University of Salford

About: University of Salford is a education organization based out in Salford, Manchester, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 13049 authors who have published 22957 publications receiving 537330 citations. The organization is also known as: University of Salford Manchester & The University of Salford Manchester.

Patient survival after D-1 and D-2 resections for gastric cancer: long-term results of the MRC randomized surgical trial

Abstract: Controversy still exists on the optimal surgical resection for potentially curable gastric cancer. Much better long-term survival has been reported in retrospective/non-randomized studies with D2 resections that involve a radical extended regional lymphadenectomy than with the standard D1 resections. In this paper we report the long-term survival of patients entered into a randomized study, with follow-up to death or 3 years in 96% of patients and a median follow-up of 6.5 years. In this prospective trial D1 resection (removal of regional perigastric nodes) was compared with D2 resection (extended lymphadenectomy to include level 1 and 2 regional nodes). Central randomization followed a staging laparotomy. Out of 737 patients with histologically proven gastric adenocarcinoma registered, 337 patients were ineligible by staging laparotomy because of advanced disease and 400 were randomized. The 5-year survival rates were 35% for D1 resection and 33% for D2 resection (difference -2%, 95% CI = -12%-8%). There was no difference in the overall 5-year survival between the two arms (HR = 1.10, 95% CI 0.87-1.39, where HR > 1 implies a survival benefit to D1 surgery). Survival based on death from gastric cancer as the event was similar in the D1 and D2 groups (HR = 1.05, 95% CI 0.79-1.39) as was recurrence-free survival (HR = 1.03, 95% CI 0.82-1.29). In a multivariate analysis, clinical stages II and III, old age, male sex and removal of spleen and pancreas were independently associated with poor survival. These findings indicate that the classical Japanese D2 resection offers no survival advantage over D1 surgery. However, the possibility that D2 resection without pancreatico-splenectomy may be better than standard D1 resection cannot be dismissed by the results of this trial.

A critical perspective on action research as a method for information systems research

Abstract: This paper reviews the origins, techniques and roles associated with action research into information systems (IS). Many consider the approach to be the paragon of post-positivist research methods, yet it has a cloudy history among the social sciences. The paper summarizes the rigorous approach to action research and suggests certain domains of ideal use (such as systems development methodology). For those faced with conducting, reviewing or examining action research, the paper discusses various problems, opportunities and strategies.

Systematic methodological review: developing a framework for a qualitative semi-structured interview guide

Abstract: Aim: To produce a framework for the development of a qualitative semi-structured interview guide. Background: Rigorous data collection procedures fundamentally influence the results of studies. The semi-structured interview is a common data collection method, but methodological research on the development of a semi-structured interview guide is sparse. Design: Systematic methodological review. Data Sources: We searched PubMed, CINAHL, Scopus and Web of Science for methodological papers on semi-structured interview guides from October 2004 - September 2014. Having examined 2,703 titles and abstracts and 21 full texts, we finally selected ten papers. Review methods: We analysed the data using the qualitative content analysis method. Results: Our analysis resulted in new synthesized knowledge on the development of a semistructured interview guide, including five phases: 1) identifying the prerequisites for using semi-structured interviews; 2) retrieving and using previous knowledge; 3) formulating the preliminary semi-structured interview guide; 4) pilot testing the guide; and 5) presenting the complete semi-structured interview guide. Conclusion: Rigorous development of a qualitative semi-structured interview guide contributes to the objectivity and trustworthiness of studies and makes the results more plausible. Researchers should consider using this five-step process to develop a semistructured interview guide and justify the decisions made during it.

Genome-wide association study identifies 74 loci associated with educational attainment

Abstract: Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.

Magnetic order and phase transformation in Ni2MnGa

Abstract: Magnetization, magnetic susceptibility, optical microscopy, X-ray diffraction and neutron diffraction measurements have been made on a quenched sample of Ni2MnGa. Room-temperature neutron diffraction patterns indicate a highly ordered Heusler alloy, L21 type, structure. The alloy is ferromagnetic with a Curie temperature of 376 K, and a magnetic moment of 4·17μB largely confined to the Mn sites, but probably with a small moment <07·3μB associated with the Ni sites. A martensitic phase transition to a complex tetragonal structure occurs on cooling below 202 K. Neutron diffraction oscillation photographs taken using the D12 facility at Institut Laue Langevin, Grenoble, and low-temperature powder neutron diffraction data enabled details of the low temperature crystallographic superlattice and magnetic structure to be determined. Reasons for the structural transformation are discussed.