University of Rijeka

About: University of Rijeka is a education organization based out in Rijeka, Croatia. It is known for research contribution in the topics: Population & Tourism. The organization has 3471 authors who have published 7993 publications receiving 110386 citations. The organization is also known as: Rijeka University & Sveučilište u Rijeci.

Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation

Abstract: The transcriptional repressor Blimp-1 mediates the terminal differentiation of many cell types, including T cells Here we identified Hobit (Znf683) as a previously unrecognized homolog of Blimp-1 that was specifically expressed in mouse natural killer T cells (NKT cells) Through studies of Hobit-deficient mice, we found that Hobit was essential for the formation of mature thymic NKT cells In the periphery, Hobit repressed the accumulation of interferon-γ (IFN-γ)-producing NK11(lo) NKT cells at steady state After antigenic stimulation, Hobit repressed IFN-γ expression, whereas after innate stimulation, Hobit induced granzyme B expression Thus, reminiscent of the function of Blimp-1 in other lymphocytes, Hobit controlled the maintenance of quiescent, fully differentiated NKT cells and regulated their immediate effector functions

Recommender System and Web 2.0 Tools to Enhance a Blended Learning Model

Abstract: Blended learning models that combine face-to-face and online learning are of great importance in modern higher education. However, their development should be in line with the recent changes in e-learning that emphasize a student-centered approach and use tools available on the Web to support the learning process. This paper presents research on implementing a contemporary blended learning model within the e-course “Hypermedia Supported Education”. The blended model developed combines a learning management system (LMS), a set of Web 2.0 tools and the E-Learning Activities Recommender System (ELARS) to enhance personalized online learning. As well as incorporating various technologies, the model combines a number of pedagogical approaches, focusing on collaborative and problem-based learning, to ensure the achievement of the course learning outcomes. The results of the comparative study show the effectiveness of the proposed model in that students who performed personalized collaborative e-learning activities achieved better course results. These findings encourage the further application of the model to other computer science courses.

Rapid and multiband variability of the TeV bright active nucleus of the galaxy IC 310

Abstract: Context. The radio galaxy IC 310 has recently been identified as a γ-ray emitter based on observations at GeV energies with Fermi-LAT and at very high energies (VHE, E>100 GeV) with the MAGIC telescopes. Originally classified as a head-tail radio galaxy, the nature of this object is subject of controversy since its nucleus shows blazar-like behavior. Aims. In order to understand the nature of IC 310 and the origin of the VHE emission we studied the spectral and flux variability of IC 310 from the X-ray band to the VHEγ-ray regime. Methods. The light curve of IC 310 above 300 GeV has been measured with the MAGIC telescopes from October 2009 to February 2010. Contemporaneous Fermi-LAT data (2008‐2011) in the 10‐500 GeV energy range were also analyzed. In the X-ray regime, archival observations from 2003 to 2007 with XMM-Newton, Chandra, and Swift-XRT in the 0.5‐10 keV band were studied. Results. The VHE light curve reveals several high-amplitude and short-duration flares. Day-to-day flux variability is clearly pr esent (> 5σ). The photon index between 120 GeV and 8 TeV remains at the value ∼ 2.0 during both low and high flux states. The VHE spectral shape d oes not show significant variability, whereas the flux at 1 TeV change s by a factor of∼ 7. Fermi-LAT detected only eightγ-ray events in the energy range 10 GeV‐500 GeV in three years of observation. The measured photon index of = 1.3± 0.5 in the Fermi-LAT range is very hard. The X-ray measurements show strong variability in both flux and photon index. The latter varied from 1.76± 0.07 to 2.55± 0.07. Conclusions. The rapid variability measured inγ-rays and X-rays confirms the blazar-like behavior of IC 310. The multi-TeVγ-ray emission seems to originate from scales of less than 80 Schwarzschild radii (for a black hole mass of 2× 10 8 M⊙) within the compact core of its FR I radio jet with orientation angle 10 ◦ − 38 ◦ . The spectral energy distribution resembles that of an extr eme blazar, albeit the luminosity is more than two