Institution
University of São Paulo
Education•São Paulo, Brazil•
About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.
Topics: Population, Context (language use), Medicine, Health care, Immune system
Papers published on a yearly basis
Papers
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TL;DR: The results show that the electronic pressure-meter provides a sensitive, objective and quantitative mechanical nociceptive test that could be useful to characterize new nOCiceptive inflammatory mediators and also to evaluate new peripheral analgesic substances.
Abstract: The objective of the present investigation was to compare the sensitivity of an electronic nociceptive mechanical paw test with classical mechanical tests to quantify the intensity variation of inflammatory nociception. The electronic pressure-meter test consists of inducing the hindpaw flexion reflex by poking the plantar region with a polypropylene pipette tip adapted to a hand-held force transducer. This method was compared with the classical von Frey filaments test and with the rat paw constant pressure test, a modification of the Randall and Selitto test developed by our group. When comparing the three methods, the electronic pressure-meter and the rat paw constant pressure test, but not the von Frey filaments test, detected time vs treatment interactions in prostaglandin E2 (PGE2)-induced hypernociception. Both methods also detected the PGE2-induced hypernociception in dose- (50-400 ng/paw) and time- (1-4 h) dependent manners, and time vs treatment interactions induced by carrageenin (25-400 microg/paw). Furthermore, the electronic pressure-meter test was more sensitive at early times, whereas the constant pressure test was more sensitive at later times. Moreover, the electronic pressure-meter test detected the dose-dependent antinociceptive effect of local indomethacin (30-300 microg/paw) and dipyrone (80-320 microg/paw) on carrageenin- (200 microg/paw) and PGE2- (100 ng/paw) induced hypernociception, respectively, and also detected the ineffectiveness of indomethacin (300 microg) on the effect of PGE2. Our results show that the electronic pressure-meter provides a sensitive, objective and quantitative mechanical nociceptive test that could be useful to characterize new nociceptive inflammatory mediators and also to evaluate new peripheral analgesic substances.
453 citations
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Virginia Mason Medical Center1, University of Birmingham2, University of São Paulo3, University of Michigan4, Toronto General Hospital5, St Thomas' Hospital6, Aix-Marseille University7, University of Amsterdam8, University of Texas MD Anderson Cancer Center9, Keio University10, Queen Mary University of London11, Harvard University12, Katholieke Universiteit Leuven13, Tata Memorial Hospital14, University Hospitals Birmingham NHS Foundation Trust15, Trinity College, Dublin16, University of Cologne17, University of Queensland18, Erasmus University Rotterdam19
TL;DR: Standardized methods provide contemporary international benchmarks for reporting outcomes after esophagectomy, using a standardized dataset with specific definitions to prospectively collect international data to provide a benchmark for complications and outcomes associated with esphagectomy.
Abstract: Objective:Utilizing a standardized dataset with specific definitions to prospectively collect international data to provide a benchmark for complications and outcomes associated with esophagectomy.Summary of Background Data:Outcome reporting in oncologic surgery has suffered from the lack of a stand
453 citations
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University of Texas MD Anderson Cancer Center1, Harvard University2, Massachusetts Institute of Technology3, Baylor College of Medicine4, University of North Carolina at Chapel Hill5, Johns Hopkins University6, University of São Paulo7, University of Michigan8, Institute for Systems Biology9, University of Lausanne10, Memorial Sloan Kettering Cancer Center11, Translational Genomics Research Institute12, University of California, Santa Cruz13, Brigham and Women's Hospital14, University Health Network15, BC Cancer Agency16, Brown University17, Ludwig Maximilian University of Munich18, Royal North Shore Hospital19, Kolling Institute of Medical Research20, National Institutes of Health21, Arizona State University22, University of Würzburg23
TL;DR: Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.
453 citations
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Newman University1, University of Oxford2, Celal Bayar University3, University of Valencia4, University of Melbourne5, Janssen Pharmaceutica6, University of Glasgow7, University of Cambridge8, University of Lisbon9, Ludwig Maximilian University of Munich10, Newcastle University11, University of Cincinnati Academic Health Center12, Icahn School of Medicine at Mount Sinai13, University of Birmingham14, National Institutes of Health15, Helsinki University Central Hospital16, University of Barcelona17, University of Oslo18, Oslo University Hospital19, University of Lleida20, Dresden University of Technology21, Ankara University22, Cardiff University23, University of São Paulo24, French Institute of Health and Medical Research25, École Normale Supérieure26
TL;DR: In this article, the authors reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view of the association between bipolar disorder and cognitive impairment.
Abstract: Objective: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view. Method: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task. Results: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression. Conclusion: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment.
453 citations
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TL;DR: In this article, a new library of high resolution synthetic spectra is presented, ranging from the near-ultraviolet (300nm) to the nearinfrared (1.8m).
Abstract: Libraries of stellar spectra are fundamental tools for the study of stellar populations, and both empirical and synthetic libraries have been used for this purpose. In this paper, a new library of high resolution synthetic spectra is presented, ranging from the near-ultraviolet (300 nm) to the near-infrared (1.8 m). The library spans all the stellar types that are relevant to the integrated light of old and intermediate-age stellar populations in the involved spectral region (spectral types F through M and all luminosity classes). The grid was computed for metallicities ranging from [Fe/H] = –2.5 to +0.5, including both solar and α -enhanced ([ α /Fe] = 0.4) chemical compositions. The synthetic spectra are a good match to observations of stars throughout the stellar parameter space encompassed by the library and over the whole spectral region covered by the computations.
452 citations
Authors
Showing all 138091 results
Name | H-index | Papers | Citations |
---|---|---|---|
George M. Whitesides | 240 | 1739 | 269833 |
Peter Libby | 211 | 932 | 182724 |
Robert C. Nichol | 187 | 851 | 162994 |
Paul M. Thompson | 183 | 2271 | 146736 |
Terrie E. Moffitt | 182 | 594 | 150609 |
Douglas R. Green | 182 | 661 | 145944 |
Richard B. Lipton | 176 | 2110 | 140776 |
Robin M. Murray | 171 | 1539 | 116362 |
George P. Chrousos | 169 | 1612 | 120752 |
David A. Bennett | 167 | 1142 | 109844 |
Barry M. Popkin | 157 | 751 | 90453 |
David H. Adams | 155 | 1613 | 117783 |
Joao Seixas | 153 | 1538 | 115070 |
Matthias Egger | 152 | 901 | 184176 |
Ichiro Kawachi | 149 | 1216 | 90282 |