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Institution

University of Rostock

EducationRostock, Germany
About: University of Rostock is a education organization based out in Rostock, Germany. It is known for research contribution in the topics: Catalysis & Population. The organization has 14216 authors who have published 32296 publications receiving 755196 citations. The organization is also known as: Rostock University.


Papers
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Journal ArticleDOI
09 Oct 2014-Nature
TL;DR: The results suggest that, in addition to mitigating primary particulate emissions, reducing the emissions of secondary aerosol precursors from fossil fuel combustion and biomass burning is likely to be important for controlling China’s PM2.5 levels and for reducing the environmental, economic and health impacts resulting from particulate pollution.
Abstract: Rapid industrialization and urbanization in developing countries has led to an increase in air pollution, along a similar trajectory to that previously experienced by the developed nations. In China, particulate pollution is a serious environmental problem that is influencing air quality, regional and global climates, and human health. In response to the extremely severe and persistent haze pollution experienced by about 800 million people during the first quarter of 2013 (refs 4, 5), the Chinese State Council announced its aim to reduce concentrations of PM2.5 (particulate matter with an aerodynamic diameter less than 2.5 micrometres) by up to 25 per cent relative to 2012 levels by 2017 (ref. 6). Such efforts however require elucidation of the factors governing the abundance and composition of PM2.5, which remain poorly constrained in China. Here we combine a comprehensive set of novel and state-of-the-art offline analytical approaches and statistical techniques to investigate the chemical nature and sources of particulate matter at urban locations in Beijing, Shanghai, Guangzhou and Xi'an during January 2013. We find that the severe haze pollution event was driven to a large extent by secondary aerosol formation, which contributed 30-77 per cent and 44-71 per cent (average for all four cities) of PM2.5 and of organic aerosol, respectively. On average, the contribution of secondary organic aerosol (SOA) and secondary inorganic aerosol (SIA) are found to be of similar importance (SOA/SIA ratios range from 0.6 to 1.4). Our results suggest that, in addition to mitigating primary particulate emissions, reducing the emissions of secondary aerosol precursors from, for example, fossil fuel combustion and biomass burning is likely to be important for controlling China's PM2.5 levels and for reducing the environmental, economic and health impacts resulting from particulate pollution.

3,372 citations

Journal ArticleDOI
TL;DR: Research suggests that ageing processes are modifiable and that people are living longer without severe disability, and this finding will be important for the chances to meet the challenges of ageing populations.

3,095 citations

Book
01 Jan 1987
TL;DR: The Strong Perfect Graph Conjecture as discussed by the authors is based on the strong perfect graph conjecture, which is a generalization of the concept of generalized perfection, generalized perfection and related concepts.
Abstract: Preface 1. Basic Concepts 2. Perfection, Generalized Perfection, and Related Concepts 3. Cycles, Chords and Bridges 4. Models and Interactions 5. Vertex and Edge Orderings 6. Posets 7. Forbidden Subgraphs 8. Hypergraphs and Graphs 9. Matrices and Polyhedra 10. Distance Properties 11. Algebraic Compositions and Recursive Definitions 12. Decompositions and Cutsets 13. Threshold Graphs and Related Concepts 14. The Strong Perfect Graph Conjecture Appendix A. Recognition Appendix B. Containment Relationships Bibliography Index.

1,958 citations

Journal ArticleDOI
TL;DR: Data collected demonstrate that there is a strong association between GBA mutations and Parkinson's disease, and those with a GBA mutation presented earlier with the disease, were more likely to have affected relatives, and were morelikely to have atypical clinical manifestations.
Abstract: Background Recent studies indicate an increased frequency of mutations in the gene encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among patients with Parkinson's disease. We aimed to ascertain the frequency of GBA mutations in an ethnically diverse group of patients with Parkinson's disease. Methods Sixteen centers participated in our international, collaborative study: five from the Americas, six from Europe, two from Israel, and three from Asia. Each center genotyped a standard DNA panel to permit comparison of the genotyping results across centers. Genotypes and phenotypic data from a total of 5691 patients with Parkinson's disease (780 Ashkenazi Jews) and 4898 controls (387 Ashkenazi Jews) were analyzed, with multivariate logistic-regression models and the Mantel–Haenszel procedure used to estimate odds ratios across centers. Results All 16 centers could detect two GBA mutations, L444P and N370S. Among Ashkenazi Jewish subjects, either mutation was found in 15% of p...

