Showing papers by "University of Salford published in 2004"

Learning Styles: An overview of theories, models, and measures

Abstract: Although its origins have been traced back much further, research in the area of learning style has been active for—at a conservative estimate—around four decades. During that period the intensity of activity has varied, with recent years seeing a particularly marked upturn in the number of researchers working in the area. Also of note is the variety of disciplines from which the research is emerging. Increasingly, research in the area of learning style is being conducted in domains outside psychology—the discipline from which many of the central concepts and theories originate. These domains include medical and health care training, management, industry, vocational training and a vast range of settings and levels in the field of education. It is of little wonder that applications of these concepts are so wide ranging given the centrality of learning—and how best to do it—to almost every aspect of life. As a consequence of the quantity of research, the diversity of the disciplines and domains in which the...

Reciprocity in optics

Abstract: The application of reciprocity principles in optics has a long history that goes back to Stokes, Lorentz, Helmholtz and others. Moreover, optical applications need to be seen in the context of applications of reciprocity in particle scattering, acoustics, seismology and the solution of inverse problems, generally. In some of these other fields vector wave propagation is, as it is in optics, of the essence. For this reason the simplified approach to light wave polarization developed by, and named for, Jones is explored initially to see how and to what extent it encompasses reciprocity. The characteristic matrix of a uniform dielectric layer, used in the analysis of interference filters and mirrors, is reciprocal except when the layer is magneto-optical. The way in which the reciprocal nature of a characteristic matrix can be recognized is discussed next. After this, work on the influence of more realistic attributes of a dielectric stack on reciprocity is reviewed. Some of the numerous technological applications of magneto-optic non-reciprocal media are identified and the potential of a new class of non-reciprocal components is briefly introduced. Finally, the extension of the classical reciprocity concept to systems containing components that have nonlinear optical response is briefly mentioned.

Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management.

Abstract: Hyperprolactinaemia is an important but neglected adverse effect of antipsychotic medication. It occurs frequently with conventional antipsychotics and some atypical antipsychotics (risperidone and amisulpride) but is rare with other atypical antipsychotics (aripiprazole, clozapine, olanzapine, quetiapine, ziprasidone). For this reason the terms 'prolactin-sparing' and 'prolactin-raising' are more useful than 'atypical' and 'conventional' when considering the effect of antipsychotic drugs on serum prolactin. During antipsychotic treatment prolactin levels can rise 10-fold or more above pretreatment values. In a recent study approximately 60% of women and 40% of men treated with a prolactin-raising antipsychotic had a prolactin level above the upper limit of the normal range. The distinction between asymptomatic and symptomatic hyperprolactinaemia is important but is often not made in the literature. Some symptoms of hyperprolactinaemia result from a direct effect of prolactin on target tissues but others result from hypogonadism caused by prolactin disrupting the normal functioning of the hypothalamic-pituitary-gonadal axis. Symptoms of hyperprolactinaemia include gynaecomastia, galactorrhoea, sexual dysfunction, infertility, oligomenorrhoea and amenorrhoea. These symptoms are little researched in psychiatric patients. Existing data suggest that they are common but that clinicians underestimate their prevalence. For example, well conducted studies of women treated with conventional antipsychotics have reported prevalence rates of approximately 45% for oligomenorrhoea/amenorrhoea and 19% for galactorrhoea. An illness-related under-function of the hypothalamic-pituitary-gonadal axis in female patients with schizophrenia may also contribute to menstrual irregularities. Long-term consequences of antipsychotic-related hypogonadism require further research but are likely and include premature bone loss in men and women. There are conflicting data on whether hyperprolactinaemia is associated with an increased risk of breast cancer in women. In patients prescribed antipsychotics who have biochemically confirmed hyperprolactinaemia it is important to exclude other causes of prolactin elevation, in particular tumours in the hypothalamic-pituitary area. If a patient has been amenorrhoeic for 1 year or more, investigations should include bone mineral density measurements. Management should be tailored to the individual patient. Options include reducing the dose of the antipsychotic, switching to a prolactin-sparing agent, prescribing a dopamine receptor agonist and prescribing estrogen replacement in hypoestrogenic female patients. The efficacy and risks of the last two treatment options have not been systematically examined. Antipsychotic-induced hyperprolactinaemia should become a focus of interest in the drug treatment of psychiatric patients, particularly given the recent introduction of prolactin-sparing antipsychotics. Appropriate investigations and effective management should reduce the burden of adverse effects and prevent long-term consequences.

Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

Abstract: In table 3, the correlation coefficient between peak plasma cortisol and mRS at 3 months (column 4, row 5), should read 0.48, not 0. [1].

Long-term safety and efficacy of enzyme replacement therapy for Fabry disease.

Abstract: Elsewhere, we reported the safety and efficacy results of a multicenter phase 3 trial of recombinant human α-galactosidase A (rh-αGalA) replacement in patients with Fabry disease. All 58 patients who were enrolled in the 20-wk phase 3 double-blind, randomized, and placebo-controlled study received subsequently 1 mg/kg of rh-αGalA (agalsidase beta, Fabrazyme, Genzyme Corporation) biweekly in an ongoing open-label extension study. Evidence of long-term efficacy, even in patients who developed IgG antibodies against rh-αGalA, included the continuously normal mean plasma globotriaosylceramide (GL-3) levels during 30 mo of the extension study and the sustained capillary endothelial GL-3 clearance in 98% (39/40) of patients who had a skin biopsy taken after treatment for 30 mo (original placebo group) or 36 mo (original enzyme-treated group). The mean serum creatinine level and estimated glomerular filtration rate also remained stable after 30–36 mo of treatment. Infusion-associated reactions decreased over time, as did anti-rh-αGalA IgG antibody titers. Among seroconverted patients, after 30–36 mo of treatment, seven patients tolerized (no detectable IgG antibody), and 59% had ⩾4-fold reductions in antibody titers. As of 30 mo into the extension trial, three patients were withdrawn from the study because of positive serum IgE or skin tests; however, all have been rechallenged successfully at the time of this report. Thus, enzyme replacement therapy for 30–36 mo with agalsidase beta resulted in continuously decreased plasma GL-3 levels, sustained endothelial GL-3 clearance, stable kidney function, and a favorable safety profile.

Knowledge of famous faces and names in semantic dementia.

Abstract: Semantic dementia is a focal clinical syndrome, resulting from degeneration of the temporal lobes and characterized by progressive loss of conceptual knowledge about the world. Because of the highly circumscribed nature of the disorder it is a natural model for improving understanding of how semantic information is cerebrally represented. There is currently a lack of consensus. One view proposes the existence of modality specific meaning systems, in which visual and verbal information are stored separately. An opposing view assumes that information is represented by a unitary, amodal semantic system. The present study explores these alternatives in an examination of famous face and name knowledge in 15 patients with semantic dementia. The study of face recognition in patients with an established semantic disorder also permits an examination of the relationship between semantic dementia and the focal clinical syndrome of progressive prosopagnosia. The semantic dementia patients were profoundly impaired on both face and name identification and familiarity judgement tasks compared with amnesic patients with Alzheimer's disease and healthy controls. However, whereas the two reference groups performed better for names than faces, the semantic group showed the opposite pattern. This overall profile masked individual differences: semantic dementia patients with predominant left temporal lobe atrophy showed better recognition of names than faces, whereas patients with right temporal predominance showed the reverse pattern. Relative superiority for names or faces was mirrored by corresponding superiority for words or pictures on a standard semantic test. We interpret the findings as inconsistent with a unitary, amodal model of semantic memory. However, the data are not wholly compatible with a strict multiple system account. The data favour a model of semantic memory comprising a single interconnected network, with dedicated brain regions representing modality specific information. The data emphasize the importance of the anterior, inferolateral parts of the left temporal lobe for the representation of names and the corresponding parts of the right temporal lobe for faces. Dissociations between face and name knowledge provide a challenge for existing models of face processing. Moreover, they lead us to argue that the focal syndrome of progressive prosopagnosia is one of the clinical presentations of semantic dementia and not a separate clinical entity.

