University of Rijeka

About: University of Rijeka is a education organization based out in Rijeka, Croatia. It is known for research contribution in the topics: Population & Tourism. The organization has 3471 authors who have published 7993 publications receiving 110386 citations. The organization is also known as: Rijeka University & Sveučilište u Rijeci.

MOA-2010-BLG-311: A planetary candidate below the threshold of reliable detection

Abstract: We analyze MOA-2010-BLG-311, a high magnification (A max > 600) microlensing event with complete data coverage over the peak, making it very sensitive to planetary signals. We fit this event with both a point lens and a two-body lens model and find that the two-body lens model is a better fit but with only Δχ2 ~ 80. The preferred mass ratio between the lens star and its companion is q = 10–3.7 ± 0.1, placing the candidate companion in the planetary regime. Despite the formal significance of the planet, we show that because of systematics in the data the evidence for a planetary companion to the lens is too tenuous to claim a secure detection. When combined with analyses of other high-magnification events, this event helps empirically define the threshold for reliable planet detection in high-magnification events, which remains an open question.

Mast Cells as a Potential Prognostic Marker in Prostate Cancer

Abstract: Despite years of intensive investigation that has been made in understanding prostate cancer, it remains one of the major men's health issues and the leading cause of death worldwide. It is now ascertained that prostate cancer emerges from multiple spontaneous and/or inherited alterations that induce changes in expression patterns of genes and proteins that function in complex networks controlling critical cellular events. It is now accepted that several innate and adaptive immune cells, including T- and B-lymphocytes, macrophages, natural killer cells, dendritic cells, neutrophils, eosinophils, and mast cells (MCs), infiltrate the prostate cancer. All of these cells are irregularly scattered within the tumor and loaded with an assorted array of cytokines, chemokines, and inflammatory and cytotoxic mediators. This complex framework reflects the diversity in tumor biology and tumor-host interactions. MCs are well-established effector cells in Immunoglobulin-E (Ig-E) associated immune responses and potent effector cells of the innate immune system; however, their clinical significance in prostate cancer is still debated. Here, these controversies are summarized, focusing on the implications of these findings in understanding the roles of MCs in primary prostate cancer.

Assessment of sea-level rise impacts on salt-wedge intrusion in idealized and Neretva River Estuary

Abstract: Understanding the response of estuaries to sea-level rise is crucial in developing a suitable mitigation and climate change adaptation strategy. This study investigates the impacts of rising sea levels on salinity intrusion in salt-wedge estuaries. The sea-level rise impacts are assessed in idealized estuaries using simple expressions derived from a two-layer hydraulic theory, and in the Neretva River Estuary in Croatia using a two-layer time-dependent model. The assessment is based on three indicators — the salt-wedge intrusion length, the seawater volume, and the river inflows needed to restore the baseline intrusion. The potential SLR was found to increase all three considered indicators. Theoretical analysis in idealized estuaries suggests that shallower estuaries are more sensitive to SLR. Numerical results for the Neretva River Estuary showed that SLR may increase salt-wedge intrusion length, volume, and corrective river inflow. However, the results are highly non-linear because of the channel geometry, especially for lower river inflows. A theoretical assessment of channel bed slope impacts on limiting a potential intrusion is therefore additionally discussed. This findings emphasize the need to use several different indicators when assessing SLR impacts.

Brain-resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivation.

Abstract: Congenital HCMV infection is a leading infectious cause of long-term neurodevelopmental sequelae. Infection of newborn mice with mouse cytomegalovirus (MCMV) intraperitoneally is a well-established model of congenital human cytomegalovirus infection, which best recapitulates the hematogenous route of virus spread to brain and subsequent pathology. Here, we used this model to investigate the role, dynamics, and phenotype of CD8+ T cells in the brain following infection of newborn mice. We show that CD8+ T cells infiltrate the brain and form a pool of tissue-resident memory T cells (TRM cells) that persist for lifetime. Adoptively transferred virus-specific CD8+ T cells provide protection against primary MCMV infection in newborn mice, reduce brain pathology, and remain in the brain as TRM cells. Brain CD8+ TRM cells were long-lived, slowly proliferating cells able to respond to local challenge infection. Importantly, brain CD8+ TRM cells controlled latent MCMV and their depletion resulted in virus reactivation and enhanced inflammation in brain.