University of Rijeka

About: University of Rijeka is a education organization based out in Rijeka, Croatia. It is known for research contribution in the topics: Population & Tourism. The organization has 3471 authors who have published 7993 publications receiving 110386 citations. The organization is also known as: Rijeka University & Sveučilište u Rijeci.

Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection.

Abstract: An O-antigen-specific murine monoclonal antibody (MAb) directed against an immunodominant epitope expressed on Klebsiella O1, O6, and O8 lipopolysaccharides (LPS) was examined with respect to its binding to nonencapsulated and encapsulated bacterial cells and its ability to protect against lethal murine Klebsiella sepsis. While the MAb (clone Ru-O1, mouse immunoglobulin G2b) bound well to nonencapsulated organisms of the O1 serogroup, binding was significantly, but not completely, abolished by the presence of the K2 capsule. In a model of experimental Klebsiella peritonitis and sepsis induced by a virulent O1:K2 serogroup strain, higher doses of anti-LPS MAb Ru-O1 than of a previously described anticapsular MAb specific for the K2 capsular polysaccharide were needed to provide protection. However, high-dose (40 microg/g of body weight) pretreatment with anti-LPS MAb Ru-O1 significantly reduced bacterial dissemination to various organs as well as macroscopic and histologic pulmonary alterations. Thus, since the number of Klebsiella capsular antigens occurring in clinical material is too large to be completely "covered" by a K-antigen-specific hyperimmunoglobulin preparation, O-antigen-specific antibodies may supplement K-antigen-specific immunoprophylaxis and -therapy of clinical Klebsiella infection.

Biology of the Corpus luteum

Abstract: Corpus luteum (CL) is a small, transient endocrine gland formed following ovulation from the secretory cells of the ovarian follicles. The main function of CL is the production of progesterone, a hormone which regulates various reproductive functions. Progesterone plays a key role in the regulation of the length of estrous cycle and in the implantation of the blastocysts. Preovulatory surge of luteinizing hormone (LH) is crucial for the luteinization of follicular cells and CL maintenance, but there are also other factors which support the CL development and its functioning. In the absence of pregnancy, CL will cease to produce progesterone and induce itself degradation known as luteolysis. This review is designed to provide a short overview of the events during the life span of corpus luteum (CL) and to make an insight in the synthesis and secretion of its main product – progesterone. The major biologic mechanisms involved in CL development, function, and regression will also be discussed.

Discovery of VHE γ-ray emission from the BL Lacertae object B3 2247+381 with the MAGIC telescopes

Abstract: Aims. We study the non-thermal jet emission of the BL Lac object B3 2247+381 during a high optical state. Methods. The MAGIC telescopes observed the source during 13 nights between September 30th and October 30th 2010, collecting a total of 14.2 hours of good quality very high energy (VHE) -ray data. Simultaneous multiwavelength data was obtained with X-ray observations by the Swift satellite and optical R-band observations at the KVA-telescope. We also use high energy -ray (HE, 0.1 GeV‐100 GeV) data from the Fermi satellite. Results. The BL Lac object B3 2247+381 (z=0.119) was detected, for the first time, at VHE -rays at a statistical significance of 5.6 �. A soft VHE spectrum with a photon index of -3.2± 0.6 was determined. No significant short term flux variations were found. We model the spectral energy distribution using a one-zone SSC-model, which can successfully describe our data.