Nonlinear surface waves in left-handed materials.

Abstract: We study both linear and nonlinear surface waves localized at the interface separating a left-handed (LH) medium (i.e., a medium with both negative dielectric permittivity and negative magnetic permeability) and a conventional [or right-handed (RH)] dielectric medium. We demonstrate that the interface can support both TE- and TM-polarized surface waves-surface polaritons, and we study their properties. We describe the intensity-dependent properties of nonlinear surface waves in three different cases, i.e., when both the LH and RH media are nonlinear and when either of the media is nonlinear. In the case when both media are nonlinear, we find two types of nonlinear surface waves, one with the maximum amplitude at the interface, and the other one with two humps. In the case when one medium is nonlinear, only one type of surface wave exists, which has the maximum electric field at the interface, unlike waves in right-handed materials where the surface-wave maximum is usually shifted into a self-focusing nonlinear medium. We discuss the possibility of tuning the wave group velocity in both the linear and nonlinear cases, and show that group-velocity dispersion, which leads to pulse broadening, can be balanced by the nonlinearity of the media, so resulting in soliton propagation.

How can SMEs effectively implement the CSR agenda? A UK case study perspective

Abstract: This paper focuses on implementation of the CSR agenda in small-to-medium enterprises (SMEs) and reports on research findings from an action research case study that has been conducted in a UK based SME. The case study research demonstrates how the CSR agenda has been implemented using ISO 9001:2000 as a platform and what benefits the case study organization has gained from this approach. These results are compared with a UK survey on feasibility of CSR for SMEs conducted by the UK's Department of Trade and Industry and parallels are drawn. Copyright © 2004 John Wiley & Sons, Ltd and ERP Environment.

Consumer value conflicts surrounding ethical food purchase decisions: a focus on animal welfare

Abstract: Ethical attitudes in relation to meat purchases were studied among urban and rural consumers in Scotland. All subjects perceived at least some ethical issues in relation to animal production systems, in particular, systems keeping animals in close confinement. Welfare-friendly production systems were viewed as adding value to a food, but this value was not necessarily realizable to producers if purchases occurred only when foods were on special offer. Statements made by individuals were often contradictory, revealing ambivalence, unresolved value conflicts and a general lack of involvement in the nature of meat production. A number of barriers to the establishment of stable attitudes and behaviours in relation to the ethical treatment of food animals were also identified. A key finding of the study is that individuals can hold two views on animal welfare. On the one hand, they may think as citizens influencing societal standards, and on the other, as consumers at the point of purchase. As citizens, they support the notion of animals being entitled to a good life; as meat consumers, they avoid the cognitive connection with the live animal. This paper explores both the citizen‐consumer relationship and purchase strategies used by consumers to resolve value conflicts. Lessons for public and commercial policy are highlighted in the context of the Curry Report (2002) which advocates more effective market segmentation where markets are finely attuned to their customers, with the development of a number of assurance schemes discussed in the article.

Measurement of catecholamines and their metabolites.

Abstract: Analysis of the low levels of catecholamines and metabolites in tissue and biological fluids has necessitated the use of highly sensitive analytical techniques. Earlier procedures utilizing radioenzymatic and immunological assays, gas chromatography or fluorimetry have generally been superseded by highly sensitive and selective chromatographic methods utilizing electrochemical or fluorimetric detection. The development of high-performance liquid chromatography (HPLC) methods for the measurement of plasma metadrenalines and the combination of HPLC with tandem mass spectrometry provides additional procedures with minimum interference from drugs and drug metabolites. This review summarizes the methodology currently available for the measurement of catecholamines and metabolites in plasma and urine, the influence of sample collection protocols and the clinical application of the methods for the biochemical detection of catecholamine-secreting tumours.

