scispace - formally typeset
Search or ask a question
Institution

University of São Paulo

EducationSão Paulo, Brazil
About: University of São Paulo is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & Health care. The organization has 136513 authors who have published 272320 publications receiving 5127869 citations. The organization is also known as: USP & Universidade de São Paulo.


Papers
More filters
Journal ArticleDOI
14 Feb 2018-BMJ
TL;DR: In this large prospective study, a 10% increase in the proportion of ultra-processed foods in the diet was associated with a significant increase of greater than 10% in risks of overall and breast cancer.
Abstract: Objective To assess the prospective associations between consumption of ultra-processed food and risk of cancer. Design Population based cohort study. Setting and participants 104 980 participants aged at least 18 years (median age 42.8 years) from the French NutriNet-Sante cohort (2009-17). Dietary intakes were collected using repeated 24 hour dietary records, designed to register participants’ usual consumption for 3300 different food items. These were categorised according to their degree of processing by the NOVA classification. Main outcome measures Associations between ultra-processed food intake and risk of overall, breast, prostate, and colorectal cancer assessed by multivariable Cox proportional hazard models adjusted for known risk factors. Results Ultra-processed food intake was associated with higher overall cancer risk (n=2228 cases; hazard ratio for a 10% increment in the proportion of ultra-processed food in the diet 1.12 (95% confidence interval 1.06 to 1.18); P for trend Conclusions In this large prospective study, a 10% increase in the proportion of ultra-processed foods in the diet was associated with a significant increase of greater than 10% in risks of overall and breast cancer. Further studies are needed to better understand the relative effect of the various dimensions of processing (nutritional composition, food additives, contact materials, and neoformed contaminants) in these associations. Study registration Clinicaltrials.gov NCT03335644.

586 citations

Journal ArticleDOI
TL;DR: Recent advances on a wide variety of fronts including the bacterial expression and characterization of mutants of TnC, TnI, and TnT; cross‐linking and fluorescence studies; and the determination of the crystal and nuclear magnetic resonance structures of synthetic and recombinant Troponin fragments and complexes between EF hand proteins and their target peptides have provided new insights into the nature of the interactions between troponin subunits are discussed.
Abstract: In a wide variety of cellular settings, from organelle transport to muscle contraction, Ca2+ binding to members of the EF hand family of proteins controls the interaction between actin and different myosins that are responsible for generating movement. In vertebrate skeletal and cardiac muscle the Ca(2+)-binding protein troponin C (TnC) is one subunit of the ternary troponin complex which, through its association with actin and tropomyosin on the thin filament, inhibits the actomyosin interaction at submicromolar Ca2+ concentrations and stimulates the interaction at micromolar Ca2+ concentrations. Because TnC does not interact directly with actin or tropomyosin, the Ca(2+)-binding signal must be transmitted to the thin filament via the other two troponin subunits: troponin I (TnI), the inhibitory subunit, and troponin T (TnT), the tropomyosin-binding subunit. Thus, the troponin complex is a Ca(2+)-sensitive molecular switch and the structures of and interactions between its components have been of great i...

585 citations

Journal ArticleDOI
TL;DR: In this paper, the electrochemical behavior of Ti-6Al-4V and Ti-7Al-7Nb alloys, commonly used implant materials, particularly for orthopaedic and osteosynthesis applications, was investigated together with that of Ti−13Nb−13Zr alloy in Hank's solution at 37°C.

585 citations

Journal ArticleDOI
TL;DR: This study aimed to present the general concepts and steps for the elaboration of an integrative review, as well as relevant aspects about the applicability of this method for health and nursing research.
Abstract: Evidence based practice is an approach that encourages the development and/or use of research results in clinical practice. Due to the quantity and complexity of information in health care, literature review methods need to be produced. Among such methods, we highlight the integrative review. Hence, this study aimed to present the general concepts and steps for the elaboration of an integrative review, as well as relevant aspects about the applicability of this method for health and nursing research. The integrative review is a research method that allows for the search, critical assessment, and synthesis of available evidence about the research theme. Its end product is the current stage of knowledge about the investigated theme, the implementation of effective interventions in health care and cost reduction, as well as the identification of gaps that indicate developments for future research.

584 citations

Journal ArticleDOI
Federica Spoto1, Federica Spoto2, Paolo Tanga2, Francois Mignard2  +498 moreInstitutions (86)
TL;DR: In this paper, the authors describe the processing of the Gaia DR2 data, and describe the criteria used to select the sample published in Gaia DR 2, and explore the data set to assess its quality.
Abstract: Context. The Gaia spacecraft of the European Space Agency (ESA) has been securing observations of solar system objects (SSOs) since the beginning of its operations. Data Release 2 (DR2) contains the observations of a selected sample of 14,099 SSOs. These asteroids have been already identified and have been numbered by the Minor Planet Center repository. Positions are provided for each Gaia observation at CCD level. As additional information, complementary to astrometry, the apparent brightness of SSOs in the unfiltered G band is also provided for selected observations.Aims. We explain the processing of SSO data, and describe the criteria we used to select the sample published in Gaia DR2. We then explore the data set to assess its quality.Methods. To exploit the main data product for the solar system in Gaia DR2, which is the epoch astrometry of asteroids, it is necessary to take into account the unusual properties of the uncertainty, as the position information is nearly one-dimensional. When this aspect is handled appropriately, an orbit fit can be obtained with post-fit residuals that are overall consistent with the a-priori error model that was used to define individual values of the astrometric uncertainty. The role of both random and systematic errors is described. The distribution of residuals allowed us to identify possible contaminants in the data set (such as stars). Photometry in the G band was compared to computed values from reference asteroid shapes and to the flux registered at the corresponding epochs by the red and blue photometers (RP and BP).Results. The overall astrometric performance is close to the expectations, with an optimal range of brightness G ~ 12 − 17. In this range, the typical transit-level accuracy is well below 1 mas. For fainter asteroids, the growing photon noise deteriorates the performance. Asteroids brighter than G ~ 12 are affected by a lower performance of the processing of their signals. The dramatic improvement brought by Gaia DR2 astrometry of SSOs is demonstrated by comparisons to the archive data and by preliminary tests on the detection of subtle non-gravitational effects.

584 citations


Authors

Showing all 138091 results

NameH-indexPapersCitations
George M. Whitesides2401739269833
Peter Libby211932182724
Robert C. Nichol187851162994
Paul M. Thompson1832271146736
Terrie E. Moffitt182594150609
Douglas R. Green182661145944
Richard B. Lipton1762110140776
Robin M. Murray1711539116362
George P. Chrousos1691612120752
David A. Bennett1671142109844
Barry M. Popkin15775190453
David H. Adams1551613117783
Joao Seixas1531538115070
Matthias Egger152901184176
Ichiro Kawachi149121690282
Network Information
Related Institutions (5)
Federal University of Rio de Janeiro
89.1K papers, 1.5M citations

98% related

State University of Campinas
104.6K papers, 1.8M citations

97% related

Universidade Federal do Rio Grande do Sul
89.4K papers, 1.4M citations

97% related

Universidade Federal de Minas Gerais
75.6K papers, 1.2M citations

96% related

Sao Paulo State University
100.4K papers, 1.3M citations

96% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023331
20222,547
202118,134
202017,960
201916,297