Institution
University of Rhode Island
Education•Kingston, Rhode Island, United States•
About: University of Rhode Island is a education organization based out in Kingston, Rhode Island, United States. It is known for research contribution in the topics: Population & Bay. The organization has 11464 authors who have published 22770 publications receiving 841066 citations. The organization is also known as: URI & Rhode Island College of Agriculture and the Mechanic Arts.
Topics: Population, Bay, Poison control, Transtheoretical model, Behavior change
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Canadian Institute for Advanced Research1, University of British Columbia2, Monterey Bay Aquarium Research Institute3, Stony Brook University4, University of California, San Diego5, Brown University6, Marine Biological Laboratory7, University of Washington8, Dalhousie University9, National Center for Genome Resources10, Alfred Wegener Institute for Polar and Marine Research11, Rutgers University12, Texas A&M University13, University of Southern California14, University of Delaware15, Victoria University of Wellington16, University of Paris-Sud17, Columbia University18, University of Oslo19, University of Hawaii at Manoa20, University of Prince Edward Island21, University of Rhode Island22, Woods Hole Oceanographic Institution23, Jacobs University Bremen24, Max Planck Society25, Smith College26, University of South Alabama27, Saint Petersburg State University28, University of Geneva29, University of Connecticut30, Laval University31, University of Guelph32, University of North Carolina at Chapel Hill33, University of New Brunswick34, University of Camerino35, University of East Anglia36, Stazione Zoologica Anton Dohrn37, University of Georgia38, University of Technology, Sydney39, University of Puerto Rico40, University of Pisa41, Centre national de la recherche scientifique42, Colorado School of Mines43, Lund University44, University of Western Ontario45, California State University46, University of Texas at Austin47, Los Alamos National Laboratory48, Pierre-and-Marie-Curie University49, University of Oklahoma50, Plymouth Marine Laboratory51, Bigelow Laboratory For Ocean Sciences52, Princeton University53
TL;DR: In this paper, the authors describe a resource of 700 transcriptomes from marine microbial eukaryotes to help understand their role in the world's oceans and their biology, evolution, and ecology.
Abstract: Current sampling of genomic sequence data from eukaryotes is relatively poor, biased, and inadequate to address important questions about their biology, evolution, and ecology; this Community Page describes a resource of 700 transcriptomes from marine microbial eukaryotes to help understand their role in the world's oceans.
852 citations
844 citations
TL;DR: The weight of the evidence supports the continued value of cholinergic drugs as a standard, cornerstone pharmacological approach in Alzheimer's disease, particularly as the authors look ahead to future combination therapies that address symptoms as well as disease progression.
Abstract: Cholinergic synapses are ubiquitous in the human central nervous system. Their high density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic transmission is likely to be critically important for memory, learning, attention and other higher brain functions. Several lines of research suggest additional roles for cholinergic systems in overall brain homeostasis and plasticity. As such, the brain's cholinergic system occupies a central role in ongoing research related to normal cognition and age-related cognitive decline, including dementias such as Alzheimer's disease. The cholinergic hypothesis of Alzheimer's disease centres on the progressive loss of limbic and neocortical cholinergic innervation. Neurofibrillary degeneration in the basal forebrain is believed to be the primary cause for the dysfunction and death of forebrain cholinergic neurons, giving rise to a widespread presynaptic cholinergic denervation. Cholinesterase inhibitors increase the availability of acetylcholine at synapses in the brain and are one of the few drug therapies that have been proven clinically useful in the treatment of Alzheimer's disease dementia, thus validating the cholinergic system as an important therapeutic target in the disease. This review includes an overview of the role of the cholinergic system in cognition and an updated understanding of how cholinergic deficits in Alzheimer's disease interact with other aspects of disease pathophysiology, including plaques composed of amyloid-β proteins. This review also documents the benefits of cholinergic therapies at various stages of Alzheimer's disease and during long-term follow-up as visualized in novel imaging studies. The weight of the evidence supports the continued value of cholinergic drugs as a standard, cornerstone pharmacological approach in Alzheimer's disease, particularly as we look ahead to future combination therapies that address symptoms as well as disease progression.
821 citations
TL;DR: A hierarchical model which integrates the previously competing models provided the best fit to the data and serves to explain a large body of previous findings.
812 citations
TL;DR: The concentration of airborne soil dust at Enewetak Atoll in April 1979 was 2.3 micrograms per cubic meter but decreased steadily to 0.02 microgramper cubic meter over the next 5 months, suggesting that the spring dust is probably derived from China.
Abstract: The concentration of airborne soil dust at Enewetak Atoll(11°N, 162°E) in April 1979 was 2.3 micrograms per cubic meter but decreased steadily to 0.02 microgram per cubic meter over the next 5 months. The spring dust is probably derived from China; its deposition rate (∼0.3 millimeter per 1000 years) suggests that it may be a significant contributor to the deep-sea sediments of the North Pacific.
805 citations
Authors
Showing all 11569 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| James M. Tiedje | 150 | 688 | 102287 |
| Roberto Kolter | 120 | 315 | 52942 |
| Robert S. Stern | 120 | 761 | 62834 |
| Michael S. Feld | 119 | 552 | 51968 |
| William C. Sessa | 117 | 383 | 52208 |
| Kenneth H. Mayer | 115 | 1351 | 64698 |
| Staffan Kjelleberg | 114 | 425 | 44414 |
| Kevin C. Jones | 114 | 744 | 50207 |
| David R. Nelson | 110 | 615 | 66627 |
| Peter K. Smith | 107 | 855 | 49174 |
| Peter M. Groffman | 106 | 457 | 40165 |
| Ming Li | 103 | 1669 | 62672 |
| Victor Nizet | 102 | 564 | 44193 |
| Anil Kumar | 99 | 2124 | 64825 |
| James O. Prochaska | 97 | 320 | 73265 |