University of São Paulo

About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Health care. The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.

Cross-national epidemiology of DSM-IV major depressive episode

Abstract: Major depression is one of the leading causes of disability worldwide, yet epidemiologic data are not available for many countries, particularly low- to middle-income countries. In this paper, we present data on the prevalence, impairment and demographic correlates of depression from 18 high and low- to middle-income countries in the World Mental Health Survey Initiative. Major depressive episodes (MDE) as defined by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DMS-IV) were evaluated in face-to-face interviews using the World Health Organization Composite International Diagnostic Interview (CIDI). Data from 18 countries were analyzed in this report (n = 89,037). All countries surveyed representative, population-based samples of adults. The average lifetime and 12-month prevalence estimates of DSM-IV MDE were 14.6% and 5.5% in the ten high-income and 11.1% and 5.9% in the eight low- to middle-income countries. The average age of onset ascertained retrospectively was 25.7 in the high-income and 24.0 in low- to middle-income countries. Functional impairment was associated with recency of MDE. The female: male ratio was about 2:1. In high-income countries, younger age was associated with higher 12-month prevalence; by contrast, in several low- to middle-income countries, older age was associated with greater likelihood of MDE. The strongest demographic correlate in high-income countries was being separated from a partner, and in low- to middle-income countries, was being divorced or widowed. MDE is a significant public-health concern across all regions of the world and is strongly linked to social conditions. Future research is needed to investigate the combination of demographic risk factors that are most strongly associated with MDE in the specific countries included in the WMH.

Insights into social insects from the genome of the honeybee Apis mellifera

Abstract: Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A+T and CpG contents, lacks major transposon families, evolves more slowly, and is more similar to vertebrates for circadian rhythm, RNA interference and DNA methylation genes, among others. Furthermore, A. mellifera has fewer genes for innate immunity, detoxification enzymes, cuticle-forming proteins and gustatory receptors, more genes for odorant receptors, and novel genes for nectar and pollen utilization, consistent with its ecology and social organization. Compared to Drosophila, genes in early developmental pathways differ in Apis, whereas similarities exist for functions that differ markedly, such as sex determination, brain function and behaviour. Population genetics suggests a novel African origin for the species A. mellifera and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.

The Epochs of Early-Type Galaxy Formation as a Function of Environment

Abstract: The aim of this paper is to set constraints on the epochs of early-type galaxy formation through the archaeology of the stellar populations in local galaxies. Using our models of absorption-line indices that account for variable abundance ratios, we derive ages, total metallicities, and element ratios of 124 early-type galaxies in high- and low-density environments. The data are analyzed by comparison with mock galaxy samples created through Monte Carlo simulations taking the typical average observational errors into account, in order to eliminate artifacts caused by correlated errors. We find that all three parameters, age, metallicity, and ?/Fe ratio, are correlated with velocity dispersion. We show that these results are robust against recent revisions of the local abundance pattern at high metallicities. To recover the observed scatter we need to assume an intrinsic scatter of about 20% in age, 0.08?dex in [Z/H], and 0.05?dex in [?/Fe]. All low-mass objects with M* 1010 M? (? 130 km s-1) show evidence for the presence of intermediate-age stellar populations with low ?/Fe ratios. About 20% of the intermediate-mass objects with 1010 M*/M? 1011 [110 ?/(km s-1) 230; both elliptical and lenticular galaxies] must have either a young subpopulation or a blue horizontal branch. On the basis of the above relationships, valid for the bulk of the sample, we show that the Mg-? relation is mainly driven by metallicity, with similar contributions from the ?/Fe ratio (23%) and age (17%). We further find evidence for an influence of the environment on the stellar population properties. Massive early-type galaxies in low-density environments seem on average ~2?Gyr younger and slightly (~0.05-0.1?dex) more metal-rich than their counterparts in high-density environments. No offsets in the ?/Fe ratios are instead detected. With the aid of a simple chemical evolution model, we translate the derived ages and ?/Fe ratios into star formation histories. We show that most star formation activity in early-type galaxies is expected to have happened between redshifts ~3 and 5 in high-density environments and between redshifts 1 and 2 in low-density environments. We conclude that at least 50% of the total stellar mass density must have already formed at z ~ 1, in good agreement with observational estimates of the total stellar mass density as a function of redshift. Our results suggest that significant mass growth in the early-type galaxy population below z ~ 1 must be restricted to less massive objects, and a significant increase of the stellar mass density between redshifts 1 and 2 should be present, caused mainly by the field galaxy population. The results of this paper further imply the presence of vigorous star formation episodes in massive objects at z ~ 2-5 and evolved elliptical galaxies around z ~ 1, both observationally identified as SCUBA galaxies and extremely red objects, respectively.