Institution
University of São Paulo
Education•São Paulo, Brazil•
About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Health care. The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.
Topics: Population, Health care, Transplantation, Immune system, Poison control
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this article, Cinahl et al. present a revision integradora que buscar and evaluar las evidencias disponibles sobre las intervenciones eficaces de enfermeria for prevencion de lesiones de piel en el paciente quirurgico, en el periodo transoperatorio, or como resultado del mismo.
Abstract: La toma de decisiones en la practica diaria del enfermero necesita ser basada en conocimiento cientifico. La practica basada en evidencias es una aproximacion que establece la utilizacion de resultados de investigaciones en la practica clinica, con la revision integradora como uno de sus recursos. La finalidad de esta revision integradora es buscar y evaluar las evidencias disponibles sobre las intervenciones eficaces de enfermeria para la prevencion de lesiones de piel en el paciente quirurgico, en el periodo transoperatorio, o como resultado del mismo. Utilizamos dos bases de datos, Cinahl y Medline, para la seleccion de los articulos, resultando en una muestra de 14 articulos. Tras el analisis de los articulos incluidos en la revision, los resultados de los estudios indicaron que los dispositivos considerados los mas eficaces en la prevencion de lesiones de piel fueron, sucesivamente, el sistema de colchon dinamico pulsante multi-celula, la almohada de polimero seco visco-elastico y almohadas con gel.
438 citations
••
TL;DR: Topological cell clustering is established as a well-performing calorimeter signal definition for jet and missing transverse momentum reconstruction in ATLAS and is exploited to apply a local energy calibration and corrections depending on the nature of the cluster.
Abstract: The reconstruction of the signal from hadrons and jets emerging from the proton–proton collisions at the Large Hadron Collider (LHC) and entering the ATLAS calorimeters is based on a three-dimensional topological clustering of individual calorimeter cell signals. The cluster formation follows cell signal-significance patterns generated by electromagnetic and hadronic showers. In this, the clustering algorithm implicitly performs a topological noise suppression by removing cells with insignificant signals which are not in close proximity to cells with significant signals. The resulting topological cell clusters have shape and location information, which is exploited to apply a local energy calibration and corrections depending on the nature of the cluster. Topological cell clustering is established as a well-performing calorimeter signal definition for jet and missing transverse momentum reconstruction in ATLAS.
438 citations
••
TL;DR: This review adds and details the textile perspective to the microplastics exploring nomenclature, characteristics and factors influencing emission, but also evidencing gaps in knowledge needed to overcome this issue.
438 citations
••
University of Manchester1, George Washington University2, Bradford Royal Infirmary3, Université libre de Bruxelles4, Hospital Italiano de Buenos Aires5, Kaiser Permanente6, Technion – Israel Institute of Technology7, University of Barcelona8, University of Pavia9, Marshfield Clinic10, University of Toronto11, University of Paris12, University Hospitals Coventry and Warwickshire NHS Trust13, University of Angers14, University of Pisa15, University of Liverpool16, McGill University17, French Institute of Health and Medical Research18, University of Oxford19, University of Santiago de Compostela20, St Mary's Hospital21, University of Colorado Boulder22, NHS Ayrshire and Arran23, University of Udine24, University Hospitals of Leicester NHS Trust25, University of Sydney26, Katholieke Universiteit Leuven27, Istituto Giannina Gaslini28, Monash University29, University of Brescia30, Leeds General Infirmary31, Belfast Health and Social Care Trust32, University of Nantes33, Kocaeli University34, Temple University35, Boston Children's Hospital36, University of Paris-Sud37, University of Greifswald38, HealthPartners39, Guy's and St Thomas' NHS Foundation Trust40, University of Helsinki41, Royal Children's Hospital42, University of São Paulo43, Pierre-and-Marie-Curie University44, Princess Margaret Hospital for Children45, Amrita Vishwa Vidyapeetham46, Aarhus University47, University of British Columbia48, Rikshospitalet–Radiumhospitalet49, University of Milan50, University of Liège51, Mater Dei Hospital52, Karolinska Institutet53, Tel Aviv University54, University of Utah55, Nottingham University Hospitals NHS Trust56, University of Basel57, University of Melbourne58, University Hospital of Wales59, Christian Medical College & Hospital60, Casa Sollievo della Sofferenza61, Ghent University62, VU University Amsterdam63, Mount Sinai St. Luke's and Mount Sinai Roosevelt64, University of Nottingham65, McMaster University66, University of Glasgow67
TL;DR: A robust relationship between mutations in all seven genes with increased type I interferon activity in cerebrospinal fluid and serum, and the increased expression of interferOn‐stimulated gene transcripts in peripheral blood is observed.
