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Institution

University of Rhode Island

EducationKingston, Rhode Island, United States
About: University of Rhode Island is a education organization based out in Kingston, Rhode Island, United States. It is known for research contribution in the topics: Population & Bay. The organization has 11464 authors who have published 22770 publications receiving 841066 citations. The organization is also known as: URI & Rhode Island College of Agriculture and the Mechanic Arts.


Papers
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Journal ArticleDOI
TL;DR: An intercomparison was conducted between 14 different cross-flow filtration (CFF) systems, and five different manufacturers' membranes were tested as discussed by the authors, with the goal of examining whether the different CFF systems were behaving in a well-defined and operationally reproducible manner in marine applications.

182 citations

Journal ArticleDOI
TL;DR: The role of T-cell-dependent (Td) immunogenicity assessment in the preclinical and clinical phases of drug development and new data on regulatory T- cell epitopes contained in the Fc and CH1 domains of IgG are summarized.

182 citations

Journal ArticleDOI
TL;DR: Loss of boundary-lubricating ability of SF after injury is associated with damage to the articular cartilage matrix, particularly in the early phases, and this association also exists in patients with acute knee injuries or progressive chronic inflammatory arthritis.
Abstract: Objective To study the relationship between the boundary-lubricating ability of synovial fluid (SF) and articular cartilage damage in a rabbit knee injury model, to correlate collagen markers of such damage with SF boundary-lubricating ability and elastase activity, and to examine the lubricating ability of SF, together with collagen markers of articular cartilage damage, under the inflammatory conditions of knee joint synovitis (KJS) and rheumatoid arthritis (RA). Methods SF was aspirated weekly from the affected knee joints of 10 adult rabbits following transection of the anterior and posterior cruciate ligaments. The boundary-lubricating ability of SF was determined in vitro using a previously described friction apparatus. Lubricin concentrations and type II collagen (CII) peptides were quantified by sandwich enzyme-linked immunosorbent assays (ELISAs). Levels of the C-terminal neoepitope 9A4 (derived from collagenase degradation of CI, CII, and CIII) and of epitope 5-D-4 of keratan sulfate (a marker of proteoglycan depletion) were quantified by inhibition ELISAs. Elastase activity was measured spectrophotometrically. The sensitivity of purified human lubricin to digestion by neutrophil elastase (NE) was examined by Western blotting. Results The lubricating ability of SF from injured rabbit knees was significantly decreased at weeks 2 and 3 compared with week 1 after injury. Lubricin concentrations were significantly higher at week 1 than at weeks 2 and 3. CII peptide concentrations increased significantly at weeks 2 and 3 compared with week 1, while 9A4 neoepitope concentrations increased significantly at week 3 compared with weeks 1 and 2. There were no significant differences in epitope 5-D-4 concentrations among the 3 weeks. Elastase activity in SF increased significantly at weeks 2 and 3 compared with week 1. Elastase activity correlated significantly with diminishing lubrication at weeks 1, 2, and 3. SF from patients with KJS or RA exhibited deficient lubrication and elevated levels of CII peptides compared with SF from normal controls. NE was shown to completely degrade purified human lubricin in vitro. Conclusion Loss of boundary-lubricating ability of SF after injury is associated with damage to the articular cartilage matrix. This can be attributed to inflammatory processes resulting from the injury, particularly in the early phases. This association also exists in patients with acute knee injuries or progressive chronic inflammatory arthritis.

182 citations

Journal ArticleDOI
TL;DR: In this paper, a method was developed for the selective enumeration of F male-specific bacteriophages in samples of environmental waters, and the F malespecific phage levels in prechlorinated, secondary-treated sewage effluents generally were about 10(3) to 10(4) PFU/100 ml.
Abstract: A method was developed for the selective enumeration of F male-specific bacteriophages in samples of environmental waters. The host strain for the phages, Escherichia coli HS(pFamp)R, has three antibiotic resistance markers, ampicillin on the Famp plasmid, which codes for pilus production, and streptomycin and nalidixic acid on the chromosome. The strain is resistant to coliphages T2 to T7 and phi X174. More than 95% of the phages from environmental samples which plaqued on the host strain were F male specific. The host bacterium had a higher plaquing efficiency than E. coli K-12 Hfr for F-specific phages in stock suspensions and sewage effluents. The F male-specific phage levels in prechlorinated, secondary-treated sewage effluents generally were about 10(3) to 10(4) PFU/100 ml. The levels in the influents to the sewage treatment plants and in septic tank contents were about 10(5) PFU/100 ml. RNA-containing phages composed about 90% of the total F-specific phage population in sewage effluents.

182 citations

Journal ArticleDOI
TL;DR: The authors examined the contributions of orientations to happiness (pleasure, engagement and meaning) to subjective well-being and found that meaning and engagement explained the greatest variance in all three components of subjective wellbeing.
Abstract: This study examined the contributions of orientations to happiness (pleasure, engagement and meaning) to subjective well-being. A sample of 12,622 adults from the United States completed on-line surveys measuring orientations to happiness, positive affect, negative affect, and life satisfaction. A sample of 332 adults from Australia also completed these surveys as well as a measure of the big five factor personality traits. Hierarchical regressions generally supported the hypothesis that the three orientations to happiness predict subjective well-being (satisfaction with life, positive affect and negative affect) beyond sociodemographic variables and personality. Meaning and engagement explained the greatest variance in all three components of subjective well-being. Overall, these findings support the importance of a eudaimonic approach in addition to the hedonic approach to achieving happiness. Moreover, findings were relatively consistent in both the Australian and US samples.

182 citations


Authors

Showing all 11569 results

NameH-indexPapersCitations
James M. Tiedje150688102287
Roberto Kolter12031552942
Robert S. Stern12076162834
Michael S. Feld11955251968
William C. Sessa11738352208
Kenneth H. Mayer115135164698
Staffan Kjelleberg11442544414
Kevin C. Jones11474450207
David R. Nelson11061566627
Peter K. Smith10785549174
Peter M. Groffman10645740165
Ming Li103166962672
Victor Nizet10256444193
Anil Kumar99212464825
James O. Prochaska9732073265
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202344
2022161
20211,105
20201,058
2019996
2018888