DNA differential diagnosis of taeniasis and cysticercosis by multiplex PCR

Abstract: Multiplex PCR was established for differential diagnosis of taeniasis and cysticercosis, including their causative agents. For identification of the parasites, multiplex PCR with cytochrome c oxidase subunit 1 gene yielded evident differential products unique for Taenia saginata and Taenia asiatica and for American/African and Asian genotypes of Taenia solium with molecular sizes of 827, 269, 720, and 984 bp, respectively. In the PCR-based detection of tapeworm carriers using fecal samples, the diagnostic markers were detected from 7 of 14 and 4 of 9 T. solium carriers from Guatemala and Indonesia, respectively. Test sensitivity may have been reduced by the length of time (up to 12 years) that samples were stored and/or small sample volumes (ca. 30 to 50 mg). However, the diagnostic markers were detected by nested PCR in five worm carriers from Guatemalan cases that were found to be negative by multiplex PCR. It was noteworthy that a 720 bp-diagnostic marker was detected from a T. solium carrier who was egg-free, implying that it is possible to detect worm carriers and treat before mature gravid proglottids are discharged. In contrast to T. solium carriers, 827-bp markers were detected by multiplex PCR in all T. saginata carriers. The application of the multiplex PCR would be useful not only for surveillance of taeniasis and cysticercosis control but also for the molecular epidemiological survey of these cestode infections.

Reflections on the use of blended learning

Abstract: This paper reflects upon the experience of the delivery of a program at the University of Salford using blended learning. Facilitated by action research, it reports on the lessons learnt since the paper by Procter “Blended Learning in Practice”(Procter, 2003). Within the first cycle of action research we captured staff and students’ opinions regarding the program, these are discussed in this paper. A number of lessons and conclusions are drawn, in particular, we argue for the need for theoretical underpinning and that Laurillard’s Conversational Framework (Laurillard, 1993)is a valuable tool for blended learning, leading us to test the theory in practice over the coming two years. One of the main findings is the importance of transparent communication on a blended learning course.

Abnormalities on magnetic resonance imaging seen acutely following mild traumatic brain injury: correlation with neuropsychological tests and delayed recovery

Abstract: Mild traumatic brain injury (MTBI) is a common reason for hospital attendance and is associated with significant delayed morbidity. We studied a series of 80 persons with MTBI. Magnetic resonance imaging (MRI) and neuropsychological testing were used in the acute phase and a questionnaire for post-concussion syndrome (PCS) and return to work status at 6 months. In 26 subjects abnormalities were seen on MRI, of which 5 were definitely traumatic. There was weak correlation with abnormal neuropsychological tests for attention in the acute period. There was no significant correlation with a questionnaire for PCS and return to work status. Although non-specific abnormalities are frequently seen, standard MRI techniques are not helpful in identifying patients with MTBI who are likely to have delayed recovery.

What can experience add to early medical education? Consensus survey

Abstract: Objective To provide a rationale for integrating experience into early medical education (“early experience”). Design Small group discussions to obtain stakeholders9 views. Grounded theory analysis with respondent, internal, and external validation. Setting Problem based, undergraduate medical curriculum that is not vertically integrated. Participants A purposive sample of 64 students, staff, and curriculum leaders from three university medical schools in the United Kingdom. Results Without early experience, the curriculum was socially isolating and divorced from clinical practice. The abruptness of students9 transition to the clinical environment in year 3 generated positive and negative emotions. The rationale for early experience would be to ease the transition; orientate the curriculum towards the social context of practice; make students more confident to approach patients; motivate them; increase their awareness of themselves and others; strengthen, deepen, and contextualise their theoretical knowledge; teach intellectual skills; strengthen learning of behavioural and social sciences; and teach them about the role of health professionals. Conclusion A rationale for early experience would be to strengthen and deepen cognitively, broaden affectively, contextualise, and integrate medical education. This is partly a process of professional socialisation that should start earlier to avoid an abrupt transition. “Experience” can be defined as “authentic human contact in a social or clinical context that enhances learning of health, illness or disease, and the role of the health professional.”

