Institution
University of Rochester
Education•Rochester, New York, United States•
About: University of Rochester is a education organization based out in Rochester, New York, United States. It is known for research contribution in the topics: Population & Laser. The organization has 63915 authors who have published 112762 publications receiving 5484122 citations. The organization is also known as: Rochester University.
Topics: Population, Laser, Poison control, Health care, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: Results point to a critical role for B cells in regulating alloimmunity and provide a candidate set of genes for wider-scale screening of renal transplant recipients.
Abstract: Establishing long-term allograft acceptance without the requirement for continuous immunosuppression, a condition known as allograft tolerance, is a highly desirable therapeutic goal in solid organ transplantation. Determining which recipients would benefit from withdrawal or minimization of immunosuppression would be greatly facilitated by biomarkers predictive of tolerance. In this study, we identified the largest reported cohort to our knowledge of tolerant renal transplant recipients, as defined by stable graft function and receiving no immunosuppression for more than 1 year, and compared their gene expression profiles and peripheral blood lymphocyte subsets with those of subjects with stable graft function who are receiving immunosuppressive drugs as well as healthy controls. In addition to being associated with clinical and phenotypic parameters, renal allograft tolerance was strongly associated with a B cell signature using several assays. Tolerant subjects showed increased expression of multiple B cell differentiation genes, and a set of just 3 of these genes distinguished tolerant from nontolerant recipients in a unique test set of samples. This B cell signature was associated with upregulation of CD20 mRNA in urine sediment cells and elevated numbers of peripheral blood naive and transitional B cells in tolerant participants compared with those receiving immunosuppression. These results point to a critical role for B cells in regulating alloimmunity and provide a candidate set of genes for wider-scale screening of renal transplant recipients.
635 citations
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TL;DR: This survey reviews the approaches developed to reproduce various mobility patterns, with the main focus on recent developments, and organizes the subject by differentiating between individual and population mobility and also between short-range and long-range mobility.
635 citations
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University of Massachusetts Amherst1, University of Toledo2, Miami University3, Food and Drug Administration4, Yale University5, University of Louisville6, University of Western Ontario7, Taipei Medical University8, University of Rochester9, University of South Florida10, Eli Lilly and Company11, United States Department of Agriculture12, University of Düsseldorf13, Harvard University14, College of the Holy Cross15, University of Colorado Boulder16, Michigan State University17, Indiana University18, Jilin University19, University of Texas Health Science Center at San Antonio20, University of Louisiana at Monroe21, McMaster University22, RTI International23, University of Florida24, Kansas State University25, University of California, Irvine26, University of Michigan27, Aarhus University28, North Carolina State University29, Stanford University30, Lovelace Respiratory Research Institute31, University of Wyoming32, University of Tasmania33, Binghamton University34, New York Medical College35, National Institutes of Health36
TL;DR: This article offers a set of recommendations that scientists believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
635 citations
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TL;DR: New evidence indicates that the Gβγ dimer also plays a major part in signal transmission, enhancing the complexity of the possible interactions between the G proteins and their targets.
Abstract: When a membrane-bound receptor acts on a G protein, the GTP-binding or Gα subunit dissociates from the Gβγ dimer. Until recently, the Gα subunit alone was thought to act on the enzymes and ion channels controlled by these proteins. Newer evidence indicates that the Gβγ. dimer also plays a major part in signal transmission, enhancing the complexity of the possible interactions between the G proteins and their targets.
635 citations
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TL;DR: Why human learners display strong differences in learning differing types of non-adjacent regularities is discussed, and it is suggested that these contrasts in learnability may account for why human languages display non-approximate regularities of one type much more widely than non- adjacentregularities of the other type.
633 citations
Authors
Showing all 64186 results
Name | H-index | Papers | Citations |
---|---|---|---|
Eugene Braunwald | 230 | 1711 | 264576 |
Cyrus Cooper | 204 | 1869 | 206782 |
Eric J. Topol | 193 | 1373 | 151025 |
Dennis W. Dickson | 191 | 1243 | 148488 |
Scott M. Grundy | 187 | 841 | 231821 |
John C. Morris | 183 | 1441 | 168413 |
Ronald C. Petersen | 178 | 1091 | 153067 |
David R. Williams | 178 | 2034 | 138789 |
John Hardy | 177 | 1178 | 171694 |
Russel J. Reiter | 169 | 1646 | 121010 |
Michael Snyder | 169 | 840 | 130225 |
Jiawei Han | 168 | 1233 | 143427 |
Gang Chen | 167 | 3372 | 149819 |
Marc A. Pfeffer | 166 | 765 | 133043 |
Salvador Moncada | 164 | 495 | 138030 |