University of Salford

About: University of Salford is a education organization based out in Salford, Manchester, United Kingdom. It is known for research contribution in the topics: Population & Thin film. The organization has 13049 authors who have published 22957 publications receiving 537330 citations. The organization is also known as: University of Salford Manchester & The University of Salford Manchester.

Relating oxygen partial pressure, saturation and content: the haemoglobin–oxygen dissociation curve

Abstract: The delivery of oxygen by arterial blood to the tissues of the body has a number of critical determinants including blood oxygen concentration (content), saturation (S O2 ) and partial pressure, haemoglobin concentration and cardiac output, including its distribution. The haemoglobin-oxygen dissociation curve, a graphical representation of the relationship between oxygen satur-ation and oxygen partial pressure helps us to understand some of the principles underpinning this process. Historically this curve was derived from very limited data based on blood samples from small numbers of healthy subjects which were manipulated in vitro and ultimately determined by equations such as those described by Severinghaus in 1979. In a study of 3524 clinical specimens, we found that this equation estimated the S O2 in blood from patients with normal pH and S O2 >70% with remarkable accuracy and, to our knowledge, this is the first large-scale validation of this equation using clinical samples. Oxygen saturation by pulse oximetry (S pO2 ) is nowadays the standard clinical method for assessing arterial oxygen saturation, providing a convenient, pain-free means of continuously assessing oxygenation, provided the interpreting clinician is aware of important limitations. The use of pulse oximetry reduces the need for arterial blood gas analysis (S aO2 ) as many patients who are not at risk of hypercapnic respiratory failure or metabolic acidosis and have acceptable S pO2 do not necessarily require blood gas analysis. While arterial sampling remains the gold-standard method of assessing ventilation and oxygenation, in those patients in whom blood gas analysis is indicated, arterialised capillary samples also have a valuable role in patient care. The clinical role of venous blood gases however remains less well defined.

Urban ecological security : a new urban paradigm?

Abstract: The term ‘ecological security’ is usually used in relation to attempts to safeguard flows of ecological resources, infrastructure and services at the national scale. But increasing concerns over ‘urban ecological security’ (UES) are now giving rise to strategies to reconfigure cities and their infrastructures in ways that help to secure their ecological and material reproduction. Yet cities have differing capacities and capabilities for developing strategic responses to the opportunities and constraints of key UES concerns. These include resource constraints and climate change, and consequently these newly emerging strategies may selectively privilege particular urban areas and particular social interests over others. In this article, we focus on world cities and outline the challenges posed by the growing concern for UES. We review the emerging responses that may increasingly form a new dominant ‘logic’ of infrastructure provision, which we characterize as Secure Urbanism and Resilient Infrastructure (SURI). We conclude by addressing the extent to which this new dominant ‘logic’ underpins a new strategy of accumulation or more ‘progressive’ politics by outlining alternatives to SURI, possibilities for shaping SURI more ‘progressively’ and developing an agenda for future research.

Do SMEs do Knowledge Management? Or Simply Manage what they Know?

Abstract: Recent studies of knowledge management indicate that the growth of interest in this area is primarily focused on the larger organization. Not only do large firms feature in the majority of published case studies but also their employees are regular contributors to conference proceedings.This article addresses the comparatively under-researched issue of knowledge and its management in small businesses. Looking beyond formal Knowledge Management (KM) initiatives and structures, emphasis is placed upon the importance of informal knowledge processes.Two related propositions are made: first, knowledge is managed by organizations without use of the language and concepts of KM and accompanying formal KM structures, and that this behaviour might uncontroversially be called `informal' knowledge management, and secondly, small firms are more likely to adopt such informal processes to manage knowledge.These propositions are explored within the context of small firms and the research revealed that small firms do indeed manage knowledge informally as part of their normal activities, without the use of the terminology and concepts of KM. However, contrary to expectations, on occasion some also engage in formal KM.