial animal biomass (2). These tiny creatures also exert outsized impacts on human affairs. By serving as pollinators to more than 75% of fl owering plant species (3), insects are essential to the maintenance and productivity of natural and agricultural ecosystems. But other insects consume or damage more than 25% of all agricultural, forestry, and livestock production in the United States, costing our economy more than $30 billion annually (4). These losses occur despite more than 150 years of concerted efforts to prevent them. Insects and other arthropods not only affect our food supply, they also carry disease. Parasites and pathogens carried by insects and their relatives have led to more loss of human life than all wars in recorded history; even today, insect-borne diseases are a leading cause of death of children under the age of 5 (5). The annual cost of vector-borne diseases worldwide is estimated at almost $50 billion (6). Clearly, our health and well-being depend on our ability to understand and manage arthropods of agricultural, medical, and veterinary importance. In the past decade, biomedical research has increasingly relied on information obtained from sequencing the human genome, and early genome-enabled successes have inspired a new vision of genomic medicine (7). We believe that genomics also can improve our lives by contributing to a better understanding of insect biology and transforming our ability to manage arthropods that threaten our health, food supply, and economic security. Because of the overwhelming diversity and abundance of insects, achieving these goals will require a project of grand scale. Therefore, we, the undersigned, are pleased to announce the launch of the “i5k” initiative to sequence the genomes of 5000 species of insects and other arthropods during the next 5 years (8). This project is aimed at sequencing and analyzing the genomes of all species known to be important to worldwide agriculture and food safety, medicine, and energy production; all species used as models in biology; the most abundant insects in world ecosystems; and, to achieve a deep understanding of arthropod evolution, representatives of insect relatives in every major branch of arthropod phylogeny. The i5k initiative will be broad and inclusive, seeking to involve scientists from around the world and obtain funding from academia, governments, industry, and private sources. We also aim to encourage new collaborative research by computer scientists, bioinformaticians, and biologists to overcome the challenges of handling this unprecedented volume of data and derive meaning from these genomes. GENE E. ROBINSON,* KEVIN J. HACKETT, MARY PURCELL-MIRAMONTES, SUSAN J. BROWN, JAY D. EVANS, MARIAN R. GOLDSMITH, DANIEL LAWSON, JACK OKAMURO, HUGH M. ROBERTSON, DAVID J. SCHNEIDER Department of Entomology, University of Illinois at UrbanaChampaign, Urbana, IL 61801, USA. USDA Agricultural Research Service, Beltsville, MD 20705, USA. USDA National Institute of Food and Agriculture, Washington, DC 20250, USA. Division of Biology, Kansas State University, Manhattan, KS 66506–4190, USA. Arthropod Genomics Consortium and European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. College of the Environment and Life Sciences, University of Rhode Island, Kingston, RI 02881, USA. USDA Agricultural Research Service, Ithaca, NY 14853, USA.

Effects of Photoacoustic Imaging and Photothermal Ablation Therapy Mediated by Targeted Hollow Gold Nanospheres in an Orthotopic Mouse Xenograft Model of Glioma

Abstract: Advancements in nanotechnology have made it possible to create multifunctional nanostructures that can be used simultaneously to image and treat cancers For example, hollow gold nanospheres (HAuNS) have been shown to generate intense photoacoustic signals and induce efficient photothermal ablation (PTA) therapy In this study, we used photoacoustic tomography, a hybrid imaging modality, to assess the intravenous delivery of HAuNS targeted to integrins that are overexpressed in both glioma and angiogenic blood vessels in a mouse model of glioma Mice were then treated with near-infrared laser, which elevated tumor temperature by 207°C We found that PTA treatment significantly prolonged the survival of tumor-bearing mice Taken together, these results show the feasibility of using a single nanostructure for image-guided local tumor PTA therapy with photoacoustic molecular imaging

I-CASH: Intelligently Coupled Array of SSD and HDD

Abstract: This paper presents a new disk I/O architecture composed of an array of a flash memory SSD (solid state disk) and a hard disk drive (HDD) that are intelligently coupled by a special algorithm. We call this architecture I-CASH: Intelligently Coupled Array of SSD and HDD. The SSD stores seldom-changed and mostly read reference data blocks whereas the HDD stores a log of deltas between currently accessed I/O blocks and their corresponding reference blocks in the SSD so that random writes are not performed in SSD during online I/O operations. High speed delta compression and similarity detection algorithms are developed to control the pair of SSD and HDD. The idea is to exploit the fast read performance of SSDs and the high speed computation of modern multi-core CPUs to replace and substitute, to a great extent, the mechanical operations of HDDs. At the same time, we avoid runtime SSD writes that are slow and wearing. An experimental prototype I-CASH has been implemented and is used to evaluate I-CASH performance as compared to existing SSD/HDD I/O architectures. Numerical results on standard benchmarks show that I-CASH reduces the average I/O response time by an order of magnitude compared to existing disk I/O architectures such as RAID and SSD/HDD storage hierarchy, and provides up to 2.8 speedup over state-of-the-art pure SSD storage. Furthermore, I-CASH reduces random writes to SSD implying reduced wearing and prolonged life time of the SSD.

