University of Rijeka

About: University of Rijeka is a education organization based out in Rijeka, Croatia. It is known for research contribution in the topics: Population & Tourism. The organization has 3471 authors who have published 7993 publications receiving 110386 citations. The organization is also known as: Rijeka University & Sveučilište u Rijeci.

Contemporaneous observations of the radio galaxy NGC 1275 from radio to very high energy gamma-rays

Abstract: The radio galaxy NGC 1275, recently identified as a very high energy (VHE, >100 GeV) gamma-ray emitter by MAGIC, is one of the few non-blazar AGN detected in the VHE regime. In order to better understand the origin of the gamma-ray emission and locate it within the galaxy, we studied contemporaneous multi-frequency observations of NGC 1275 and modeled the overall spectral energy distribution (SED). We analyzed unpublished MAGIC observations carried out between Oct. 2009 and Feb. 2010, and the previously published ones taken between Aug. 2010 and Feb. 2011. We studied the multi-band variability and correlations by analyzing data of Fermi-LAT (0.1-100 GeV), as well as Chandra (X-ray), KVA (optical) and MOJAVE (radio) data taken during the same period. Using customized Monte Carlo simulations corresponding to early MAGIC stereo data, we detect NGC 1275 also in the earlier campaign. The flux level and energy spectra are similar to the results of the second campaign. The monthly light curve >100 GeV shows a hint of variability at the 3.6 sigma level. In the Fermi-LAT band, both flux and spectral shape variabilities are reported. The optical light curve is variable and shows a clear correlation with the gamma-ray flux >100 MeV. In radio, 3 compact components are resolved in the innermost part of the jet. One of them shows a similar trend as the LAT and KVA light curves. The 0.1-650 GeV spectra measured simultaneously with MAGIC and Fermi-LAT can be well fitted either by a log-parabola or by a power-law with a sub-exponential cutoff for both campaigns. A single-zone synchrotron-self-Compton model, with an electron spectrum following a power-law with an exponential cutoff, can explain the broadband SED and the multi-band behavior of the source. However, this model suggests an untypical low bulk-Lorentz factor or a velocity alignment closer to the line of sight than the pc-scale radio jet.

Is crying a self-soothing behavior?

Abstract: This contribution describes the current state-of-the-art of the scientific literature regarding the self-soothing effects of crying. Starting from the general hypothesis that crying is a self-soothing behavior, we consider different mechanisms through which these effects may appear. In the first section, we briefly explain the main functions of human crying. Then we define self-soothing in terms of homeostatic processes of mood regulation and stress reduction and we underline the importance of distinguishing self-soothing effects of crying from social-soothing that it may elicit. We then provide a comprehensive review of the putative mood-enhancing and -relieving effects of crying and their variations stemming from characteristics of crying person, antecedents, manifestations, and social consequences of crying. We also discuss the possible methodological explanations for the seemingly discrepant findings regarding mood improvement and relief that may follow crying. We then provide theoretical and empirical support for our general hypothesis that crying is a self-soothing behavior by presenting and evaluating the possible physiological, cognitive, and behavioral mechanisms that may play a mediating role in the relationship between crying and homeostatic regulation that includes mood improvement and relief. Starting from the idea that social-soothing and self-soothing mechanisms share the same physiological systems, we propose that biological processes act in parallel with learning and reappraisal processes that accompany crying, which results in homeostatic regulation. Given the parallels between self-soothing behaviors in humans and animals, we also propose that crying might self-soothe through a mechanism that shares key properties with rhythmical, stereotypic behaviors. We conclude that, in addition to the importance of socially mediated mechanisms for the mood-enhancing effects of crying, there is converging evidence for the direct, self-soothing effects of crying.

Novel diamidino-substituted derivatives of phenyl benzothiazolyl and dibenzothiazolyl furans and thiophenes: synthesis, antiproliferative and DNA binding properties.

Abstract: A series of new diamidino-, diisopropylamidino-, and diimidazolinyl-substituted derivatives of phenyl benzothiazolyl and dibenzothiazolyl furans and thiophenes were successfully prepared and evaluated for their antiproliferative activity on tumor cell lines in vitro, DNA binding propensity, and sequence selectivity as well as cellular distribution. A strong antiproliferative effect of the tested compounds was observed on all tested cell lines in a concentration-dependent response pattern. In general, imidazolinyl-substituted derivatives and/or the thiophene core were in correlation with increased antiproliferative activity. Two compounds (2b and 3b) were chosen for biological studies due to their differential antiproliferative properties. The DNA binding properties of this new series of compounds were assessed and evidenced their efficient minor groove binding properties with preferential interaction at AT-rich sites. Both compounds also present nuclear subcellular localization, suggesting that their cellular mode of action implies localization in the DNA compartment and direct inhibition of DNA replication and induction of apoptosis.