scispace - formally typeset
Search or ask a question
Institution

University of São Paulo

EducationSão Paulo, Brazil
About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Health care. The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.


Papers
More filters
Journal ArticleDOI
22 Jul 2011-Science
TL;DR: The data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes, which are common in human pancreatic neuroendocrine tumors.
Abstract: The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres and other genomic sites Because inactivating mutations of these genes are common in human pancreatic neuroendocrine tumors (PanNETs), we examined the telomere status of these tumors We found that 61% of PanNETs displayed abnormal telomeres that are characteristic of a telomerase-independent telomere maintenance mechanism termed ALT (alternative lengthening of telomeres) All of the PanNETs exhibiting these abnormal telomeres had ATRX or DAXX mutations or loss of nuclear ATRX or DAXX protein ATRX mutations also correlate with abnormal telomeres in tumors of the central nervous system These data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes

903 citations

Journal ArticleDOI
TL;DR: In an effort to unify the nomenclature of Trypanosoma cruzi, the causative agent of Chagas disease, an updated system was agreed upon at the Second Satellite Meeting that T. cruzi strains should be referred to by six discrete typing units.
Abstract: In an effort to unify the nomenclature of Trypanosoma cruzi, the causative agent of Chagas disease, an updated system was agreed upon at the Second Satellite Meeting. A consensus was reached that T. cruzi strains should be referred to by six discrete typing units (T. cruzi I-VI). The goal of a unified nomenclature is to improve communication within the scientific community involved in T. cruzi research. The justification and implications will be presented in a subsequent detailed report.

900 citations

Book ChapterDOI
11 Aug 2005
TL;DR: This paper describes a method to construct elliptic curves of prime order and embedding degree k = 12 and shows that the ability to handle log(D)/log(r) ~ (q–3)/(q–1) enables building curves with ρ ~ q/(q-1).
Abstract: Previously known techniques to construct pairing-friendly curves of prime or near-prime order are restricted to embedding degree $k \leqslant 6 $. More general methods produce curves over ${\mathbb F}_{p}$ where the bit length of p is often twice as large as that of the order r of the subgroup with embedding degree k; the best published results achieve ρ ≡ log(p)/log(r) ~ 5/4. In this paper we make the first step towards surpassing these limitations by describing a method to construct elliptic curves of prime order and embedding degree k = 12. The new curves lead to very efficient implementation: non-pairing operations need no more than ${\mathbb F}_{p^4}$ arithmetic, and pairing values can be compressed to one third of their length in a way compatible with point reduction techniques. We also discuss the role of large CM discriminants D to minimize ρ; in particular, for embedding degree k = 2q where q is prime we show that the ability to handle log(D)/log(r) ~ (q–3)/(q–1) enables building curves with ρ ~ q/(q–1).

899 citations

Journal ArticleDOI
TL;DR: This review has gathered information on current definitions, serotypes, lineages, virulence mechanisms, epidemiology, and diagnosis of the major diarrheagenic E. coli pathotypes.

896 citations


Authors

Showing all 138091 results

NameH-indexPapersCitations
George M. Whitesides2401739269833
Peter Libby211932182724
Robert C. Nichol187851162994
Paul M. Thompson1832271146736
Terrie E. Moffitt182594150609
Douglas R. Green182661145944
Richard B. Lipton1762110140776
Robin M. Murray1711539116362
George P. Chrousos1691612120752
David A. Bennett1671142109844
Barry M. Popkin15775190453
David H. Adams1551613117783
Joao Seixas1531538115070
Matthias Egger152901184176
Ichiro Kawachi149121690282
Network Information
Related Institutions (5)
Federal University of Rio de Janeiro
89.1K papers, 1.5M citations

98% related

State University of Campinas
104.6K papers, 1.8M citations

97% related

Universidade Federal do Rio Grande do Sul
89.4K papers, 1.4M citations

97% related

Universidade Federal de Minas Gerais
75.6K papers, 1.2M citations

96% related

Sao Paulo State University
100.4K papers, 1.3M citations

96% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023331
20222,547
202118,134
202017,960
201916,297