University of São Paulo

About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.

Analyzing and modeling real-world phenomena with complex networks: a survey of applications

Abstract: The success of new scientific areas can be assessed by their potential in contributing to new theoretical approaches and in applications to real-world problems. Complex networks have fared extremely well in both of these aspects, with their sound theoretical basis being developed over the years and with a variety of applications. In this survey, we analyze the applications of complex networks to real-world problems and data, with emphasis in representation, analysis and modeling. A diversity of phenomena are surveyed, which may be classified into no less than 11 areas, providing a clear indication of the impact of the field of complex networks.

Beneficial effects of the open lung approach with low distending pressures in acute respiratory distress syndrome : a prospective randomized study on mechanical ventilation

Abstract: Alveolar overdistention and cyclic reopening of collapsed alveoli have been implicated in the lung damage found in animals submitted to artificial ventilation. To test whether these phenomena are impairing the recovery of patients with acute respiratory distress syndrome (ARDS) submitted to conventional mechanical ventilation (MV), we evaluated the impact of a new ventilatory strategy directed at minimizing "cyclic parenchymal stretch." After receiving pre-established levels of hemodynamic, infectious, and general care, 28 patients with early ARDS were randomly assigned to receive either MV based on a new approach (NA, consisting of maintenance of end-expiratory pressures above the lower inflection point of the P x V curve, VT < 6 ml/kg, peak pressures < 40 cm H2O, permissive hypercapnia, and stepwise utilization of pressure-limited modes) or a conventional approach (C = conventional volume-cycled ventilation, VT = 12 ml/kg, minimum PEEP guided by FIO2 and hemodynamics and normal PaCO2 levels). Fifteen pa...

Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): objectives and design.

Abstract: Although low- and middle-income countries still bear the burden of major infectious diseases, chronic noncommunicable diseases are becoming increasingly common due to rapid demographic, epidemiologic, and nutritional transitions. However, information is generally scant in these countries regarding chronic disease incidence, social determinants, and risk factors. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information with respect to the development and progression of clinical and subclinical chronic diseases, particularly cardiovascular diseases and diabetes. In this report, the authors delineate the study's objectives, principal methodological features, and timeline. At baseline, ELSA-Brasil enrolled 15,105 civil servants from 5 universities and 1 research institute. The baseline examination (2008-2010) included detailed interviews, clinical and anthropometric examinations, an oral glucose tolerance test, overnight urine collection, a 12-lead resting electrocardiogram, measurement of carotid intima-media thickness, echocardiography, measurement of pulse wave velocity, hepatic ultrasonography, retinal fundus photography, and an analysis of heart rate variability. Long-term biologic sample storage will allow investigation of biomarkers that may predict cardiovascular diseases and diabetes. Annual telephone surveillance, initiated in 2009, will continue for the duration of the study. A follow-up examination is scheduled for 2012-2013.

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation.

Abstract: Diabetic patients frequently suffer from retinopathy, nephropathy, neuropathy and accelerated atherosclerosis. The loss of endothelial function precedes these vascular alterations. Here we report that activation of poly(ADP-ribose) polymerase (PARP) is an important factor in the pathogenesis of endothelial dysfunction in diabetes. Destruction of islet cells with streptozotocin in mice induced hyperglycemia, intravascular oxidant production, DNA strand breakage, PARP activation and a selective loss of endothelium-dependent vasodilation. Treatment with a novel potent PARP inhibitor, starting after the time of islet destruction, maintained normal vascular responsiveness, despite the persistence of severe hyperglycemia. Endothelial cells incubated in high glucose exhibited production of reactive nitrogen and oxygen species, consequent single-strand DNA breakage, PARP activation and associated metabolic and functional impairment. Basal and high-glucose-induced nuclear factor-kappaB activation were suppressed in the PARP-deficient cells. Our results indicate that PARP may be a novel drug target for the therapy of diabetic endothelial dysfunction.

Modelling the Galactic Interstellar Extinction Distribution in Three Dimensions

Abstract: Aims. The Two Micron All Sky Survey, along with the Stellar Population Synthesis Model of the Galaxy, developed in Besancon, is used to calculate the extinction distribution along different lines of sight. By combining many lines of sight, the large scale distribution of interstellar material can be deduced. Methods. The Galaxy model is used to provide the intrinsic colour of stars and their probable distances, so that the near infrared colour excess, and hence the extinction, may be calculated and its distance evaluated. Such a technique is dependent on the model used, however we are able to show that moderate changes in the model parameters result in insignificant changes in the predicted extinction. Results. This technique has now been applied to over 64000 lines of sight, each separated by 15', in the inner Galaxy (|l| < 100°, |b| < 10°). We have projected our three dimensional results onto a two dimensional plane in order to compare them with existing two dimensional extinction maps and CO surveys. We find that although differences exist due to the different methods used or the medium traced, the same large scale structures are visible in each of the different maps. Using our extinction map, we have derived the main characteristics of the large scale structure of the dust distribution. The scale height of the interstellar matter is found to be 125 +17 -7 pc. The dust distribution is found to be asymmetrically warped, in agreement with CO and HI observations of the ISM. However, the slope of the dust warp and the galactocentric distance where it starts are found to be smaller than the values measured for the external HI disc: for positive longitudes the angle is 0 = 89°, it starts at 8.7 kpc from the Galactic center and grows with a slope of 0.14, while at negative longitudes, the angle of the maximum is at θ = 272°, the starting radius 7.8 kpc and the slope 0.11. Finally, the presence of dust is detected in the Galactic bulge. It forms an elongated structure approximately 5.2 kpc long and lies at an angle of 30 ± 5° with respect to the Sun-Galactic centre direction. This may be interpreted as a dust lane along the Galactic bar. This resulting extinction map will be useful for studies of the inner Galaxy and its stellar populations.