University of São Paulo

About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Health care. The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.

The many paths to fear.

Abstract: Fear is an emotion that has powerful effects on behaviour and physiology across animal species. It is accepted that the amygdala has a central role in processing fear. However, it is less widely appreciated that distinct amygdala outputs and downstream circuits are involved in different types of fear. Data show that fear of painful stimuli, predators and aggressive members of the same species are processed in independent neural circuits that involve the amygdala and downstream hypothalamic and brainstem circuits. Here, we discuss data supporting multiple fear pathways and the implications of this distributed system for understanding and treating fear.

Revisão sobre posturografia baseada em plataforma de força para avaliação do equilíbrio

Abstract: CONTEXTUALIZACAO: A manutencao do equilibrio e da orientacao corporal em humanos e garantida pelo adequado funcionamento do sistema de controle postural. A investigacao desse controle tem despertado interesse em profissionais de diversas areas, tais como, Fisioterapia, Educacao Fisica, Engenharia, Fisica, Medicina, Psicologia, entre outras. OBJETIVOS: Revisar os metodos de analise experimental de dados utilizados para investigacao do controle postural em seres humanos e demonstrar o calculo e rotinas de programacao das principais medidas utilizadas na avaliacao desse controle. CONCLUSAO: Os procedimentos experimentais e as medidas utilizadas na avaliacao do controle postural apresentados nesta revisao poderao auxiliar na padronizacao da investigacao do controle postural.

Age and Metallicity Distribution of the Galactic Bulge from Extensive Optical and Near-IR Stellar Photometry

Abstract: We present a new determination of the metallicity distribution, age, and luminosity function of the Galactic bulge stellar population. By combining near-IR data from the 2MASS survey, from the SOFI imager at ESO NTT and the NICMOS camera on board HST we were able to construct color-magnitude diagrams (CMD) and luminosity functions (LF) with large statistics and small photometric errors from the Asymptotic Giant Branch (AGB) and Red Giant Branch (RGB) tip down to ∼0.15 M� . This is the most extended and complete LF so far obtained for the galactic bulge. Similar near-IR data for a disk control field were used to decontaminate the bulge CMDs from foreground disk stars, and hence to set a stronger constraint on the bulge age, which we found to be as large as that of Galactic globular clusters, or >10 Gyr. No trace is found for any younger stellar population. Synthetic CMDs have been constructed to simulate the effect of photometric errors, blending, differential reddening, metallicity dispersion and depth effect in the comparison with the observational data. By combining the near-IR data with optical ones, from the Wide Field Imager at the ESO/MPG 2.2 m telescope, a disk-decontaminated (MK,V-K )C MD has been constructed and used to derive the bulge metallicity distribution, by comparison with empirical RGB templates. The bulge metallicity is found to peak at near solar value, with a sharp cutoff just above solar, and a tail towards lower metallicity that does not appreciably extend below (M/H) ∼− 1.5.

Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome

Abstract: Microorganisms living inside plants can promote plant growth and health, but their genomic and functional diversity remain largely elusive. Here, metagenomics and network inference show that fungal infection of plant roots enriched for Chitinophagaceae and Flavobacteriaceae in the root endosphere and for chitinase genes and various unknown biosynthetic gene clusters encoding the production of nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). After strain-level genome reconstruction, a consortium of Chitinophaga and Flavobacterium was designed that consistently suppressed fungal root disease. Site-directed mutagenesis then revealed that a previously unidentified NRPS-PKS gene cluster from Flavobacterium was essential for disease suppression by the endophytic consortium. Our results highlight that endophytic root microbiomes harbor a wealth of as yet unknown functional traits that, in concert, can protect the plant inside out.