Institution
University of Rhode Island
Education•Kingston, Rhode Island, United States•
About: University of Rhode Island is a education organization based out in Kingston, Rhode Island, United States. It is known for research contribution in the topics: Population & Bay. The organization has 11464 authors who have published 22770 publications receiving 841066 citations. The organization is also known as: URI & Rhode Island College of Agriculture and the Mechanic Arts.
Topics: Population, Bay, Poison control, Transtheoretical model, Behavior change
Papers published on a yearly basis
Papers
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Woods Hole Oceanographic Institution1, College of William & Mary2, University of Massachusetts Boston3, Massachusetts Institute of Technology4, Florida State University5, Washington State University6, University of Rhode Island7, Texas A&M University8, University of California, San Diego9, University of California, Santa Cruz10
TL;DR: An intercomparison was conducted between 14 different cross-flow filtration (CFF) systems, and five different manufacturers' membranes were tested as discussed by the authors, with the goal of examining whether the different CFF systems were behaving in a well-defined and operationally reproducible manner in marine applications.
182 citations
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TL;DR: The role of T-cell-dependent (Td) immunogenicity assessment in the preclinical and clinical phases of drug development and new data on regulatory T- cell epitopes contained in the Fc and CH1 domains of IgG are summarized.
182 citations
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TL;DR: Loss of boundary-lubricating ability of SF after injury is associated with damage to the articular cartilage matrix, particularly in the early phases, and this association also exists in patients with acute knee injuries or progressive chronic inflammatory arthritis.
Abstract: Objective
To study the relationship between the boundary-lubricating ability of synovial fluid (SF) and articular cartilage damage in a rabbit knee injury model, to correlate collagen markers of such damage with SF boundary-lubricating ability and elastase activity, and to examine the lubricating ability of SF, together with collagen markers of articular cartilage damage, under the inflammatory conditions of knee joint synovitis (KJS) and rheumatoid arthritis (RA).
Methods
SF was aspirated weekly from the affected knee joints of 10 adult rabbits following transection of the anterior and posterior cruciate ligaments. The boundary-lubricating ability of SF was determined in vitro using a previously described friction apparatus. Lubricin concentrations and type II collagen (CII) peptides were quantified by sandwich enzyme-linked immunosorbent assays (ELISAs). Levels of the C-terminal neoepitope 9A4 (derived from collagenase degradation of CI, CII, and CIII) and of epitope 5-D-4 of keratan sulfate (a marker of proteoglycan depletion) were quantified by inhibition ELISAs. Elastase activity was measured spectrophotometrically. The sensitivity of purified human lubricin to digestion by neutrophil elastase (NE) was examined by Western blotting.
Results
The lubricating ability of SF from injured rabbit knees was significantly decreased at weeks 2 and 3 compared with week 1 after injury. Lubricin concentrations were significantly higher at week 1 than at weeks 2 and 3. CII peptide concentrations increased significantly at weeks 2 and 3 compared with week 1, while 9A4 neoepitope concentrations increased significantly at week 3 compared with weeks 1 and 2. There were no significant differences in epitope 5-D-4 concentrations among the 3 weeks. Elastase activity in SF increased significantly at weeks 2 and 3 compared with week 1. Elastase activity correlated significantly with diminishing lubrication at weeks 1, 2, and 3. SF from patients with KJS or RA exhibited deficient lubrication and elevated levels of CII peptides compared with SF from normal controls. NE was shown to completely degrade purified human lubricin in vitro.
Conclusion
Loss of boundary-lubricating ability of SF after injury is associated with damage to the articular cartilage matrix. This can be attributed to inflammatory processes resulting from the injury, particularly in the early phases. This association also exists in patients with acute knee injuries or progressive chronic inflammatory arthritis.
182 citations
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TL;DR: In this paper, a method was developed for the selective enumeration of F male-specific bacteriophages in samples of environmental waters, and the F malespecific phage levels in prechlorinated, secondary-treated sewage effluents generally were about 10(3) to 10(4) PFU/100 ml.
Abstract: A method was developed for the selective enumeration of F male-specific bacteriophages in samples of environmental waters. The host strain for the phages, Escherichia coli HS(pFamp)R, has three antibiotic resistance markers, ampicillin on the Famp plasmid, which codes for pilus production, and streptomycin and nalidixic acid on the chromosome. The strain is resistant to coliphages T2 to T7 and phi X174. More than 95% of the phages from environmental samples which plaqued on the host strain were F male specific. The host bacterium had a higher plaquing efficiency than E. coli K-12 Hfr for F-specific phages in stock suspensions and sewage effluents. The F male-specific phage levels in prechlorinated, secondary-treated sewage effluents generally were about 10(3) to 10(4) PFU/100 ml. The levels in the influents to the sewage treatment plants and in septic tank contents were about 10(5) PFU/100 ml. RNA-containing phages composed about 90% of the total F-specific phage population in sewage effluents.
182 citations
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TL;DR: The authors examined the contributions of orientations to happiness (pleasure, engagement and meaning) to subjective well-being and found that meaning and engagement explained the greatest variance in all three components of subjective wellbeing.
Abstract: This study examined the contributions of orientations to happiness (pleasure, engagement and meaning) to subjective well-being. A sample of 12,622 adults from the United States completed on-line surveys measuring orientations to happiness, positive affect, negative affect, and life satisfaction. A sample of 332 adults from Australia also completed these surveys as well as a measure of the big five factor personality traits. Hierarchical regressions generally supported the hypothesis that the three orientations to happiness predict subjective well-being (satisfaction with life, positive affect and negative affect) beyond sociodemographic variables and personality. Meaning and engagement explained the greatest variance in all three components of subjective well-being. Overall, these findings support the importance of a eudaimonic approach in addition to the hedonic approach to achieving happiness. Moreover, findings were relatively consistent in both the Australian and US samples.
182 citations
Authors
Showing all 11569 results
Name | H-index | Papers | Citations |
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James M. Tiedje | 150 | 688 | 102287 |
Roberto Kolter | 120 | 315 | 52942 |
Robert S. Stern | 120 | 761 | 62834 |
Michael S. Feld | 119 | 552 | 51968 |
William C. Sessa | 117 | 383 | 52208 |
Kenneth H. Mayer | 115 | 1351 | 64698 |
Staffan Kjelleberg | 114 | 425 | 44414 |
Kevin C. Jones | 114 | 744 | 50207 |
David R. Nelson | 110 | 615 | 66627 |
Peter K. Smith | 107 | 855 | 49174 |
Peter M. Groffman | 106 | 457 | 40165 |
Ming Li | 103 | 1669 | 62672 |
Victor Nizet | 102 | 564 | 44193 |
Anil Kumar | 99 | 2124 | 64825 |
James O. Prochaska | 97 | 320 | 73265 |