Showing papers by "University of Saskatchewan published in 2002"

An assessment of maturity from anthropometric measurements.

Abstract: Purpose: The range of variability between individuals of the same chronological age (CA) in somatic and biological maturity is large and especially accentuated around the adolescent growth spurt. Maturity assessment is an important consideration when dealing with adolescents, from both a research perspective and youth sports stratification. A noninvasive, practical method predicting years from peak height velocity (a maturity offset value) by using anthropometric variables is developed in one sample and cross-validated in two different samples. Methods: Gender specific multiple regression equations were calculated on a sample of 152 Canadian children aged 8-16 yr (79 boys; 73 girls) who were followed through adolescence from 1991 to 1997, The equations included three somatic dimensions (height, sitting height, and leg length), CA, and their interactions. The equations were cross-validated on a Combined sample of Canadian (71 boys, 40 girls measured from 1964 through 1973) and Flemish children (50 boys, 48 girls measured from 1985 through 1999). Results: The coefficient of determination (R2) for the boys' model was 0.92 and for the girls' model 0.91 the SEEs were 0.49 and 0.50, respectively, Mean difference between actual and predicted maturity offset for the verification samples was 0.24 (SD 0.65) yr in boys and 0,001 (SD 0.68) yr in girls. Conclusion: Although the cross-validation meets statistical standards or acceptance, caution 1, warranted with regard to implementation. It is recommended that maturity offset be considered as a categorical rather than a continuous assessment. Nevertheless, the equations presented are a reliable, noninvasive and a practical solution for the measure of biological maturity for matching adolescent athletes.

Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter?

Abstract: Bearing the public image of a deadly "gas of rotten eggs," hydrogen sulfide (H2S) can be generated in many types of mammalian cells. Functionally, H2S has been implicated in the induction of hippocampal long-term potentiation, brain development, and blood pressure regulation. By acting specifically on KATP channels, H2S can hyperpolarize cell membranes, relax smooth muscle cells, or decrease neuronal excitability. The endogenous metabolism and physiological functions of H2S position this gas well in the novel family of endogenous gaseous transmitters, termed "gasotransmitters." It is hypothesized that H2S is the third endogenous signaling gasotransmitter, besides nitric oxide and carbon monoxide. This positioning of H2S will open an exciting field-H2S physiology-encompassing realization of the interaction of H2S and other gasotransmitters, sulfurating modification of proteins, and the functional role of H2S in multiple systems. It may shed light on the pathogenesis of many diseases related to the abnormal metabolism of H2S.

A Descriptive Framework of Workspace Awareness for Real-Time Groupware

Abstract: Supporting awareness of others is an idea that holds promise for improving the usability of real-time distributed groupware. However, there is little principled information available about awareness that can be used by groupware designers. In this article, we develop a descriptive theory of awareness for the purpose of aiding groupware design, focusing on one kind of group awareness called i>workspace awareness. We focus on how small groups perform generation and execution tasks in medium-sized shared workspaces – tasks where group members frequently shift between individual and shared activities during the work session. We have built a three-part framework that examines the concept of workspace awareness and that helps designers understand the concept for purposes of designing awareness support in groupware. The framework sets out elements of knowledge that make up workspace awareness, perceptual mechanisms used to maintain awareness, and the ways that people use workspace awareness in collaboration. The framework also organizes previous research on awareness and extends it to provide designers with a vocabulary and a set of ground rules for analysing work situations, for comparing awareness devices, and for explaining evaluation results. The basic structure of the theory can be used to describe other kinds of awareness that are important to the usability of groupware.

Compositions of the Apatite-Group Minerals: Substitution Mechanisms and Controlling Factors

