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Institution

University of San Carlos

EducationCebu City, Philippines
About: University of San Carlos is a education organization based out in Cebu City, Philippines. It is known for research contribution in the topics: Population & Genome-wide association study. The organization has 681 authors who have published 908 publications receiving 27785 citations.


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Journal ArticleDOI
Cristen J. Willer1, Ellen M. Schmidt1, Sebanti Sengupta1, Gina M. Peloso2  +316 moreInstitutions (87)
TL;DR: It is found that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index.
Abstract: Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

2,585 citations

Journal ArticleDOI
Georg Ehret1, Georg Ehret2, Georg Ehret3, Patricia B. Munroe4  +388 moreInstitutions (110)
06 Oct 2011-Nature
TL;DR: A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Abstract: Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.

1,829 citations

Journal ArticleDOI
Anubha Mahajan1, Min Jin Go, Weihua Zhang2, Jennifer E. Below3  +392 moreInstitutions (104)
TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.
Abstract: To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.

954 citations

Journal ArticleDOI
David P. Schmitt1, Jüri Allik2, Robert R. McCrae3, Verónica Benet-Martínez4, Lidia Alcalay5, Lara Ault6, Ivars Austers7, Kevin Bennett8, Gabriel Bianchi9, Fredric Boholst10, Mary Ann Borg Cunen11, Johan Braeckman12, Edwin G. Brainerd13, Leo Gerard A. Caral10, Gabrielle Caron14, María Martina Casullo15, Michael Cunningham6, Ikuo Daibo16, Charlotte J. S. De Backer12, Eros De Souza17, Rolando Díaz-Loving18, Glaucia Ribeiro Starling Diniz19, Kevin Durkin20, Marcela Echegaray21, Ekin Eremsoy22, Harald A. Euler23, Ruth Falzon11, Maryanne L. Fisher24, Dolores Foley25, Douglas P. Fry26, Sirspa Fry26, M. Arif Ghayur27, Debra L. Golden28, Karl Grammer, Liria Grimaldi29, Jamin Halberstadt30, Shamsul Haque31, Dora Herrera21, Janine Hertel32, Heather Hoffmann33, Danica Hooper25, Zuzana Hradilekova34, Jasna Hudek-Kene-Evi35, Jas Laile Suzana Binti Jaafar36, Margarita Jankauskaite37, Heidi Kabangu-Stahel, Igor Kardum35, Brigitte Khoury38, Hayrran Kwon39, Kaia Laidra5, Anton Laireiter40, Dustin Lakerveld41, Ada Lampert, Mary Anne Lauri11, Marguerite Lavallée14, Suk Jae Lee42, Luk Chung Leung43, Kenneth D. Locke44, Vance Locke20, Ivan Lukšík9, Ishmael Magaisa45, Dalia Marcinkeviciene37, André Mata46, Rui Mata46, Barry Mccarthy47, Michael E. Mills48, Nhlanhla Mkhize49, João Manuel Moreira46, Sérgio Moreira46, Miguel Moya50, M. Munyae51, Patricia Noller25, Adrian Opre52, Alexia Panayiotou53, Nebojša Petrović54, Karolien Poels12, Miroslav Popper9, Maria Poulimenou55, Volodymyr P'yatokh, Michel Raymond56, Ulf-Dietrich Reips57, Susan E. Reneau58, Sofía Rivera-Aragón18, Wade C. Rowatt59, Willibald Ruch60, Velko S. Rus61, Marilyn P. Safir62, Sonia Salas63, Fabio Sambataro29, Kenneth Sandnabba26, Marion K. Schulmeyer, Astrid Schütz32, Tullio Scrimali29, Todd K. Shackelford64, Phillip R. Shaver65, Francis J Sichona66, Franco Simonetti2, Tilahun Sineshaw67, Tom Speelman12, Spyros Spyrou68, H. Canan Sümer69, Nebi Sümer69, Marianna Supekova9, Tomasz Szlendak70, Robin Taylor71, Bert Timmermans72, William Tooke73, Ioannis Tsaousis74, F. S.K. Tungaraza66, Griet Vandermassen12, Tim Vanhoomissen72, Frank Van Overwalle72, Ine Vanwesenbeeck, Paul L. Vasey75, João Veríssimo46, Martin Voracek76, Wendy W.N. Wan77, Ta Wei Wang78, Peter Weiss79, Andik Wijaya, Liesbeth Woertman41, Gahyun Youn80, Agata Zupanèiè61, Mithila B. Sharan81 
