University of São Paulo

About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.

The Hubble Space Telescope UV Legacy Survey of Galactic globular clusters – IX. The Atlas of multiple stellar populations

Abstract: We use high-precision photometry of red-giant-branch (RGB) stars in 57 Galactic globular clusters (GCs), mostly from the 'Hubble Space Telescope (HST ) UV Legacy Survey of Galactic GCs', to identify and characterize their multiple stellar populations. For each cluster the pseudo-two-colour diagram (or 'chromosome map') is presented, built with a suitable combination of stellar magnitudes in the F275W, F336W, F438W, and F814W filters that maximizes the separation between multiple populations. In the chromosome map of most GCs (type-I clusters), stars separate in two distinct groups that we identify with the first (1G) and the second generation (2G). This identification is further supported by noticing that 1G stars have primordial (oxygen-rich, sodium-poor) chemical composition, whereas 2G stars are enhanced in sodium and depleted in oxygen. This 1G-2G separation is not possible for a few GCs where the two sequences have apparently merged into an extended, continuous sequence. In some GCs (type-II clusters) the 1G and/or the 2G sequences appear to be split, hence displaying more complex chromosome maps. These clusters exhibit multiple subgiant branches (SGBs) also in purely optical colour-magnitude diagrams, with the fainter SGB joining into a red RGB which is populated by stars with enhanced heavy-element abundance. We measure the RGB width by using appropriate colours and pseudo-colours. When the metallicity dependence is removed, the RGB width correlates with the cluster mass. The fraction of 1G stars ranges from ~8 per cent to ~67 per cent and anticorrelates with the cluster mass, indicating that incidence and complexity of the multiple population phenomenon both increase with cluster mass.

Safety and side effects of cannabidiol, a Cannabis sativa constituent.

Abstract: Cannabidiol (CBD), a major nonpsychotropic constituent of Cannabis, has multiple pharmacological actions, including anxiolytic, antipsychotic, antiemetic and anti-inflammatory properties. However, little is known about its safety and side effect profile in animals and humans. This review describes in vivo and in vitro reports of CBD administration across a wide range of concentrations, based on reports retrieved from Web of Science, Scielo and Medline. The keywords searched were "cannabinoids", "cannabidiol" and "side effects". Several studies suggest that CBD is non-toxic in non-transformed cells and does not induce changes on food intake, does not induce catalepsy, does not affect physiological parameters (heart rate, blood pressure and body temperature), does not affect gastrointestinal transit and does not alter psychomotor or psychological functions. Also, chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. Conversely, some studies reported that this cannabinoid can induce some side effects, including inhibition of hepatic drug metabolism, alterations of in vitro cell viability, decreased fertilization capacity, and decreased activities of p-glycoprotein and other drug transporters. Based on recent advances in cannabinoid administration in humans, controlled CBD may be safe in humans and animals. However, further studies are needed to clarify these reported in vitro and in vivo side effects.

Seasonality of water and heat fluxes over a tropical forest in eastern amazonia

Abstract: We used the eddy covariance technique from July 2000 to July 2001 to measure the fluxes of sensible heat, water vapor, and CO2 between an old-growth tropical forest in eastern Amazonia and the atmosphere. Precipitation varied seasonally, with a wet season from mid-December 2000 to July 2001 characterized by successive rainy days, wet soil, and, relative to the dry season, cooler temperatures, greater cloudiness, and reduced incoming solar and net radiation. Average evapotranspiration decreased from 3.96 ± 0.65 mm/d during the dry season to 3.18 ± 0.76 mm/d during the wet season, in parallel with decreasing radiation and decreasing water vapor deficit. The average Bowen ratio was 0.17 ± 0.10, indicating that most of the incoming radiation was used for evaporation. The Bowen ratio was relatively low during the early wet season (December–March), as a result of increased evaporative fraction and reduced sensible heat flux. The seasonal decline in Bowen ratio and increase in evaporative fraction coincided with an increase in ecosystem CO2 assimilation capacity, which we attribute to the growth of new leaves. The evaporative fraction did not decline as the dry season progressed, implying that the forest did not become drought stressed. The roots extracted water throughout the top 250 cm of soil, and water redistribution, possibly by hydraulic lift, partially recharged the shallow soil during dry season nights. The lack of drought stress during the dry season was likely a consequence of deep rooting, and possibly vertical water movement, which allowed the trees to maintain access to soil water year round.

Distributions of charged hadrons associated with high transverse momentum particles in pp and Au plus Au collisions at root(S)(NN)=200 GeV

Abstract: Charged hadrons in 0.15 4 GeV/c are reconstructed in pp and Au+Au collisions at {radical}(s{sub NN})=200 GeV. The associated multiplicity and p{sub perpendicular} magnitude sum are found to increase from pp to central Au+Au collisions. The associated p{sub perpendicular} distributions, while similar in shape on the nearside, are significantly softened on the awayside in central Au+Au relative to pp and not much harder than that of inclusive hadrons. The results, consistent with jet quenching, suggest that the awayside fragments approach equilibration with the medium traversed.

Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease

Abstract: The identification of RNAs that are not translated into proteins was an important breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene expression. These non-coding RNAs can be divided into two main classes according to their length: short non-coding RNAs, such as microRNAs (miRNAs), and long non-coding RNAs (lncRNAs). The lncRNAs in association with other molecules can coordinate several physiological processes and their dysfunction may impact in several pathologies, including cancer and infectious diseases. They can control the flux of genetic information, such as chromosome structure modulation, transcription, splicing, messenger RNA (mRNA) stability, mRNA availability, and post-translational modifications. Long non-coding RNAs present interaction domains for DNA, mRNAs, miRNAs, and proteins, depending on both sequence and secondary structure. The advent of new generation sequencing has provided evidences of putative lncRNAs existence; however, the analysis of transcriptomes for their functional characterization remains a challenge. Here, we review some important aspects of lncRNA biology, focusing on their role as regulatory elements in gene expression modulation during physiological and disease processes, with implications in host and pathogens physiology, and their role in immune response modulation.