Abstract: The apatite-group minerals of the general formula, M10(ZO4)6X2 (M = Ca, Sr, Pb, Na…, Z = P, As, Si, V…, and X = F, OH, Cl…), are remarkably tolerant to structural distortion and chemical substitution, and consequently are extremely diverse in composition (e.g., Kreidler and Hummel 1970; McConnell 1973; Roy et al. 1978; Elliott 1994). Of particular interest is that a number of important geological, environmental/paleoenvironmental, and technological applications of the apatite-group minerals are directly linked to their chemical compositions. It is therefore fundamentally important to understand the substitution mechanisms and other intrinsic and external factors that control the compositional variation in apatites. The minerals of the apatite group are listed in Table 1⇓, and representative compositions of selected apatite-group minerals are given in Table 2⇓. Also, more than 100 compounds with the apatite structure have been synthesized (Table 3⇓). Phosphate apatites, particularly fluorapatite and hydroxylapatite, are by far the most common in nature and are often synonymous with “apatite(s)”. For example, fluorapatite is a ubiquitous accessory phase in igneous, metamorphic, and sedimentary rocks and a major constituent in phosphorites and certain carbonatites and anorthosites (McConnell 1973; Dymek and Owens 2001). Of particular importance in biological systems, hydroxylapatite and fluorapatite (and their carbonate-bearing varieties) are important mineral components of bones, teeth and fossils (McConnell 1973; Wright et al. 1984; Grandjean-Lecuyer et al. 1993; Elliott 1994; Wilson et al. 1999; Suetsugu et al. 2000; Ivanova et al. 2001). View this table: Table 1. Summary of the apatite-group minerals View this table: Table 2. Representative compositions and unit-cell parameters of selected apatite-group minerals. View this table: Table 3. Formulas of selected synthetic compounds with the apatite structure. Following Fleischer and Mandarino (1995), Table 1⇑ also includes melanocerite-(Ce), tritomite-(Ce), and tritomite-(Y), the compositions …

A controlled trial of rasagiline in early Parkinson disease: The tempo study

Abstract: CONTEXT Monotherapy with rasagiline mesylate may be useful in early Parkinson disease (PD). OBJECTIVE To evaluate the safety and efficacy of the selective monoamine oxidase type B inhibitor rasagiline. DESIGN Multicenter, 26-week, parallel-group, randomized, double-blind, placebo-controlled clinical trial. SETTING Academically based movement disorders clinics. PATIENTS Patients with early PD not requiring dopaminergic therapy (n = 404). INTERVENTION Research participants were randomized to rasagiline mesylate at dosages of 1 mg or 2 mg per day or matching placebo. A 1-week escalation period was followed by a 25-week maintenance period. MAIN OUTCOME MEASURE The primary prespecified measure of efficacy was the change in the total Unified Parkinson's Disease Rating Scal score between baseline and 26 weeks of treatment, comparing each active treatment group with the placebo group. RESULTS Monotherapy with rasagiline was effective in this 26-week study. The adjusted effect size for the total Unified Parkinson's Disease Rating Scale was -4.20 units comparing 1 mg of rasagiline and placebo (95% confidence interval, -5.66 to -2.73 units; P<.001) and -3.56 units comparing a 2-mg dosage and placebo (95% confidence interval, -5.04 to -2.08 units; P<.001). There were no meaningful differences in the frequency of adverse events or premature withdrawals among the treatment groups. CONCLUSIONS Rasagiline is effective as monotherapy for patients with early PD. The 2 dosages in this trial were both effective relative to placebo. Further study is warranted to evaluate the longer-term effects of rasagiline in PD.

An investigation of the total quality management survey based research published between 1989 and 2000: A literature review

Abstract: There has been a plethora of published research related to total quality management (TQM) in the last few decades. However, very few studies focused on cataloging critical factors of TQM. One of the objectives of this literature review was to investigate the state of TQM by examining and listing various TQM factors identified based on survey studies conducted in different countries and published in a variety of journals over the past decade. An examination of 76 survey studies that used an integrated approach to TQM showed that the TQM factors could be grouped under 25 categories. An analysis of the 347 survey based research articles published between 1989 and 2000 using these 25 factors as a framework revealed the most frequently covered TQM factors in the literature. Another goal of the paper was to analyse the objectives of these articles by year and type of journal they were published in to determine the trends in TQM survey based studies and recommend future direction for research. The analysis showed that the objectives of the 347 studies could be grouped under six categories.

Temporal trends in overweight and obesity in Canada, 1981-1996.

