University of Salford

About: University of Salford is a education organization based out in Salford, Manchester, United Kingdom. It is known for research contribution in the topics: Population & Thin film. The organization has 13049 authors who have published 22957 publications receiving 537330 citations. The organization is also known as: University of Salford Manchester & The University of Salford Manchester.

Influence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles

Abstract: The transport and the delivery of drugs through nanocarriers is a great challenge of pharmacology Since the production of liposomes to reduce the toxicity of doxorubicin in patients, a plethora of nanomaterials have been produced and characterized Although it is widely known that elementary properties of nanomaterials influence their in vivo kinetics, such interaction is often poorly investigated in many preclinical studies The present study aims to evaluate the actual effect of size and shape on the biodistribution of a set of gold nanoparticles (GNPs) after intravenous administration in mice To this goal, quantitative data achieved by inductively coupled plasma mass spectrometry and observational results emerging from histochemistry (autometallography and enhanced dark-field hyperspectral microscopy) were combined Since the immune system plays a role in bionano-interaction we used healthy immune-competent mice To keep the immune surveillance on the physiological levels we synthesized endotoxin-fre

Need for Alternative Research Approaches in Construction Management: Case of Delay Studies

Abstract: Over the years, there have been many studies of delay in construction, and this type of study continues to be popular in construction management research. A synthesis and critical evaluation of delay studies in developing countries reveals that poor project management is cited as one of the main causes of delay. However, despite significant consensus, most published studies fall short of providing clear recommendations for the improvement of project management practice. Moreover, the majority of recommendations are general and not devoted to solving the difficulties associated with particular causes of delay. This paper aims to demonstrate that the root cause of this state of affairs is that typical research into delay tends to be descriptive and explanatory, making it inadequate for solving persistent managerial problems in construction. It is contended that many problems in construction could be mitigated via alternative research approaches, i.e. action and constructive research. Such prescriptive research methods can assist in the development and implementation of innovative tools tackling managerial problems of construction, including that of delay. In so doing, those methods will better connect research and practice, and thus strengthen the relevance of academic construction management.

Gastrointestinal foreign bodies in dogs and cats: a retrospective study of 208 cases

Abstract: Objectives:To establish predilection sites of obstruction and to investigate clinical factors associated with a poor outcome. Methods:A retrospective study of 208 consecutive cases over a 48-month period from first-opinion practice. Results:Overall, 91 per cent of cases recovered with higher survival rates from discrete foreign bodies (94 per cent in dogs and 100 per cent in cats) as opposed to linear foreign bodies (80 per cent in dogs and 63 per cent in cats). English bull terriers, springer spaniels, Staffordshire bull terriers, Border collies and Jack Russell terriers were over-represented. In dogs, 63 per cent of obstructions occurred in the jejunum but foreign objects were encountered at all points along the gastrointestinal tract. A longer duration of clinical signs, the presence of a linear foreign body and multiple intestinal procedures were associated with significantly increased mortality. Neither the degree of obstruction (partial or complete) nor the location of the foreign body was shown to have a significant influence on survival. Clinical Significance:Prompt presentation, diagnosis and surgical intervention improve the outcome of gastrointestinal obstruction by foreign bodies. At surgery, the minimal number of intestinal procedures should be performed to restore the integrity of the alimentary tract.

Should project management be based on theories of economics or production

Abstract: According to adherents of lean construction, project management theorists and practitioners, when drawing from the concepts and principles of economics, have neglected the management of production. The consequences of this neglect are said to include poor control (low reliability) of handoffs between design, supply and construction specialists, and a tendency to promote adversarial relationships – reducing value delivered and increasing waste. There is increasing agreement in the construction community that these problems must be solved and that the production perspective must be integrated into project management theory and practice. But how is it best to do so? Is it a matter of supplementing existing project management theory and practice with an additional perspective, or should we start from a conceptualization of projects as temporary production systems? This paper explores the alternative of subordinating the economics-based theory of project management to the theory of production. A recent synthes...