Institution
University of Rijeka
Education•Rijeka, Croatia•
About: University of Rijeka is a education organization based out in Rijeka, Croatia. It is known for research contribution in the topics: Population & Tourism. The organization has 3471 authors who have published 7993 publications receiving 110386 citations. The organization is also known as: Rijeka University & Sveučilište u Rijeci.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: It is reported that host proteasomal degradation of Lys48-linked polyubiquitinated proteins, assembled on the LCV by AnkB, generates amino acids required for intracellular bacterial proliferation.
Abstract: Legionella pneumophila proliferates in environmental amoeba and human cells within the Legionella-containing vacuole (LCV). The exported AnkB F-box effector of L. pneumophila is anchored into the LCV membrane by host-mediated farnesylation. Here, we report that host proteasomal degradation of Lys48-linked polyubiquitinated proteins, assembled on the LCV by AnkB, generates amino acids required for intracellular bacterial proliferation. The severe defect of the ankB null mutant in proliferation within amoeba and human cells is rescued by supplementation of a mixture of amino acids or cysteine, serine, pyruvate, or citrate, similar to rescue by genetic complementation. Defect of the ankB mutant in intrapulmonary proliferation in mice is rescued upon injection of a mixture of amino acids or cysteine. Therefore, Legionella promotes eukaryotic proteasomal degradation to generate amino acids needed as carbon and energy sources for bacterial proliferation within evolutionarily distant hosts.
200 citations
••
13 Feb 2016TL;DR: The results provide new insights into the mechanisms regulating the expression of immune ligands in senescent cells and reveal the importance of NKG2D receptor-ligand interaction in protecting against liver fibrosis.
Abstract: Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue damage. Induction of cellular senescence commonly coincides with an immunogenic phenotype that promotes self-elimination by components of the immune system, thereby facilitating tumor suppression and limiting excess fibrosis during wound repair. The mechanisms by which senescent cells regulate their immune surveillance are not completely understood. Here we show that ligands of an activating Natural Killer (NK) cell receptor (NKG2D), MICA and ULBP2 are consistently up-regulated following induction of replicative senescence, oncogene-induced senescence and DNA damage - induced senescence. MICA and ULBP2 proteins are necessary for efficient NK-mediated cytotoxicity towards senescent fibroblasts. The mechanisms regulating the initial expression of NKG2D ligands in senescent cells are dependent on a DNA damage response, whilst continuous expression of these ligands is regulated by the ERK signaling pathway. In liver fibrosis, the accumulation of senescent activated stellate cells is increased in mice lacking NKG2D receptor leading to increased fibrosis. Overall, our results provide new insights into the mechanisms regulating the expression of immune ligands in senescent cells and reveal the importance of NKG2D receptor-ligand interaction in protecting against liver fibrosis.
200 citations
••
Institut d'Astrophysique de Paris1, Ohio State University2, Princeton University3, Massey University4, Tel Aviv University5, University of Canterbury6, University of St Andrews7, Ames Research Center8, University of Stuttgart9, Niels Bohr Institute10, European Southern Observatory11, Chungbuk National University12, University of Notre Dame13, Chinese Academy of Sciences14, Nagoya University15, University of Auckland16, Victoria University of Wellington17, Konan University18, College of Industrial Technology19, University of the Free State20, University of Tasmania21, Lawrence Livermore National Laboratory22, University of Rijeka23, Vienna University of Technology24, National Institute for Space Research25, NASA Exoplanet Science Institute26, Space Telescope Science Institute27, Heidelberg University28, University of Western Australia29, University of Zielona Góra30, Texas A&M University31, Weizmann Institute of Science32, Technion – Israel Institute of Technology33, Space Science Institute34, Auckland University of Technology35, University of Salerno36, Royal Society37, University of Göttingen38, Aarhus University39, Armagh Observatory40, University of Copenhagen41, University of Sannio42, Sharif University of Technology43, Keele University44, University of Exeter45, Max Planck Society46, Liverpool John Moores University47, Las Cumbres Observatory Global Telescope Network48, University of California, Santa Barbara49
TL;DR: In this article, the authors reported the discovery of a planet with a high planet-to-star mass ratio in the microlensing event MOA-2009-BLG-387, which exhibited pronounced deviations over a 12-day interval.
Abstract: Aims. We report the discovery of a planet with a high planet-to-star mass ratio in the microlensing event MOA-2009-BLG-387, which exhibited pronounced deviations over a 12-day interval, one of the longest for any planetary event. The host is an M dwarf, with a mass in the range 0.07 M_⊙ < M_(host) < 0.49 M_⊙ at 90% confidence. The planet-star mass ratio q = 0.0132 ± 0.003 has been measured extremely well, so at the best-estimated host mass, the planet mass is m_p = 2.6 Jupiter masses for the median host mass, M = 0.19 M_⊙. Methods. The host mass is determined from two “higher order” microlensing parameters. One of these, the angular Einstein radius θ_E = 0.31 ± 0.03 mas has been accurately measured, but the other (the microlens parallax πE, which is due to the Earth’s orbital motion) is highly degenerate with the orbital motion of the planet. We statistically resolve the degeneracy between Earth and planet orbital effects by imposing priors from a Galactic model that specifies the positions and velocities of lenses and sources and a Kepler model of orbits. Results. The 90% confidence intervals for the distance, semi-major axis, and period of the planet are 3.5 kpc < D_L < 7.9 kpc, 1.1 AU < a < 2.7 AU, and 3.8 yr < P < 7.6 yr, respectively.
197 citations
••
TL;DR: The effects of three emerging technologies: high pressure (HP: 500 MPa, 10min), ultrasound (US: 20 kHz, 15min) and tribomechanical activation (TA: 40000rpm) on flowing behavior and thermophysical properties of whey protein isolate (WPI) and wheyprotein concentrate (WPC) were investigated as discussed by the authors.
190 citations
••
TL;DR: When, how and why p53 is activated upon ribosomal biogenesis stress, and how perturbation of this critical regulatory interplay may impact human disease are discussed.
190 citations
Authors
Showing all 3537 results
Name | H-index | Papers | Citations |
---|---|---|---|
Igor Rudan | 142 | 658 | 103659 |
Nikola Godinovic | 138 | 1469 | 100018 |
Ivica Puljak | 134 | 1436 | 97548 |
Damir Lelas | 133 | 1354 | 93354 |
D. Mekterovic | 110 | 449 | 46779 |
Ulrich H. Koszinowski | 96 | 281 | 27709 |
Michele Doro | 79 | 437 | 20090 |
Robert Zivadinov | 73 | 522 | 18636 |
D. Dominis Prester | 70 | 363 | 16701 |
Daniel Ferenc | 70 | 225 | 16145 |
Vladimir Parpura | 64 | 226 | 18050 |
Stipan Jonjić | 62 | 227 | 19363 |
Dario Hrupec | 60 | 288 | 13345 |
Alessandro Laviano | 59 | 298 | 14609 |
Tomislav Terzić | 58 | 271 | 10699 |