Geotechnical aspects of the 22 february 2011 christchurch earthquake

Abstract: SUMMARY The 22 February 2011, Mw6.2-6.3 Christchurch earthquake is the most costly earthquake to affect New Zealand, causing 181 fatalities and severely damaging thousands of residential and commercial buildings, and most of the city lifelines and infrastructure. This manuscript presents an overview of observed geotechnical aspects of this earthquake as well as some of the completed and on-going research investigations. A unique aspect, which is particularly emphasized, is the severity and spatial extent of liquefaction occurring in native soils. Overall, both the spatial extent and severity of liquefaction in the city was greater than in the preceding 4 th September 2010 Darfield earthquake, including numerous areas that liquefied in both events. Liquefaction and lateral spreading, variable over both large and short spatial scales, affected commercial structures in the Central Business District (CBD) in a variety of ways including: total and differential settlements and tilting; punching settlements of structures with shallow foundations; differential movements of components of complex structures; and interaction of adjacent structures via common foundation soils. Liquefaction was most severe in residential areas located to the east of the CBD as a result of stronger ground shaking due to the proximity to the causative fault, a high water table approximately 1m from the surface, and soils with composition and states of high susceptibility and potential for liquefaction. Total and differential settlements, and lateral movements, due to liquefaction and lateral spreading is estimated to have severely compromised 15,000 residential structures, the majority of which otherwise sustained only minor to moderate damage directly due to inertial loading from ground shaking. Liquefaction also had a profound effect on lifelines and other infrastructure, particularly bridge structures, and underground services. Minor damage was also observed at flood stop banks to the north of the city, which were more severely impacted in the 4 th September 2010 Darfield earthquake. Due to the large high-frequency ground motion in the Port hills numerous rock falls and landslides also occurred, resulting in several fatalities and rendering some residential areas uninhabitable.

Sexual media use and relational satisfaction in heterosexual couples

Abstract: This study assessed how sexual media use by one or both members of a romantic dyad relates to relationship and sexual satisfaction. A total of 217 heterosexual couples completed an Internet survey that assessed sexual media use, relationship and sexual satisfaction, and demographic variables. Results revealed that a higher frequency of men’s sexual media use related to negative satisfaction in men, while a higher frequency of women’s sexual media use related to positive satisfaction in male partners. Reasons for sexual media use differed by gender: Men reported primarily using sexual media for masturbation, while women reported primarily using sexual media as part of lovemaking with their partners. Shared sexual media use was associated with higher relational satisfaction compared to solitary sexual media use.

Incremental Learning From Stream Data

Abstract: Recent years have witnessed an incredibly increasing interest in the topic of incremental learning Unlike conventional machine learning situations, data flow targeted by incremental learning becomes available continuously over time Accordingly, it is desirable to be able to abandon the traditional assumption of the availability of representative training data during the training period to develop decision boundaries Under scenarios of continuous data flow, the challenge is how to transform the vast amount of stream raw data into information and knowledge representation, and accumulate experience over time to support future decision-making process In this paper, we propose a general adaptive incremental learning framework named ADAIN that is capable of learning from continuous raw data, accumulating experience over time, and using such knowledge to improve future learning and prediction performance Detailed system level architecture and design strategies are presented in this paper Simulation results over several real-world data sets are used to validate the effectiveness of this method

High-precision U-Pb zircon geochronology of the Late Triassic Chinle Formation, Petrified Forest National Park (Arizona, USA): Temporal constraints on the early evolution of dinosaurs

