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Institution

University of Salford

EducationSalford, Manchester, United Kingdom
About: University of Salford is a education organization based out in Salford, Manchester, United Kingdom. It is known for research contribution in the topics: Population & Thin film. The organization has 13049 authors who have published 22957 publications receiving 537330 citations. The organization is also known as: University of Salford Manchester & The University of Salford Manchester.


Papers
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Journal ArticleDOI
Ian Watson1
TL;DR: By describing four applications of case-based reasoning (CBR), that variously use: nearest neighbour, induction, fuzzy logic and SQL, the author shows that CBR is a methodology and not a technology.
Abstract: This paper asks whether case-based reasoning is an artificial intelligence (AI) technology like rule-based reasoning, neural networks or genetic algorithms or whether it is better described as a methodology for problem solving, that may use any appropriate technology. By describing four applications of case-based reasoning (CBR), that variously use: nearest neighbour, induction, fuzzy logic and SQL, the author shows that CBR is a methodology and not a technology. The implications of this are discussed.

404 citations

Journal ArticleDOI
15 Oct 2008-PLOS ONE
TL;DR: Human tuberculosis was confirmed by morphological and molecular methods in a population living in one of the first villages with evidence of agriculture and animal domestication and gave support to the theory of a long-term co-existence of host and pathogen.
Abstract: Background: Mycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its host over millennia. This is supported by skeletal evidence of the disease in early humans, and inferred from M. tuberculosis genomic analysis. Direct examination of ancient human remains for M. tuberculosis biomarkers should aid our understanding of the nature of prehistoric tuberculosis and the host/pathogen relationship.Methodology/Principal Findings: We used conventional PCR to examine bone samples with typical tuberculosis lesions from a woman and infant, who were buried together in the now submerged site of Atlit-Yam in the Eastern Mediterranean, dating from 9250-8160 years ago. Rigorous precautions were taken to prevent contamination, and independent centers were used to confirm authenticity of findings. DNA from five M. tuberculosis genetic loci was detected and had characteristics consistent with extant genetic lineages. High performance liquid chromatography was used as an independent method of verification and it directly detected mycolic acid lipid biomarkers, specific for the M. tuberculosis complex.Conclusions/Significance: Human tuberculosis was confirmed by morphological and molecular methods in a population living in one of the first villages with evidence of agriculture and animal domestication. The widespread use of animals was not a source of infection but may have supported a denser human population that facilitated transmission of the tubercle bacillus. The similarity of the M. tuberculosis genetic signature with those of today gives support to the theory of a long-term co-existence of host and pathogen.

401 citations

Journal ArticleDOI
TL;DR: In this article, four forecasting methods, Simple Moving Average (SMA), 13 periods, Single Exponential Smoothing (SES), and a new method (based on Croston's approach) were compared on 3000 real intermittent demand data series from the automotive industry.

400 citations

Journal ArticleDOI
TL;DR: Estrogen treatment increased the extent of wound healing in both males and females with a decrease in wound size at day 7, increased collagen levels at both days 7 and 80, and increased day 7 fibronectin levels.
Abstract: The effects of intrinsic aging on the cutaneous wound healing process are profound, and the resulting acute and chronic wound morbidity imposes a substantial burden on health services. We have investigated the effects of topical estrogen on cutaneous wound healing in healthy elderly men and women, and related these effects to the inflammatory response and local elastase levels, an enzyme known to be up-regulated in impaired wound healing states. Eighteen health status-defined females (mean age, 74.4 years) and eighteen males (mean age, 70.7 years) were randomized in a double-blind study to either active estrogen patch or identical placebo patch attached for 24 hours to the upper inner arm, through which two 4-mm punch biopsies were made. The wounds were excised at either day 7 or day 80 post-wounding. Compared to placebo, estrogen treatment increased the extent of wound healing in both males and females with a decrease in wound size at day 7, increased collagen levels at both days 7 and 80, and increased day 7 fibronectin levels. In addition, estrogen enhanced the strength of day 80 wounds. Estrogen treatment was associated with a decrease in wound elastase levels secondary to reduced neutrophil numbers, and decreased fibronectin degradation. In vitro studies using isolated human neutrophils indicate that one mechanism underlying the altered inflammatory response involves both a direct inhibition of neutrophil chemotaxis by estrogen and an altered expression of neutrophil adhesion molecules. These data demonstrate that delays in wound healing in the elderly can be significantly diminished by topical estrogen in both male and female subjects.

399 citations

Journal ArticleDOI
TL;DR: This paper identifies a number of mechanisms that might give rise to the expected outcomes that are currently implicit within the design of the intervention and hypotheses specified within the trials evaluating the use of HRQoL measures in clinical practice and examines how far current clinical practice matches these mechanisms.

396 citations


Authors

Showing all 13134 results

NameH-indexPapersCitations
Hongjie Dai197570182579
Michael P. Lisanti15163185150
Matthew Jones125116196909
David W. Denning11373666604
Wayne Hall111126075606
Richard Gray10980878580
Christopher E.M. Griffiths10867147675
Thomas P. Davis10772441495
Nicholas Tarrier9232625881
David M. A. Mann8833843292
Ajith Abraham86111331834
Federica Sotgia8524728751
Mike Hulme8430035436
Robert N. Foley8426031580
Richard Baker8351422970
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202331
2022139
2021880
2020888
2019842
2018781