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Institution

University of Salford

EducationSalford, Manchester, United Kingdom
About: University of Salford is a education organization based out in Salford, Manchester, United Kingdom. It is known for research contribution in the topics: Population & Thin film. The organization has 13049 authors who have published 22957 publications receiving 537330 citations. The organization is also known as: University of Salford Manchester & The University of Salford Manchester.


Papers
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Journal ArticleDOI
TL;DR: Mechanisms by which Treg functions modulate the immune response to tumors are becoming further understood, however, specific markers to tumor-specific/induced Tregs are yet to be clearly identified, which is a major limitation in optimizing strategies to specifically target T Regs in cancer.
Abstract: Importance of the field: The active suppression of immune responses against tumor is a major barrier to the likely success of cancer immunotherapy. There is now compelling evidence implicating T regulatory cells (Tregs) as being key players driving immune suppression. Elevated frequencies of Tregs within the peripheral circulation and tumor microenvironment of cancer patients correlate with poor prognosis and reduced survival. Understanding the mechanism of Treg elevation is critical for the development of new approaches aiming to modulate the frequency and function of Tregs to enhance the efficacy of cancer immune-based therapies. Areas covered in this review: This review focuses on current knowledge concerning Tregs in cancer and discusses putative mechanisms which underlie the expansion of Tregs in cancer patients. Additionally, we review current strategies to deplete/suppress Treg activity, the limitations of these strategies and future perspective for improving their efficacy. What the reader will ga...

125 citations

Journal ArticleDOI
TL;DR: MRI of carotid plaque and embolic signals during transcranial Doppler have identified features beyond luminal stenosis that are predictive of future transient ischemic attacks and stroke.
Abstract: Carotid atherosclerotic plaques represent both stable and unstable atheromatous lesions. Atherosclerotic plaques that are prone to rupture owing to their intrinsic composition such as a large lipid core, thin fibrous cap and intraplaque hemorrhage are associated with subsequent thromboembolic ischemic events. At least 15–20% of all ischemic strokes are attributable to carotid artery atherosclerosis. Characterization of plaques may enhance the understanding of natural history and ultimately the treatment of atherosclerotic disease. MRI of carotid plaque and embolic signals during transcranial Doppler have identified features beyond luminal stenosis that are predictive of future transient ischemic attacks and stroke. The value of specific therapies to prevent stroke in symptomatic and asymptomatic patients with severe carotid artery stenosis are the subject of current research and analysis of recently published clinical trials that are discussed in this article.

125 citations

Journal ArticleDOI
TL;DR: The links between adipokine dysregulation and the development of hypertension and diabetes are discussed and the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity is explored.
Abstract: Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be the inflammatory cell population in adipose tissue. Healthy adipose tissue secretes a number of vasoactive adipokines and anti-inflammatory cytokines, and changes to this secretory profile will contribute to pathogenesis in obesity. In this review, we discuss the links between adipokine dysregulation and the development of hypertension and diabetes and explore the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity.

125 citations

Journal ArticleDOI
TL;DR: Differential thermal analysis (DTA) of 25 oxalates in an atmosphere of oxygen and nitrogen is reported in this paper, showing that in some cases in nitrogen the metal is formed, in other cases the oxide of lowest valency state is produced, while a third group give the same oxide product in nitrogen and oxygen.
Abstract: Differential thermal analysis (DTA) of some 25 oxalates are reported in atmospheres of oxygen and nitrogen. It is shown that in some cases in nitrogen the metal is formed, in other cases the oxide of lowest valency state is produced, while a third group give the same oxide product in nitrogen and oxygen. The production in oxygen of the oxide for the first group, and of a higher oxide in the second group is a phenomenon which in the first case involves a further reaction of the metal with the oxygen atmosphere. Another group of oxalates produce characteristic DTA curves due to the formation of carbonate as the initial decomposition product. The dehydrations of these oxalates are marked by endothermic peaks.

125 citations

Journal ArticleDOI
TL;DR: There are parent and child factors that need consideration when choosing an appropriate intervention programme for a child with language impairment and the Hanen Parent Programme was twice as intensive as clinic therapy based on average group size, which has resource implications.
Abstract: Background: Both direct (clinician to child) and indirect (clinician to carer) approaches are currently used in the management of children with language delay, but there is as yet little evidence about their relative effects or resource implications.Aims: This research project compared the Hanen Parent Programme (HPP) in terms of its effectiveness and consequent suitability for an inner‐city UK population with clinic‐based, direct intervention.Methods & Procedures: Thirty‐seven children aged 2;06–3;06 years with a diagnosis of language impairment and their parents took part in the research project. The children were allocated on a geographical basis to receive therapy either as part of an HPP or in a clinic. Nineteen children and their families took part in one of the five Hanen groups that ran successively over 16 months; 18 children and their families received clinic‐based intervention. The children's language was assessed using the PLS‐3 (UK version) and from an analysis of audio‐taped parent and child...

125 citations


Authors

Showing all 13134 results

NameH-indexPapersCitations
Hongjie Dai197570182579
Michael P. Lisanti15163185150
Matthew Jones125116196909
David W. Denning11373666604
Wayne Hall111126075606
Richard Gray10980878580
Christopher E.M. Griffiths10867147675
Thomas P. Davis10772441495
Nicholas Tarrier9232625881
David M. A. Mann8833843292
Ajith Abraham86111331834
Federica Sotgia8524728751
Mike Hulme8430035436
Robert N. Foley8426031580
Richard Baker8351422970
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202331
2022139
2021880
2020888
2019842
2018781