Bradley University1, University of Tartu2, National Institutes of Health3, University of California4, Pontifical Catholic University of Chile5, University of Louisville6, University of Latvia7, Pennsylvania State University8, Slovak Academy of Sciences9, University of San Carlos10, University of Malta11, Ghent University12, Clemson University13, Laval University14, University of Buenos Aires15, Osaka University16, Illinois State University17, National Autonomous University of Mexico18, University of Brasília19, University of Western Australia20, University of Lima21, Boğaziçi University22, University of Kassel23, York University24, University of Queensland25, Åbo Akademi University26, Al Akhawayn University27, University of Hawaii at Manoa28, University of Catania29, University of Otago30, University of Dhaka31, Chemnitz University of Technology32, Knox College33, Comenius University in Bratislava34, University of Rijeka35, University of Malaya36, Vilnius University37, American University of Beirut38, Kwangju Health College39, University of Salzburg40, Utrecht University41, National Computerization Agency42, City University of Hong Kong43, University of Idaho44, University of Zimbabwe45, University of Lisbon46, University of Central Lancashire47, Loyola Marymount University48, University of KwaZulu-Natal49, University of Granada50, University of Botswana51, Babeș-Bolyai University52, University of Cyprus53, University of Belgrade54, KPMG55, University of Montpellier56, University of Zurich57, University of Alabama58, Baylor University59, Queen's University Belfast60, University of Ljubljana61, University of Haifa62, University of La Serena63, Florida Atlantic University64, University of California, Davis65, University of Dar es Salaam66, Ramapo College67, Cyprus College68, Middle East Technical University69, Nicolaus Copernicus University in Toruń70, University of the South Pacific71, Vrije Universiteit Brussel72, University at Albany, SUNY73, University of the Aegean74, University of Lethbridge75, University of Vienna76, University of Hong Kong77, Yuan Ze University78, Charles University in Prague79, Chonnam National University80, Indian Institutes of Technology81
TL;DR: The Big Five Inventory (BFI) is a self-report measure designed to assess the high-order personality traits of Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness as discussed by the authors.
Abstract: The Big Five Inventory (BFI) is a self-report measure designed to assess the high-order personality traits of Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness. As part of the International Sexuality Description Project, the BFI was translated from English into 28 languages and administered to 17,837 individuals from 56 nations. The resulting cross-cultural data set was used to address three main questions: Does the factor structure of the English BFI fully replicate across cultures? How valid are the BFI trait profiles of individual nations? And how are personality traits distributed throughout the world? The five-dimensional structure was robust across major regions of the world. Trait levels were related in predictable ways to self-esteem, sociosexuality, and national personality profiles. People from the geographic regions of South America and East Asia were significantly different in openness from those inhabiting other world regions. The discussion focuses on limitations of t...

876 citations

Journal ArticleDOI
Ron Do1, Cristen J. Willer2, Ellen M. Schmidt2, Sebanti Sengupta2  +263 moreInstitutions (83)
TL;DR: It is suggested that triglyceride-rich lipoproteins causally influence risk for CAD, and the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk.
Abstract: Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

817 citations


Authors

Showing all 689 results

NameH-indexPapersCitations
Barry M. Popkin15775190453
Linda S. Adair9538044455
David K. Guilkey541568050
Gabriela Paz-Bailey361504580
Luuk A.M. van der Wielen351524207
Armando Cáceres341174024
John S. Akin33673845
Jaime A. Tschen321543472
Nanette R. Lee31729480
Judith B. Borja27723633
Edcel J. Salumbides26962042
Beatriz López251192435
Luis C. Mejía22432671
W.A. Ortiz211821788
Antonieta Rodas21421094
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20233
202220
202182
202094
201998
201898