Abstract: Aicardi-Goutieres syndrome is an inflammatory disease occurring due to mutations in any of TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR or IFIH1. We report on 374 patients from 299 families with mutations in these seven genes. Most patients conformed to one of two fairly stereotyped clinical profiles; either exhibiting an in utero disease-onset (74 patients; 22.8% of all patients where data were available), or a post-natal presentation, usually within the first year of life (223 patients; 68.6%), characterized by a sub-acute encephalopathy and a loss of previously acquired skills. Other clinically distinct phenotypes were also observed; particularly, bilateral striatal necrosis (13 patients; 3.6%) and non-syndromic spastic paraparesis (12 patients; 3.4%). We recorded 69 deaths (19.3% of patients with follow-up data). Of 285 patients for whom data were available, 210 (73.7%) were profoundly disabled, with no useful motor, speech and intellectual function. Chilblains, glaucoma, hypothyroidism, cardiomyopathy, intracerebral vasculitis, peripheral neuropathy, bowel inflammation and systemic lupus erythematosus were seen frequently enough to be confirmed as real associations with the Aicardi-Goutieres syndrome phenotype. We observed a robust relationship between mutations in all seven genes with increased type I interferon activity in cerebrospinal fluid and serum, and the increased expression of interferon-stimulated gene transcripts in peripheral blood. We recorded a positive correlation between the level of cerebrospinal fluid interferon activity assayed within one year of disease presentation and the degree of subsequent disability. Interferon-stimulated gene transcripts remained high in most patients, indicating an ongoing disease process. On the basis of substantial morbidity and mortality, our data highlight the urgent need to define coherent treatment strategies for the phenotypes associated with mutations in the Aicardi-Goutieres syndrome-related genes. Our findings also make it clear that a window of therapeutic opportunity exists relevant to the majority of affected patients and indicate that the assessment of type I interferon activity might serve as a useful biomarker in future clinical trials.
437 citations
••
University of Geneva1, Institut d'Astrophysique de Paris2, Centre national de la recherche scientifique3, Janssen Pharmaceutica4, University of Bern5, University of Paris-Sud6, Spanish National Research Council7, University of Vienna8, University of São Paulo9, European Space Agency10, University of Liège11, Austrian Academy of Sciences12, Tel Aviv University13, University of Cologne14, Technical University of Berlin15
TL;DR: In this article, an intensive observational campaign carried out with HARPS at the 3.6 m telescope at La Silla on the star CoRoT-7 was reported, where several approaches were used to extract the radial velocity signal of the planet(s) from the stellar activity signal.
Abstract: We report on an intensive observational campaign carried out with HARPS at the 3.6 m telescope at La Silla on the star CoRoT-7. Additional simultaneous photometric measurements carried out with the Euler Swiss telescope have demonstrated that the observed radial velocity variations are dominated by rotational modulation from cool spots on the stellar surface. Several approaches were used to extract the radial velocity signal of the planet(s) from the stellar activity signal. First, a simple pre-whitening procedure was employed to find and subsequently remove periodic signals from the complex frequency structure of the radial velocity data. The dominant frequency in the power spectrum was found at 23 days, which corresponds to the rotation period of CoRoT-7. The 0.8535 day period of CoRoT-7b planetary candidate was detected with an amplitude of 3.3 m s −1 . Most other frequencies, some with amplitudes larger than the CoRoT-7b signal, are most likely associated with activity. A second approach used harmonic decomposition of the rotational period and up to the first three harmonics to filter out the activity signal from radial velocity variations caused by orbiting planets. After correcting the radial velocity data for activity, two periodic signals are detected: the CoRoT-7b transit period and a second one with a period of 3.69 days and an amplitude of 4 m s −1 . This second signal was also found in the pre-whitening analysis. We attribute the second signal to a second, more remote planet CoRoT-7c . The orbital solution of both planets is compatible with circular orbits. The mass of CoRoT-7b is 4.8 ± 0. 8( M⊕) and that of CoRoT-7c is 8.4 ± 0. 9( M⊕), assuming both planets are on coplanar orbits. We also investigated the false positive scenario of a blend by a faint stellar binary, and this may be rejected by the stability of the bisector on a nightly scale. According to their masses both planets belong to the super-Earth planet category. The average density of CoRoT-7b is ρ = 5.6 ± 1. 3gc m −3 , similar to the Earth. The CoRoT-7 planetary system provides us with the first insight into the physical nature of short period super-Earth planets recently detected by radial velocity surveys. These planets may be denser than Neptune and therefore likely made of rocks like the Earth, or a mix of water ice and rocks.
437 citations
Authors
Showing all 138091 results
Name | H-index | Papers | Citations |
---|---|---|---|
George M. Whitesides | 240 | 1739 | 269833 |
Peter Libby | 211 | 932 | 182724 |
Robert C. Nichol | 187 | 851 | 162994 |
Paul M. Thompson | 183 | 2271 | 146736 |
Terrie E. Moffitt | 182 | 594 | 150609 |
Douglas R. Green | 182 | 661 | 145944 |
Richard B. Lipton | 176 | 2110 | 140776 |
Robin M. Murray | 171 | 1539 | 116362 |
George P. Chrousos | 169 | 1612 | 120752 |
David A. Bennett | 167 | 1142 | 109844 |
Barry M. Popkin | 157 | 751 | 90453 |
David H. Adams | 155 | 1613 | 117783 |
Joao Seixas | 153 | 1538 | 115070 |
Matthias Egger | 152 | 901 | 184176 |
Ichiro Kawachi | 149 | 1216 | 90282 |