Abstract: The Triassic successions of the Colorado Plateau preserve an important record of vertebrate evolution and climate change, but correlations to a global Triassic framework are hampered by a lack of geochronological control. Tuffaceous sandstones and siltstones were collected from the Upper Triassic Chinle Formation exposed in the Petrified Forest National Park, Arizona, USA, within a refined stratigraphic context of 31 detailed measured sections. U-Pb analyses by the isotope dilution–thermal ionization mass spectrometry (ID-TIMS) method constrain maximum depositional ages for nine tuffaceous beds and provide new insights into the depositional history of the Chinle fluvial system. The base of the Blue Mesa Member of the Chinle Formation is placed at ca. 225 Ma, and the top of the Petrified Forest Member is placed at 208 Ma or younger, bracketing an ∼280-m-thick section that spans nearly the entire Norian Stage of the Late Triassic. Estimated sediment accumulation rates throughout the section reflect extensive hiatuses and/or sediment removal by channel erosion. The new geochronology for the Chinle Formation underscores the potential pitfalls of correlation of fluvial units based solely on lithostratigraphic criteria. A mid-Norian age (ca. 219–213 Ma) for the distinctive Sonsela conglomeratic sandstone bed constrains the Adamanian-Revueltian land vertebrate faunachron boundary. Our new data permit a significant time overlap between the lower Chinle sequence and the dinosauromorph-rich Ischigualasto Formation of northwestern Argentina. Near-contemporaneity of the trans-American deposits and their faunal similarities imply that early dinosaur evolution occurred rapidly across the Americas.

Cell-penetrating homochiral cyclic peptides as nuclear-targeting molecular transporters.

Abstract: The intracellular delivery of biologically active cargos by employing linear cell-penetrating peptides (CPPs) has been previously reported. Conjugation to linear cationic CPPs, such as TAT (trans-acting activator of transcription; a peptide derived from the HIV-1 transactivator protein), 3] penetratin, antennapedia, or oligoarginine, efficiently enhances the cellular uptake through different mechanisms. The cellular uptake and internalization of many CPPs along with the conjugated cargo occurs predominantly by an endocytic pathway that involves macropinocytosis, a caveolae pathway, clathrin-mediated endocytosis, or lipid-raft dependent endocytosis. Endosomal uptake represents a major challenge in targeted intracellular drug delivery since some compounds are trapped in endosomes and cannot reach the biological targets in the cytoplasm or nucleus. Thus, strategies that promote endosomal escape or avoid endosomal routes are required for improving bioavailability. Moreover, the nuclear delivery of cell-impermeable and water-insoluble molecules remains a major challenge. The nucleus is a desirable target because the genetic information of the cell and transcription machinery resides there. To date, most approaches for nuclear delivery of compounds have taken advantage of covalent conjugation, which requires release of the cargo from the conjugate and/or endosomal escape. There is therefore a need to develop alternative stable peptide carriers that avoid endosomal pathways and/or covalent conjugation. Compared to linear peptides that are susceptible to hydrolysis by endogenous peptidases, cyclic peptides are enzymatically more stable. The cell-penetrating properties and application of homochiral l-cyclic peptides in drug delivery remain unexplored. Previous studies on linear CPPs by our research group and others indicated that an optimal balance of positive charge and hydrophobicity is required for interactions with the cell membrane and deep penetration into the lipid bilayer. 4,8–10] Herein, we report the design and evaluation of amphipathic homochiral l-cyclic peptides for potential applications as CPPs and/or as molecular transporters of bioactive compounds. Eleven cyclic peptides, namely [WR]4, [FK]4, [AK]4, [EL]4, [RFEF]2, [EK]4, [ER]4, [FR]4, [RFE]3, [WR]3, and [WR]5 (Scheme 1), which contain l-amino acids, were synthesized by employing 9-fluorenylmethyloxycarbonyl (Fmoc) based peptide chemistry. The selection of the cyclic peptides was based on the presence of hydrophobic residues (e.g., W, F, L) and charged residues (e.g., K, R, E). We hypothesized that an optimal amphipathic cyclic peptide that contains appropriate residues, and that undergoes intermolecular and intramolecular interactions can act as a CPP and/or entrap and deliver a bioactive compound intracellularly. To examine the potential application of the cyclic peptides as molecular transporters, a model experiment was performed with lamivudine (( )-2’,3’-dideoxy-3’-thiacytidine, 3TC). 3TC is a nucleoside reverse transcriptase inhibitor that blocks HIV-1 and hepatitis B virus replication. The efficient cellular uptake of 3TC is critical for effective antiviral activity. To monitor the molecular transport ability of the cyclic peptides, a carboxyfluorescein derivative of 3TC (F-3TC) was synthesized. The cellular uptake of the fluorescently labeled 3TC (F3TC) was examined in the leukemia CCRF-CEM cell line in the presence or absence of cyclic peptides. After 1 h incubation at 37 8C, the cells were treated with trypsin to remove the cell-surface-bound drug. The cellular uptake of F3TC was monitored by fluorescence-activated cell sorting (FACS; Figure 1a) and fluorescence microscopy (Figure 1b). The cyclic peptides did not exhibit any cytotoxicity by using an MTT assay at an experimental concentration of 50 mm in four different cell lines, namely CCRF-CEM, HT-29, MDAMD-468, and SK-OV-3, thus showing consistent results (Figure S12). FACS and fluorescence microscopy showed significantly higher fluorescence signals in the cells treated with F-3TCloaded [WR]4 and [WR]5 compared to those treated with other F-3TC-loaded cyclic peptides and with F-3TC alone, thus suggesting that the uptake of F-3TC is facilitated by [WR]n (n = 4, 5) and is dependent on nature of amino acids. F3TC-loaded [WR]5 exhibited a cellular uptake that was approximately five times higher than that of F-3TC alone (Figure 1a). Phosphopeptides are valuable probes for studying phosphoprotein–protein interactions because these peptides mimic the interactions between the negatively charged phosphate group of phosphoproteins and positively charged amino acids in the binding pockets of a number of proteins. Studying negatively charged phosphopeptides in cellular systems is challenging because these peptides do not readily [*] Dr. D. Mandal, A. Nasrolahi Shirazi, Prof. K. Parang Department of Biomedical and Pharmaceutical Sciences University of Rhode Island 41 Lower College Road, Kingston, RI 02881 (USA) E-mail: kparang@uri.edu