Abstract: OBJECTIVE: To assess changes in the prevalence of overweight and obesity among Canadian children and adults between 1981 and 1996 using recent recommendations for the classification of overweight and obesity. DESIGN: Epidemiological study comparing the prevalence of overweight and obesity from the 1981 Canada Fitness Survey (CFS) to the 1996 National Longitudinal Survey of Children and Youth (NLSCY) and the 1996 National Population Health Survey (NPHS). SUBJECTS: Adults 20–64 y of age and children 7–13 y of age from the CFS, NLSCY and NPHS. MEASUREMENTS: BMI was calculated from directly measured or self-reported body mass and height. For adults 20–64 y of age, overweight and obesity were defined as BMI≥25 kg/m2 and BMI≥30 kg/m2, respectively. Age- and sex-specific cut-off points for children that correspond to the adulthood categories were used to define overweight and obesity for children 7–13 y of age. RESULTS: The prevalence of overweight increased from 48 to 57% among men and from 30 to 35% among women, while the prevalence of obesity increased from 9 to 14% in men and from 8 to 12% in women. The corresponding increases were from 11 to 33% in boys and from 13 to 27% in girls for overweight and from 2 to 10% in boys and from 2 to 9% in girls for obesity. CONCLUSION: The results indicate dramatic increases in the prevalence of both overweight and obesity in Canada over the last 15 y, and the problem is particularly pronounced among children.

H2S-induced vasorelaxation and underlying cellular and molecular mechanisms

Abstract: H2S is endogenously generated in vascular smooth muscle cells. The signal transduction pathways involved in the vascular effects of H2S have been unclear and were investigated in the present study....

Factors that impact on quality of life in Parkinson's disease: results from an international survey

Abstract: Current management guidelines for the treatment of patients with Parkinson's disease (PD) are limited due to the lack of knowledge of factors that influence health‐related quality of life (HRQL). To assess the HRQL of people with PD, and to systematically identify and evaluate those factors (other than disease severity and medication, which could have an impact), we undertook a cross‐sectional, randomized selection, multicenter international survey of patients with PD, caregivers, and clinicians. Face‐to‐face interviews were conducted with subjects in six countries. Disease severity, medication, and other factors hypothesized to influence HRQL were assessed using a combination of specially developed questionnaires and validated instruments including the Parkinson's Disease Questionnaire‐39 (HRQL), Hoehn and Yahr Stage (disease severity), and Beck's Depression Inventory (BDI; depression). Multiple linear regression models were used to demonstrate whether the factors investigated contribute significantly to HRQL. The results obtained indicated that Hoehn and Yahr stage and medication explained only 17.3% of the variability in HRQL of patients with PD, although both were significant (R2 = 0.173, P < 0.05). Other factors increased the explanatory power to adjusted R2 = 0.597, with BDI being the most significant predictor of variability in HRQL (adjusted R2 = 0.582; P < 0.001), followed by “Satisfaction with the explanation of the condition at diagnosis” and “Current feelings of optimism” (both P < 0.05). These factors, in addition to disease severity and medication, explain 59.7% of the variability in HRQL across the population. In conclusion, depression (as measured by the BDI) in PD, “satisfaction with the explanation of the condition at diagnosis” and “current feelings of optimism” have a significant impact on HRQL. The completion of this initial analysis is the first step towards developing management guidelines that truly influence the HRQL of patients with PD. © 2001 Movement Disorder Society.

Pea Starch: Composition, Structure and Properties — A Review

Abstract: Recently, pea has developed into a major protein crop in Western Canada. In the search for new food protein resources, small commercial facilities in Canada have engaged in manufacturing protein concentrates from pea by air classification or wet milling techniques. However, the major products from these processes are either crude or refined pea starches. Pea starch has been utilized almost exclusively for industrial application. A major factor, which has an adverse effect on the widespread utilization of pea starch in food industry, it its high extent of retrogradation. This review summarizes the present knowledge on composition, structure and physiochemical properties of smooth and wrinkled seeded pea starches with a view to providing suggestions for needed research to improve the utilization of pea starches in the food industry.

BioMOBY: An open source biological web services proposal

Abstract: BioMOBY is an Open Source research project which aims to generate an architecture for the discovery and distribution of biological data through web services; data and services are decentralised, but the availability of these resources, and the instructions for interacting with them, are registered in a central location called MOBY Central. BioMOBY adds to the web services paradigm, as exemplified by Universal Data Discovery and Integration (UDDI), by having an object-driven registry query system with object and service ontologies. This allows users to traverse expansive and disparate data sets where each possible next step is presented based on the data object currently in-hand. Moreover, a path from the current data object to a desired final data object could be automatically discovered using the registry. Native BioMOBY objects are lightweight XML, and make up both the query and the response of a simple object access protocol (SOAP) transaction.