1,629 citations

Journal ArticleDOI
Julie George1, Jing Shan Lim2, Se Jin Jang3, Yupeng Cun1, Luka Ozretić, Gu Kong4, Frauke Leenders1, Xin Lu1, Lynnette Fernandez-Cuesta1, Graziella Bosco1, Christian Müller1, Ilona Dahmen1, Nadine Jahchan2, Kwon-Sik Park2, Dian Yang2, Anthony N. Karnezis5, Dedeepya Vaka2, Ángela Torres2, Maia Segura Wang, Jan O. Korbel, Roopika Menon6, Sung-Min Chun3, Deokhoon Kim3, Matthew D. Wilkerson7, Neil Hayes7, David Engelmann8, Brigitte M. Pützer8, Marc Bos1, Sebastian Michels6, Ignacija Vlasic, Danila Seidel1, Berit Pinther1, Philipp Schaub1, Christian Becker1, Janine Altmüller1, Jun Yokota9, Takashi Kohno, Reika Iwakawa, Koji Tsuta, Masayuki Noguchi10, Thomas Muley11, Hans Hoffmann11, Philipp A. Schnabel12, Iver Petersen13, Yuan Chen13, Alex Soltermann14, Verena Tischler14, Chang-Min Choi3, Yong-Hee Kim3, Pierre P. Massion15, Yong Zou15, Dragana Jovanovic16, Milica Kontic16, Gavin M. Wright17, Prudence A. Russell17, Benjamin Solomon17, Ina Koch, Michael Lindner, Lucia Anna Muscarella18, Annamaria la Torre18, John K. Field19, Marko Jakopović20, Jelena Knezevic, Esmeralda Castaños-Vélez21, Luca Roz, Ugo Pastorino, O.T. Brustugun22, Marius Lund-Iversen22, Erik Thunnissen23, Jens Köhler, Martin Schuler, Johan Botling24, Martin Sandelin24, Montserrat Sanchez-Cespedes, Helga B. Salvesen25, Viktor Achter1, Ulrich Lang1, Magdalena Bogus1, Peter M. Schneider1, Thomas Zander, Sascha Ansén6, Michael Hallek1, Jürgen Wolf6, Martin Vingron26, Yasushi Yatabe, William D. Travis27, Peter Nürnberg1, Christian Reinhardt, Sven Perner3, Lukas C. Heukamp, Reinhard Büttner, Stefan A. Haas26, Elisabeth Brambilla28, Martin Peifer1, Julien Sage2, Roman K. Thomas1 
06 Aug 2015-Nature
TL;DR: This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.
Abstract: We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation. Thus, loss of the tumour suppressors TP53 and RB1 is obligatory in SCLC. We discovered somatic genomic rearrangements of TP73 that create an oncogenic version of this gene, TP73Δex2/3. In rare cases, SCLC tumours exhibited kinase gene mutations, providing a possible therapeutic opportunity for individual patients. Finally, we observed inactivating mutations in NOTCH family genes in 25% of human SCLC. Accordingly, activation of Notch signalling in a pre-clinical SCLC mouse model strikingly reduced the number of tumours and extended the survival of the mutant mice. Furthermore, neuroendocrine gene expression was abrogated by Notch activity in SCLC cells. This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer.

1,504 citations


Authors

Showing all 14396 results

NameH-indexPapersCitations
Tim Adye1431898109010
Paul Jackson141137293464
Carl-Henrik Heldin13152067528
Wolfgang Lohmann131148888358
Marc Escalier129106783546
Virginia Azzolini128115379298
Stephen M. Stahl115147761371
Gereon R. Fink11486760853
Matthias Beller11373346344
Harald Hampel10960165160
Sebastian Bachmann105111950944
Roland Waldi99118049943
Paul Knochel99237344786
Javier Pérez-Ramírez9754034165
Matthias Beller9790334480
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202395
2022245
20211,790
20201,724
20191,697
20181,636