Caring for Agents and Agents that Care: Building Empathic Relations with Synthetic Agents

Abstract: When building agents and synthetic characters, and in order to achieve believability, we must consider the emotional relations established between users and characters, that is, we must consider the issue of "empathy". Defined in broad terms as "An observer reacting emotionally because he perceives that another is experiencing or about to experience an emotion", empathy is an important element to consider in the creation of relations between humans and agents. In this paper we will focus on the role of empathy in the construction of synthetic characters, providing some requirements for such construction and illustrating the presented concepts with a specific system called FearNot!. FearNot! was developed to address the difficult and often devastating problem of bullying in schools. By using role playing and empathic synthetic characters in a 3D environment, FearNot! allows children from 8 to 12 to experience a virtual scenario where they can witness (in a third-person perspective) bullying situations. To build empathy into FearNot! we have considered the following components: agentýs architecture; the charactersý embodiment and emotional expression; proximity with the user and emotionally charged situations.We will describe how these were implemented in FearNot! and report on the preliminary results we have with it.

Integrating corporate social responsibility (CSR) into ISO management systems – in search of a feasible CSR management system framework

Abstract: Following the growing interest in corporate governance and corporate social responsibility (CSR), the International Organization for Standardization (ISO) Committee on Consumer Policy (ISO/COPOLCO) opened the discussion about the feasibility of CSR management system standard. In this paper, we investigate the underlying issues that shape the development of CSR standard. Based on our case study research, we provide a framework for organisations to establish, manage, improve and document a CSR management system. This framework is based on process and systems thinking and analogous to ISO 9001:2000 adding significantly to existing definitive management frameworks. Finally, we outline areas for further research and indicate substantial managerial implications.

Producers and consumers of organic meat: A focus on attitudes and motivations

Abstract: Research into organic production is internationally widespread but has rarely focused on producer's motivations for adopting organic farming techniques and whether organic consumers share their values. As conventional agricultural prices remain depressed, questions arise surrounding producer's motivations towards organic production. For example, are motivations based on economic rather than ethical decisions? Additionally, what motivations underpin consumer's organic purchases and are those values shared between producers and consumers? Using postal questionnaires, the attitudes and motivations of both producers and consumers towards organic livestock production, are explored. Future recommendations are made to the industry with regard to the UK market for organically produced meat.

Patient-friendly hospital environments: exploring the patients' perspective.

Abstract: Objective To investigate the perceptions and attitudes of patients to the built environments of NHS Trust hospitals, in order to inform design excellence so as to make future hospitals places and spaces responsive to patient needs Design An exploratory study of patients perceptions based on qualitative semi-structured personal interviews Setting and participants Fifty one-to-one interviews held with hospital in-patients across the four directorates of surgery, medicine, care of the elderly and maternity at Salford Royal Hospitals NHS Trust, Salford, UK Results The research found that there was much similarity in the priorities, issues and concerns raised by patients in each of the four directorates Patients perceived the built environment of the hospital as a supportive environment Their accounts in each area pointed to the significance of the factors that immediately impacted on them and their families Patients identified having a need for personal space, a homely welcoming atmosphere, a supportive environment, good physical design, access to external areas and provision of facilities for recreation and leisure Responses suggest that patient attitudes and perceptions to the built environment of hospital facilities relates to whether the hospital provides a welcoming homely space for themselves and their visitors that promotes health and wellbeing Conclusions The findings have important implications for capital development teams, clinical staff, managers and NHS Estates personnel Although the study has immediate relevance for Salford Royal Hospitals Trust, findings and recommendations reported provide NHS Estates and other relevant stakeholders with evidence-based knowledge and understanding of patients’ perceptions and expectations of and preferences for particular facilities and estates provision in NHS hospitals