University of Salford

About: University of Salford is a education organization based out in Salford, Manchester, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 13049 authors who have published 22957 publications receiving 537330 citations. The organization is also known as: University of Salford Manchester & The University of Salford Manchester.

A literature synthesis of innovation in small construction firms: insights, ambiguities and questions

Abstract: Construction firms are being challenged to be more adept at successful innovation to better meet client needs and to enhance business competitiveness. The substantial contribution that small construction firms make to the output of the industry signifies the importance for this body of firms to improve their innovation performance if the performance of the industry as a whole is to move forward. The literature on innovation in small construction firms is synthesized and structured around a generic model to provide a holistic picture of our current knowledge. Significant gaps in the understanding and practice of innovation in small construction literature are identified, which severely hamper understanding of the myriad complex and systemically interactive issues embodied within the theory and practice of innovation. The gaps identified by this literature synthesis are the basis for a number of important questions that, the authors propose, form an integrating agenda for future research.

Educational interventions to improve handover in health care: a systematic review.

Abstract: Medical Education 2011: 45: 1081–1089 Context Effective handover within the health care setting is vital to patient safety. Despite published literature discussing strategies to improve handover, the extent to which educational interventions have been used and how such interventions relate to the published theoretical models of handover remain unclear. These issues were investigated through a systematic review of the literature. Methods Any studies involving educational interventions to improve handover amongst undergraduate or postgraduate doctors or nurses were considered. A standardised search of online databases was carried out independently by both authors and consensus reached on the inclusion of studies. Data extraction and quality assessment were also completed independently, after which a content analysis of interventions was conducted and key themes extracted. Results Ten studies met the inclusion criteria. Nine studies reported outcomes demonstrating improved attitudes or knowledge and skills, and one demonstrated transfer of skills to the workplace. Amongst the included studies, the strength of conclusions was variable. Poor reporting of interventions impeded replication. Analysis of available content revealed themes in three major areas: teamwork and leadership; professional responsibility with regard to error prevention, and information management systems. Methods used included exercises based on simulation and role-play, and group discussions or lectures focused on errors and patient safety. Conclusions There is a paucity of research describing educational interventions to improve handover and assessing their effectiveness. The quality of published studies is generally poor. Some evidence exists to demonstrate that skills can be transferred to the workplace, but none was found to demonstrate that interventions improve patient safety.

Making a case for offsite construction in China

Abstract: Purpose – The purpose of this paper is to establish manufactured construction as a good potential alternative to meet the growing housing needs of China.Design/methodology/approach – The paper uses literature review and case study as research methodologies. Literature review is used to identify the need for housing and establish the manufacturing prowess of China. The case study is used to look at how a similar problem has been tackled in the UK and then the case study findings are used to identify future direction for China.Findings – Findings suggest that there is an acute shortage of housing in China, and at the same time the manufacturing sector in China is very strong. Therefore, in order to meet the housing demand for the population, manufactured construction offers a very attractive and cost‐efficient alternative.Practical implications – Manufactured construction is an attractive alternative for China and therefore the government needs to encourage this sector through subsidies and tax benefits. Gi...

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication.

Abstract: Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells within different tumor types and is responsible for treatment failure. Cancer stem cells (CSCs) are a population of cells with stem cell-like properties that are considered to be the root cause of tumor heterogeneity, because of their ability to generate the full repertoire of cancer cell types. Moreover, CSCs have been invoked as the main drivers of metastatic dissemination and therapeutic resistance. As such, targeting CSCs may be a useful strategy to improve the effectiveness of classical anticancer therapies. Recently, metabolism has been considered as a relevant player in CSC biology, and indeed, oncogenic alterations trigger the metabolite-driven dissemination of CSCs. More interestingly, the action of metabolic pathways in CSC maintenance might not be merely a consequence of genomic alterations. Indeed, certain metabotypic phenotypes may play a causative role in maintaining the stem traits, acting as an orchestrator of stemness. Here, we review the current studies on the metabolic features of CSCs, focusing on the biochemical energy pathways involved in CSC maintenance and propagation. We provide a detailed overview of the plastic metabolic behavior of CSCs in response to microenvironment changes, genetic aberrations, and pharmacological stressors. In addition, we describe the potential of comprehensive metabolic approaches to identify and selectively eradicate CSCs, together with the possibility to ‘force’ CSCs within certain metabolic dependences, in order to effectively target such metabolic biochemical inflexibilities. Finally, we focus on targeting mitochondria to halt CSC dissemination and effectively eradicate cancer.