The Effect of Process and Formulation Variables on the Properties of Spray‐dried β‐Galactosidase

Abstract: The objective of this study was to evaluate the joint effects of various processing and formulation variables on the properties of spray-dried beta-galactosidase using statistically designed experiments. The key response variables evaluated were product yield, residual enzymatic activity, moisture content and particle size and appearance. The residual enzymatic activity and product yield were significantly affected by the processing variables. The highest product yields were obtained when the drier outlet temperature was relatively high, resulting in extensive protein denaturation. Subsequent experiments, therefore, compared the relative effectiveness of four stabilizers (mannitol, sucrose, arginine hydrochloride and trehalose) in terms of their ability to preserve enzymatic activity during the spray-drying process and during long-term storage. Trehalose was the most suitable stabilizer. The effect of a number of other formulation variables (total solids level, ratio of stabilizer to protein, presence of surfactant and presence of buffer) was also investigated. A final formulation consisting of 6% beta-galactosidase and 10% trehalose in deionized water was selected. Spray-drying at inlet and outlet temperatures of 140 and 95 degrees C, respectively, results in greater than 70% yields of a fully active product with a moisture content of 2-5% and a mean particle size of 2-4 microns.

ADHD in the Classroom: Effective Intervention Strategies

Abstract: School-related difficulties are commonly associated with attention deficit hyperactivity disorder (ADHD). This article describes effective school-based intervention strategies including behavioral interventions, modifications to academic instruction, and home-school communication programs. One overlooked aspect of treatment of children with ADHD is the need to form partnerships among school professionals who can work collaboratively on interventions for children with ADHD. Approaches to developing effective collaboration between teachers and school psychologists are presented. Multiple treatment strategies implemented in a consistent fashion across school years can optimize the school success of students with ADHD.

Sustained monitoring of the southern ocean at drake passage: past achievements and future priorities

Abstract: Drake Passage is the narrowest constriction of the Antarctic Circumpolar Current (ACC) in the Southern Ocean, with implications for global ocean circulation and climate. We review the long-term sustained monitoring programs that have been conducted at Drake Passage, dating back to the early part of the twentieth century. Attention is drawn to numerous breakthroughs that have been made from these programs, including (1) the first determinations of the complex ACC structure and early quantifications of its transport; (2) realization that the ACC transport is remarkably steady over interannual and longer periods, and a growing understanding of the processes responsible for this; (3) recognition of the role of coupled climate modes in dictating the horizontal transport and the role of anthropogenic processes in this; and (4) understanding of mechanisms driving changes in both the upper and lower limbs of the Southern Ocean overturning circulation and their impacts. It is argued that monitoring of this passage remains a high priority for oceanographic and climate research but that strategic improvements could be made concerning how this is conducted. In particular, long-term programs should concentrate on delivering quantifications of key variables of direct relevance to large-scale environmental issues: In this context, the time-varying overturning circulation is, if anything, even more compelling a target than the ACC flow. Further, there is a need for better international resource sharing and improved spatiotemporal coordination of the measurements. If achieved, the improvements in understanding of important climatic issues deriving from Drake Passage monitoring can be sustained into the future.

