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Institution

University of Rochester

EducationRochester, New York, United States
About: University of Rochester is a education organization based out in Rochester, New York, United States. It is known for research contribution in the topics: Population & Laser. The organization has 63915 authors who have published 112762 publications receiving 5484122 citations. The organization is also known as: Rochester University.


Papers
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Journal ArticleDOI
12 Jul 2002-Science
TL;DR: It is shown that PARP-1 activation is required for translocation of apoptosis-inducing factor (AIF) from the mitochondria to the nucleus and that AIF is necessary for PARp-1–dependent cell death.
Abstract: Poly(ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA damage surveillance network. PARP-1 is also a mediator of cell death after ischemia-reperfusion injury, glutamate excitotoxicity, and various inflammatory processes. We show that PARP-1 activation is required for translocation of apoptosis-inducing factor (AIF) from the mitochondria to the nucleus and that AIF is necessary for PARP-1–dependent cell death. N -methyl- N ′-nitro- N -nitrosoguanidine, H2O2, and N -methyl-d-aspartate induce AIF translocation and cell death, which is prevented by PARP inhibitors or genetic knockout of PARP-1, but is caspase independent. Microinjection of an antibody to AIF protects against PARP-1–dependent cytotoxicity. These data support a model in which PARP-1 activation signals AIF release from mitochondria, resulting in a caspase-independent pathway of programmed cell death.

1,781 citations

Journal ArticleDOI
TL;DR: Clinicians and patients should maximize the therapeutic effects of communication by explicitly orienting communication to achieve intermediate outcomes associated with improved health.

1,780 citations

Journal ArticleDOI
TL;DR: In this paper, the authors tested a self-determination theory based model in which employees' autonomous causality orientation and their perceptions of their managers' autonomy support independently predicted satisfaction of the employees' intrinsic needs for competence, autonomy, and relatedness, which in turn predicted their performance evaluations and psychological adjustment.
Abstract: Studies in 2 work organizations tested a self-determination theory based model in which employees’ autonomous causality orientation and their perceptions of their managers’ autonomy support independently predicted satisfaction of the employees’ intrinsic needs for competence, autonomy, and relatedness, which in turn predicted their performance evaluations and psychological adjustment. Path analysis indicated that the self-determination theory model fit the data very well and that alternative models did not provide any advantage.

1,769 citations

Journal ArticleDOI
TL;DR: In this article, the authors predict and document evidence that the earnings response coefficient is a function of riskless interest rates and the riskiness, growth and/or persistence of earnings.

1,769 citations


Authors

Showing all 64186 results

NameH-indexPapersCitations
Eugene Braunwald2301711264576
Cyrus Cooper2041869206782
Eric J. Topol1931373151025
Dennis W. Dickson1911243148488
Scott M. Grundy187841231821
John C. Morris1831441168413
Ronald C. Petersen1781091153067
David R. Williams1782034138789
John Hardy1771178171694
Russel J. Reiter1691646121010
Michael Snyder169840130225
Jiawei Han1681233143427
Gang Chen1673372149819
Marc A. Pfeffer166765133043
Salvador Moncada164495138030
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023101
2022383
20213,841
20203,895
20193,699
20183,541