Low Glutathione and High Iron Govern the Susceptibility of Oligodendroglial Precursors to Oxidative Stress

Abstract: We have previously shown, using qualitative approaches, that oligodendroglial precursors are more readily damaged by free radicals than are astrocytes. In the present investigation we quantified the oxidative stress experienced by the cells using oxidation of dichlorofluorescin diacetate to dichlorofluorescein as a measure of oxidative stress; furthermore, we have delineated the physiological bases of the difference in susceptibility to oxidative stress found between oligodendroglial precursors and astrocytes. We demonstrate that (a) oligodendroglial precursors under normal culture conditions are under six times as much oxidative stress as astrocytes, (b) oxidative stress experienced by oligodendroglial precursors increases sixfold when exposed to 140 mW/m2 of blue light, whereas astrocytic oxidative stress only doubles, (c) astrocytes have a three times higher concentration of GSH than oligodendroglial precursors, (d) oligodendroglial precursors have >20 times higher iron content than do astrocytes, and (e) oxidative stress in oligodendroglial precursors can be prevented either by chelating intracellular free iron or by raising intracellular GSH levels to astrocytic values. We conclude that GSH plays a central role in preventing free radical-mediated damage in glia.

Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels.

Abstract: Previously, we have shown that alleles of the BM1500 microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid change of an arginine to a cysteine was identified in exon 2 of the leptin gene. A PCR-RFLP was designed and allele frequencies in four beef breeds were correlated with levels of carcass fat. The T allele was associated with fatter carcasses and the C allele with leaner carcasses. The frequencies of the SNP alleles among breeds indicated that British breeds have a higher frequency of the T allele whereas the continental breeds have a higher occurrence of the C allele. A ribonuclease protection assay was developed to quantify leptin mRNA in a separate group of animals selected by genotype. Animals homozygous for thymine expressed higher levels of leptin mRNA. This may suggest that the T allele, which adds an extra cysteine to the protein, imparts a partial loss of biological function and hence could be the causative mutation.

Changes in microbial community composition and function during a polyaromatic hydrocarbon phytoremediation field trial

Abstract: The purpose of this study was to investigate the mechanism by which phytoremediation systems promote hydrocarbon degradation in soil. The composition and degradation capacity of the bulk soil microbial community during the phytoremediation of soil contaminated with aged hydrocarbons was assessed. In the bulk soil, the level of catabolic genes involved in hydrocarbon degradation (ndoB, alkB, and xylE) as well as the mineralization of hexadecane and phenanthrene was higher in planted treatment cells than in treatment cells with no plants. There was no detectable shift in the 16S ribosomal DNA (rDNA) composition of the bulk soil community between treatments, but there were plant-specific and -selective effects on specific catabolic gene prevalence. Tall Fescue (Festuca arundinacea) increased the prevalence of ndoB, alkB, and xylE as well as naphthalene mineralization in rhizosphere soil compared to that in bulk soil. In contrast, Rose Clover (Trifolium hirtum) decreased catabolic gene prevalence and naphthalene mineralization in rhizosphere soil. The results demonstrated that phytoremediation systems increase the catabolic potential of rhizosphere soil by altering the functional composition of the microbial community. This change in composition was not detectable by 16S rDNA but was linked to specific functional genotypes with relevance to petroleum hydrocarbon degradation.

A Randomized Trial of the Effect of Community Pharmacist Intervention on Cholesterol Risk Management: The Study of Cardiovascular Risk Intervention by Pharmacists (SCRIP)

Abstract: general advice only, with minimal follow-up The primary end point was a composite of performance of a fasting cholesterol panel by the physician or addition or increase in dose of cholesterol-lowering medication Results: The external monitoring committee recommended early study termination owing to benefit Of the 675 patients enrolled, approximately 40% were women, and the average age was 64 years The primary end point was reached in 57% of intervention patients vs 31% in usual care (odds ratio, 30; 95% confidence interval, 2241; P001) Conclusions: A community-based intervention program improved the process of cholesterol management in high-risk patients This program demonstrates the value of community pharmacists working in collaboration with patients and physicians Arch Intern Med 2002;162:1149-1155

Are sex differences in navigation caused by sexually dimorphic strategies or by differences in the ability to use the strategies

Abstract: When navigating, women typically focus on landmarks within the environment, whereas men tend to focus on the Euclidean properties of the environment. However, it is unclear whether these observed differences in navigational skill result from disparate strategies or disparate ability. To remove this confound, the present study required participants to follow either landmark- or Euclidean-based instructions during a navigation task (either in the real-world or on paper). Men performed best when using Euclidean information, whereas women performed best when using landmark information, suggesting a dimorphic capacity to use these 2 types of spatial information. Further, a significant correlation was observed between the mental rotation task and the ability to use Euclidean information, but not the ability to use landmark information.

