Institution
University of Rijeka
Education•Rijeka, Croatia•
About: University of Rijeka is a education organization based out in Rijeka, Croatia. It is known for research contribution in the topics: Population & Tourism. The organization has 3471 authors who have published 7993 publications receiving 110386 citations. The organization is also known as: Rijeka University & Sveučilište u Rijeci.
Topics: Population, Tourism, European union, Immune system, Cytotoxic T cell
Papers published on a yearly basis
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TL;DR: The observed effects are obviously linked to the kindling phenomenon and not to seizure activity, and changes appeared mainly in the frontal cortex and hippocampus, i.e. brain areas believed to be directly involved in kindling.
56 citations
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Las Cumbres Observatory Global Telescope Network1, Chungbuk National University2, Queen Mary University of London3, Nagoya University4, University of St Andrews5, Ohio State University6, Osaka University7, Massey University8, Institut d'Astrophysique de Paris9, University of Arizona10, University of Warsaw11, Max Planck Society12, Royal Society13, European Southern Observatory14, Liverpool John Moores University15, Qatar Foundation16, University of Notre Dame17, University of Auckland18, Victoria University of Wellington19, Konan University20, College of Industrial Technology21, University of Concepción22, University of Toulouse23, Princeton University24, Korea Astronomy and Space Science Institute25, Heidelberg University26, Texas A&M University27, Tel Aviv University28, University of Valencia29, University of Canterbury30, University of Tasmania31, University of Rijeka32, University of Vienna33, NASA Exoplanet Science Institute34, Centre national de la recherche scientifique35, Space Telescope Science Institute36, University of Salerno37, Ames Research Center38, University of Göttingen39, University of Copenhagen40, Geological Museum41, University of Manchester42, Sharif University of Technology43, Keele University44
TL;DR: In this article, an analysis of the anomalous microlensing event, MOA-2010-BLG-073, announced by the Microlensing Observations in Astrophysics survey on 2010 March 18, is presented.
Abstract: We present an analysis of the anomalous microlensing event, MOA-2010-BLG-073, announced by the Microlensing Observations in Astrophysics survey on 2010 March 18. This event was remarkable because the source was previously known to be photometrically variable. Analyzing the pre-event source light curve, we demonstrate that it is an irregular variable over timescales >200 days. Its dereddened color, (V – I)_(S,0), is 1.221 ± 0.051 mag, and from our lens model we derive a source radius of 14.7 ± 1.3 R_☉, suggesting that it is a red giant star. We initially explored a number of purely microlensing models for the event but found a residual gradient in the data taken prior to and after the event. This is likely to be due to the variability of the source rather than part of the lensing event, so we incorporated a slope parameter in our model in order to derive the true parameters of the lensing system. We find that the lensing system has a mass ratio of q = 0.0654 ± 0.0006. The Einstein crossing time of the event, t_E = 44.3 ± 0.1 days, was sufficiently long that the light curve exhibited parallax effects. In addition, the source trajectory relative to the large caustic structure allowed the orbital motion of the lens system to be detected. Combining the parallax with the Einstein radius, we were able to derive the distance to the lens, D_L = 2.8 ± 0.4 kpc, and the masses of the lensing objects. The primary of the lens is an M-dwarf with M_(L,1) = 0.16 ± 0.03 M_☉, while the companion has M_(L,2) = 11.0 ± 2.0 M_J, putting it in the boundary zone between planets and brown dwarfs.
56 citations
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TL;DR: This work discovered that Nectin4 is a novel ligand for TIGIT and demonstrated that specific antibodies against it enhance tumor cell killing in vitro and in vivo.
Abstract: Background The use of checkpoint inhibitors has revolutionized cancer therapy. Unfortunately, these therapies often cause immune-related adverse effects, largely due to a lack of tumor specificity.
Methods We stained human natural killer cells using fusion proteins composed of the extracellular portion of various tumor markers fused to the Fc portion of human IgG1, and identified Nectin4 as a novel TIGIT ligand. Next, we generated a novel Nectin4 blocking antibody and demonstrated its efficacy as a checkpoint inhibitor in killing assays and in vivo.
Results We identify Nectin4 to be a novel ligand of TIGIT. We showed that, as opposed to all other known TIGIT ligands, which bind also additional receptors, Nectin4 interacts only with TIGIT. We show that the TIGIT-Nectin4 interaction inhibits natural killer cell activity, a critical part of the innate immune response. Finally, we developed blocking Nectin4 antibodies and demonstrated that they enhance tumor killing in vitro and in vivo.
Conclusion We discovered that Nectin4 is a novel ligand for TIGIT and demonstrated that specific antibodies against it enhance tumor cell killing in vitro and in vivo. Since Nectin4 is expressed almost exclusively on tumor cells, our Nectin4-blocking antibodies represent a combination of cancer specificity and immune checkpoint activity, which may prove more effective and safe for cancer immunotherapy.
56 citations
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TL;DR: In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy as mentioned in this paper, and the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository were presented.
Abstract: In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded.
56 citations
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TL;DR: Pattern recognition analysis applied on data on phenolic compounds content confirmed that quercetin, naringenin, caffeoylquinic acid, hydroxyphenylacetic acid, apigenin and genistein, could be considered as potential markers of botanical origin of honeydew honey.
56 citations
Authors
Showing all 3537 results
Name | H-index | Papers | Citations |
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Igor Rudan | 142 | 658 | 103659 |
Nikola Godinovic | 138 | 1469 | 100018 |
Ivica Puljak | 134 | 1436 | 97548 |
Damir Lelas | 133 | 1354 | 93354 |
D. Mekterovic | 110 | 449 | 46779 |
Ulrich H. Koszinowski | 96 | 281 | 27709 |
Michele Doro | 79 | 437 | 20090 |
Robert Zivadinov | 73 | 522 | 18636 |
D. Dominis Prester | 70 | 363 | 16701 |
Daniel Ferenc | 70 | 225 | 16145 |
Vladimir Parpura | 64 | 226 | 18050 |
Stipan Jonjić | 62 | 227 | 19363 |
Dario Hrupec | 60 | 288 | 13345 |
Alessandro Laviano | 59 | 298 | 14609 |
Tomislav Terzić | 58 | 271 | 10699 |