Institution
University of São Paulo
Education•São Paulo, Brazil•
About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Health care. The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.
Topics: Population, Health care, Transplantation, Immune system, Poison control
Papers published on a yearly basis
Papers
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TL;DR: The role that is played by the TLR4 signaling pathway in the inflammatory response and its modulation by saturated and omega-3 polyunsaturated fatty acids is described.
Abstract: Obesity leads to an inflammatory condition that is directly involved in the etiology of cardiovascular diseases, type 2 diabetes mellitus, and certain types of cancer. The classic inflammatory response is an acute reaction to infections or to tissue injuries, and it tends to move towards resolution and homeostasis. However, the inflammatory process that was observed in individuals affected by obesity and metabolic syndrome differs from the classical inflammatory response in certain respects. This inflammatory process manifests itself systemically and it is characterized by a chronic low-intensity reaction. The toll-like receptor 4 (TLR4) signaling pathway is acknowledged as one of the main triggers of the obesity-induced inflammatory response. The aim of the present review is to describe the role that is played by the TLR4 signaling pathway in the inflammatory response and its modulation by saturated and omega-3 polyunsaturated fatty acids. Studies indicate that saturated fatty acids can induce inflammation by activating the TLR4 signaling pathway. Conversely, omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid and docosahexaenoic acid, exert anti-inflammatory actions through the attenuation of the activation of the TLR4 signaling pathway by either lipopolysaccharides or saturated fatty acids.
416 citations
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TL;DR: In this article, a review of the literature on heavy-ion fusion at low energies is presented, with special emphasis given to the fusion of loosely bound stable and unstable projectiles, and the experimental challenges encountered in the measurement of the fusion cross section of these systems are pointed out.
415 citations
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TL;DR: In this paper, the Pierre Auger Observatory data was used to confirm the anisotropy of the arrival direction of the highest-energy cosmic rays with the highest energy, which are correlated with the positions of relatively nearby active galactic nuclei (AGN) at a confidence level of more than 99%.
415 citations
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Tongji University1, Woods Hole Oceanographic Institution2, Texas A&M University3, Lamont–Doherty Earth Observatory4, ETH Zurich5, Centre national de la recherche scientifique6, University of South Florida St. Petersburg7, Chinese Academy of Sciences8, Louisiana State University9, Oregon State University10, Macquarie University11, State Oceanic Administration12, Oeschger Centre for Climate Change Research13, Korean Ocean Research and Development Institute14, China University of Geosciences (Wuhan)15, University of São Paulo16, University of the Philippines17, China University of Geosciences (Beijing)18, Japan Agency for Marine-Earth Science and Technology19, Virginia Tech College of Natural Resources and Environment20
TL;DR: In this paper, the authors combined analyses of deep tow magnetic anomalies and International Ocean Discovery Program Expedition 349 cores to show that seafloor spreading started around 33 Ma in the northeastern South China Sea (SCS), but varied slightly by 1-2 Myr along the northern continent-ocean boundary.
Abstract: Combined analyses of deep tow magnetic anomalies and International Ocean Discovery Program Expedition 349 cores show that initial seafloor spreading started around 33 Ma in the northeastern South China Sea (SCS), but varied slightly by 1-2 Myr along the northern continent-ocean boundary (COB). A southward ridge jump of approximate to 20 km occurred around 23.6 Ma in the East Subbasin; this timing also slightly varied along the ridge and was coeval to the onset of seafloor spreading in the Southwest Subbasin, which propagated for about 400 km southwestward from approximate to 23.6 to approximate to 21.5 Ma. The terminal age of seafloor spreading is approximate to 15 Ma in the East Subbasin and approximate to 16 Ma in the Southwest Subbasin. The full spreading rate in the East Subbasin varied largely from approximate to 20 to approximate to 80 km/Myr, but mostly decreased with time except for the period between approximate to 26.0 Ma and the ridge jump (approximate to 23.6 Ma), within which the rate was the fastest at approximate to 70 km/Myr on average. The spreading rates are not correlated, in most cases, to magnetic anomaly amplitudes that reflect basement magnetization contrasts. Shipboard magnetic measurements reveal at least one magnetic reversal in the top 100 m of basaltic layers, in addition to large vertical intensity variations. These complexities are caused by late-stage lava flows that are magnetized in a different polarity from the primary basaltic layer emplaced during the main phase of crustal accretion. Deep tow magnetic modeling also reveals this smearing in basement magnetizations by incorporating a contamination coefficient of 0.5, which partly alleviates the problem of assuming a magnetic blocking model of constant thickness and uniform magnetization. The primary contribution to magnetic anomalies of the SCS is not in the top 100 m of the igneous basement.
415 citations
Authors
Showing all 138091 results
Name | H-index | Papers | Citations |
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George M. Whitesides | 240 | 1739 | 269833 |
Peter Libby | 211 | 932 | 182724 |
Robert C. Nichol | 187 | 851 | 162994 |
Paul M. Thompson | 183 | 2271 | 146736 |
Terrie E. Moffitt | 182 | 594 | 150609 |
Douglas R. Green | 182 | 661 | 145944 |
Richard B. Lipton | 176 | 2110 | 140776 |
Robin M. Murray | 171 | 1539 | 116362 |
George P. Chrousos | 169 | 1612 | 120752 |
David A. Bennett | 167 | 1142 | 109844 |
Barry M. Popkin | 157 | 751 | 90453 |
David H. Adams | 155 | 1613 | 117783 |
Joao Seixas | 153 | 1538 | 115070 |
Matthias Egger | 152 | 901 | 184176 |
Ichiro Kawachi | 149 | 1216 | 90282 |