University of Rijeka

About: University of Rijeka is a education organization based out in Rijeka, Croatia. It is known for research contribution in the topics: Population & Tourism. The organization has 3471 authors who have published 7993 publications receiving 110386 citations. The organization is also known as: Rijeka University & Sveučilište u Rijeci.

Macrophage level is not affected by monocyte chemotactic protein-1 in invasive ductal breast carcinoma

Abstract: Purpose and method: Monocyte chemotactic protein-1 (MCP-1) is a chemokine involved in the macrophage infiltration of tumor tissue. Tumor-associated macrophages (TAMs) are a population of mononuclear phagocytic cells that can have a complex function in tumor biology. The aim of this study was to determine the possible correlation between parenchymal MCP-1 expression and TAM level by immunohistochemical analysis of 97 invasive ductal breast carcinomas, not otherwise specified (NOS), and to investigate their relation with tumor size, histological grade, mitotic activity index (MAI) and lymph node status. Secondly, the MCP-1 mRNA was determined by reverse transcriptase–polymerase chain reaction (RT-PCR) in eight samples of normal breast tissue and 27 samples of invasive breast carcinomas and compared with TAMs. Results: MCP-1 immunoreactivity was present in tumor cells (17/97), but also in TAMs, fibroblasts and endothelial cells. The statistical analysis did not show a significant correlation between MCP-1 expression in tumoral epithelium and tumor size, histological grade, MAI, lymph node status or TAMs. The results of RT-PCR showed that, in all cases of breast carcinomas (27/27) and the majority of normal breast tissues (7/8), the number of detected MCP-1 cDNA copies was above the detection limit. However, carcinomas showed higher levels of MCP-1 mRNA than normal breast tissue. Nevertheless, the statistical analysis did not find a significant correlation between MCP-1 expression and macrophage infiltrations. Conclusion: These results indicate that MCP-1 is probably not the only and/or crucial factor involved in macrophage attraction to tumor locus in breast carcinoma.

The SAGE study: global observational analysis of glycaemic control, hypoglycaemia and diabetes management in T1DM

Abstract: Aims: To describe glycaemic control and diabetes management in adults with type 1 diabetes (T1DM), in a real-life global setting. Materials and methods: Study of Adults' GlycEmia (SAGE) was a multinational, multicentre, single visit, non-interventional, cross-sectional study in adult patients with T1DM. Data were collected at a single visit, analysed according to predefined age groups (26-44, 45-64, and ≥65 years), and reported across different regions. The primary endpoint was the proportion of participants achieving HbA1c <7.0 % in each age group. Secondary endpoints included incidence of hypoglycaemia, severe hypoglycaemia and severe hyperglycaemia leading to diabetic ketoacidosis (DKA), and therapeutic management of T1DM. Results: Of 3903 included participants, 3858 (98.8%) were eligible for the study. Overall, 24.3% (95% confidence interval [CI]: 22.9 to 25.6) of participants achieved the glycaemic target of HbA1c <7.0 %, with more participants achieving this target in the 26-44 years group (27.6% [95% CI: 25.5 to 29.8]). Target achievement was highest in Eastern and Western Europe, and lowest in the Middle East. The incidence of hypoglycaemia and of severe hyperglycaemia leading to DKA tended to decrease with age, and varied across regions. Age and regional differences were observed in therapeutic management, including types of device/insulin usage, frequency of insulin dose adjustment, and technology usage. Conclusions: Glycaemic control remains poor in adults with T1DM globally. Several areas of treatment may be optimised to improve outcomes, including supporting patient self-management of insulin therapy, increasing use of technologies such as CGM, and greater provision of healthcare support. This article is protected by copyright. All rights reserved.

Consumers’ behaviour and motives for selection of dairy beverages in Kvarner region: a pilot study

Abstract: Since food choice is always a unique and personal experience, consumer behaviour is important for food manufacturers and marketers in term of product success. Due to the beneficial health-protective effects of dairy beverages, this market segment is very innovative and fast-growing. The aim of this pilot-study was to examine the consumption patterns, purchasing behaviour and motives for choice of dairy beverages. The sample of this study included 114 participants (44 males and 70 females) which were interviewed face-to-face at the entrance of 5 shopping centres. The survey instrument consisted of closed questions regarding habits of consumption, purchasing habits and motives for choice of dairy beverages. Gender specific differences were tested. The results obtained have shown that females consumed more milk and milk drinks (p<0.001) and fermented milk drinks (p=0.002) than males. The consumption of whey-based beverages was sporadical in both genders. Females in higher percentage purchase low-fat dairy beverages (p=0.043), while males exhibited a higher level of loyalty to a certain product (p=0.034). Sensory appeals were the most important motivational factor for both genders. Brand was ranked second for males (p<0.001) and health aspect for females. The products’ origin was ranked third, while price was ranked fifth for both genders. The results obtained could be useful to researchers and dairy market sector in developing and promoting a group of dairy beverage products based on innovations and health.

Optical photometric and spectral study of the new FU Orionis object V2493 Cygni (HBC 722)

Abstract: Aims. We present new results from optical photometric and spectroscopic observations of the eruptive pre-main sequence star V2493 Cyg (HBC 722). The object has continued to undergo significant brightness variations over the past few months and is an ideal target for follow-up observations.Methods. We carried out CCD BVRI photometric observations in the field of V2493 Cyg (“Gulf of Mexico”) from August 1994 to April 2012, i.e. at the pre-outburst states and during the phases of the outburst. We acquired high, medium, and low resolution spectroscopy of V2493 Cyg during the outburst. To study the pre-outburst variability of the target and construct its historical light curve, we searched for archival observations in photographic plate collections. Both CCD and photographic observations were analyzed using 15 comparison stars in the field of V2493 Cyg.Results. The pre-outburst photographic and CCD photometric observations of V2493 Cyg show low-amplitude light variations typical of T Tauri stars. The recent photometric data show a slow light decrease from October 2010 to June 2011 followed by an increase in brightness that continued until early 2012. The spectral observations of V2493 Cyg are typical of FU Orionis stars absorption spectra with strong P Cyg profiles of Hα and Na I D lines. On the basis of photometric monitoring performed over the past two years, the spectral properties at the maximal light, as well as the shape of long-term light curves, we confirm that the observed outburst of V2493 Cyg is of FU Orionis type.