Institution
University of São Paulo
Education•São Paulo, Brazil•
About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Health care. The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.
Topics: Population, Health care, Transplantation, Immune system, Poison control
Papers published on a yearly basis
Papers
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TL;DR: The data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes, which are common in human pancreatic neuroendocrine tumors.
Abstract: The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres and other genomic sites Because inactivating mutations of these genes are common in human pancreatic neuroendocrine tumors (PanNETs), we examined the telomere status of these tumors We found that 61% of PanNETs displayed abnormal telomeres that are characteristic of a telomerase-independent telomere maintenance mechanism termed ALT (alternative lengthening of telomeres) All of the PanNETs exhibiting these abnormal telomeres had ATRX or DAXX mutations or loss of nuclear ATRX or DAXX protein ATRX mutations also correlate with abnormal telomeres in tumors of the central nervous system These data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes
903 citations
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Christina Fitzmaurice1, Christina Fitzmaurice2, Tomi Akinyemiju3, Faris Lami4 +172 more•Institutions (95)
901 citations
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TL;DR: In an effort to unify the nomenclature of Trypanosoma cruzi, the causative agent of Chagas disease, an updated system was agreed upon at the Second Satellite Meeting that T. cruzi strains should be referred to by six discrete typing units.
Abstract: In an effort to unify the nomenclature of Trypanosoma cruzi, the causative agent of Chagas disease, an updated system was agreed upon at the Second Satellite Meeting. A consensus was reached that T. cruzi strains should be referred to by six discrete typing units (T. cruzi I-VI). The goal of a unified nomenclature is to improve communication within the scientific community involved in T. cruzi research. The justification and implications will be presented in a subsequent detailed report.
900 citations
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11 Aug 2005TL;DR: This paper describes a method to construct elliptic curves of prime order and embedding degree k = 12 and shows that the ability to handle log(D)/log(r) ~ (q–3)/(q–1) enables building curves with ρ ~ q/(q-1).
Abstract: Previously known techniques to construct pairing-friendly curves of prime or near-prime order are restricted to embedding degree $k \leqslant 6 $. More general methods produce curves over ${\mathbb F}_{p}$ where the bit length of p is often twice as large as that of the order r of the subgroup with embedding degree k; the best published results achieve ρ ≡ log(p)/log(r) ~ 5/4. In this paper we make the first step towards surpassing these limitations by describing a method to construct elliptic curves of prime order and embedding degree k = 12. The new curves lead to very efficient implementation: non-pairing operations need no more than ${\mathbb F}_{p^4}$ arithmetic, and pairing values can be compressed to one third of their length in a way compatible with point reduction techniques. We also discuss the role of large CM discriminants D to minimize ρ; in particular, for embedding degree k = 2q where q is prime we show that the ability to handle log(D)/log(r) ~ (q–3)/(q–1) enables building curves with ρ ~ q/(q–1).
899 citations
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TL;DR: This review has gathered information on current definitions, serotypes, lineages, virulence mechanisms, epidemiology, and diagnosis of the major diarrheagenic E. coli pathotypes.
896 citations
Authors
Showing all 138091 results
Name | H-index | Papers | Citations |
---|---|---|---|
George M. Whitesides | 240 | 1739 | 269833 |
Peter Libby | 211 | 932 | 182724 |
Robert C. Nichol | 187 | 851 | 162994 |
Paul M. Thompson | 183 | 2271 | 146736 |
Terrie E. Moffitt | 182 | 594 | 150609 |
Douglas R. Green | 182 | 661 | 145944 |
Richard B. Lipton | 176 | 2110 | 140776 |
Robin M. Murray | 171 | 1539 | 116362 |
George P. Chrousos | 169 | 1612 | 120752 |
David A. Bennett | 167 | 1142 | 109844 |
Barry M. Popkin | 157 | 751 | 90453 |
David H. Adams | 155 | 1613 | 117783 |
Joao Seixas | 153 | 1538 | 115070 |
Matthias Egger | 152 | 901 | 184176 |
Ichiro Kawachi | 149 | 1216 | 90282 |