The Generation and Evolution of Nonlinear Internal Waves in the Deep Basin of the South China Sea

Abstract: Time series observations of nonlinear internal waves in the deep basin of the South China Sea are used to evaluate mechanisms for their generation and evolution. Internal tides are generated by tidal currents over ridges in Luzon Strait and steepen as they travel west, subsequently generating high-frequency nonlinear waves. Although nonlinear internal waves appear repeatedly on the western slopes of the South China Sea, their appearance in the deep basin is intermittent and more closely related to the amplitude of the semidiurnal than the predominant diurnal tidal current in Luzon Strait. As the internal tide propagates westward, it evolves under the influence of nonlinearity, rotation, and nonhydrostatic dispersion. The interaction between nonlinearity and rotation transforms the internal tide into a parabolic or corner shape. A fully nonlinear two-layer internal wave model explains the observed characteristics of internal tide evolution in the deep basin for different representative forcing cond...

Examining the effect of teachers' adaptations of a middle school science inquiry-oriented curriculum unit on student learning

Abstract: Reform based curriculum offer a promising avenue to support greater student achievement in science Yet teachers frequently adapt innovative curriculum when they use them in their own classrooms In this study, we examine how 19 teachers adapted an inquiry-oriented middle school science curriculum Specifically, we investigate how teachers' curricular adaptations (amount of time, level of completion, and activity structures), teacher self-efficacy (teacher comfort and student understanding), and teacher experience enacting the unit influenced student learning Data sources included curriculum surveys, videotape observations of focal teachers, and pre- and post-tests from 1,234 students Our analyses using hierarchical linear modeling found that 38% of the variance in student gain scores occurred between teachers Two variables significantly predicted student learning: teacher experience and activity structure Teachers who had previously taught the inquiry-oriented curriculum had greater student gains For activity structure, students who completed inves- tigations themselves had greater learning gains compared to students in classrooms who observed their teacher completing the investigations as demonstrations These findings suggest that it can take time for teachers to effectively use innovative science curriculum Furthermore, this study provides evidence for the importance of having students actively engaging in inquiry investigations to develop understandings of key science concepts 2010 Wiley Periodicals, Inc J Res Sci Teach 48: 149-169, 2011

Evidence for aggregation and export of cyanobacteria and nano-eukaryotes from the Sargasso Sea euphotic zone

Abstract: . Pico-plankton and nano-plankton are generally thought to represent a negligible fraction of the total particulate organic carbon (POC) export flux in oligotrophic gyres due to their small size, slow individual sinking rates, and tight grazer control that leads to high rates of recycling in the euphotic zone. Based upon recent inverse modeling and network analysis however, it has been hypothesized that pico-plankton, including the cyanobacteria Synechococcus and Prochlorococcus, and nano-plankton contribute significantly to POC export, via formation and gravitational settling of aggregates and/or consumption of those aggregates by mesozooplankton, in proportion to their contribution to net primary production. This study presents total suspended particulate (>0.7 μm) and particle size-fractionated (10–20 μm, 20–53 μm, >53 μm) pigment concentrations from within and below the euphotic zone in the oligotrophic subtropical North Atlantic, collected using Niskin bottles and large volume in-situ pumps, respectively. Results show the indicator pigments for Synechococcus, Prochlorococcus and nano-eukaryotes are; (1) found at depths down to 500 m, and; (2) essentially constant, relative to the sum of all indicator pigments, across particle size fractions ranging from 10 μm to >53 μm. Based upon the presence of chlorophyll precursor and degradation pigments, and that in situ pumps do not effectively sample fecal pellets, it is concluded that these pigments were redistributed to deeper waters on larger, more rapidly sinking aggregates likely by gravitational settling and/or convective mixing. Using available pigment and ancillary data from these cruises, these Synechococcus, Prochlorococcus and nano-plankton derived aggregates are estimated to contribute 2–13% (5 ± 4%), 1–20% (5 ± 7%), and 6–43% (23 ± 14%) of the total sediment trap POC flux measured on the same cruises, respectively. Furthermore, nano-eukaryotes contribute equally to POC export and autotrophic biomass, while cyanobacteria contributions to POC export are one-tenth of their contribution to autotrophic biomass. These field observations provide direct evidence that pico- and nano-plankton represent a significant contribution to the total POC export via formation of aggregates in this oligotrophic ocean gyre. We suggest that aggregate formation and fate should be included in ecosystem models, particularly as oligotrophic regions are hypothesized to expand in areal extent with warming and increased stratification in the future.