Pyrolysis of Lignins: Experimental and Kinetics Studies

Abstract: Lignins are generally used as a low grade fuel in the pulp and paper industry. In this work, pyrolysis of Alcell and Kraft lignins obtained from the Alcell process and Westvaco, respectively, was carried out in a fixed-bed reactor and in a thermogravimetric analyzer (TGA) using helium (13.4 mL/min/g of lignin) and nitrogen (50 mL/min/g of lignin), respectively. The reaction temperature was increased from 300 to 1073 K, while the heating rates were varied from 5 to 15 K/min. The gaseous products mainly consisted of H2, CO, CO2, CH4, and C2+. With increase in heating rate from 5 to 15 K/min both lignin conversion and hydrogen production increased from 56 to 65 wt % and from 25 to 31 mol %, respectively for fixed-bed pyrolysis reaction of Alcell lignin at 1073 K, whereas at the same condition the conversion and hydrogen production increased from 52 to 57 wt % and from 30 to 43 mol % for Kraft lignin. The distributed activation energy model (DAEM) was used to analyze complex reactions involved in the lignin p...

Economics of Crop Diversification and Soil Tillage Opportunities in the Canadian Prairies

Abstract: Annual crop production in the Canadian prairies is undergoing significant change. Traditional monoculture cereal cropping systems, which rely on frequent summer-fallowing and use of mechanical tillage, are being replaced by extended and diversified crop rotations together with the use of conservation tillage (minimum and zero-tillage) practices. This paper reviews the findings of western Canadian empirical studies that have examined the economic forces behind these land use and soil tillage changes. The evidence suggests that including oilseed and pulse crops in the rotation with cereal grains contributes to higher and more stable net farm income in most soil-climatic regions, despite a requirement for increased expenditures on purchased inputs. In the very dry Brown soil zone and drier regions of the Dark Brown soil zone where the production risk with stubble cropping is high, the elimination of summer fallow from the cropping system may not be economically feasible under present and near-future economic conditions. The use of conservation tillage practices in the management of mixed cropping systems is highly profitable in the more moist Black and Gray soil zones (compared with conventional mechanical tillage methods) because of significant yield advantages and substantial resource savings that can be obtained by substituting herbicides for the large amount of tillage that is normally used. However, in the Brown soil zone and parts of the Dark Brown soil zone, the short-term economic benefits of using conservation tillage practices are more marginal and often less profitable than comparable conventional tillage practices.

The impact of information sharing and ordering co‐ordination on supply chain performance

Abstract: This paper presents a study on the impacts of information sharing and ordering co‐ordination on the performance of a supply chain with one capacitated supplier and multiple retailers under demand uncertainty. In particular, a computer model is proposed to simulate inventory replenishment decisions by the retailers and production decisions by the supplier under different demand patterns and capacity tightness. It is found that information sharing and ordering co‐ordination significantly impact the supply chain performance in terms of both total cost and service level. It is also found that the value of sharing information and ordering co‐ordination is significantly affected by demand patterns and capacity tightness. Guidelines are developed for companies to share information and co‐ordinate orders under different conditions. These guidelines can help companies reduce costs and improve customer service levels in the supply chain.

Prediction of seasonal snow accumulation in cold climate forests

Abstract: Pomeroy, J. W., Gray, D. M., Hedstrom, N. R., Janowicz, J. R. (2002). Prediction of seasonal snow accumulation in cold climate forests. Hydrological Processes, 16(18), 3543-3558. 59th Eastern Snow Conference (ESC), Stowe, Vermont, 5-7 June 2002.

Polyamine research in plants – a changing perspective

Abstract: Our understanding of the precise role(s) of polyamines (PAs) in various plant developmental and morphogenetic processes has advanced considerably by the ability to manipulate PA biosynthetic pathways using polyamine biosynthesis inhibitors, PA- mutants and by adopting various transgenic strategies. The cDNA for almost every biosynthesis pathway enzyme has been isolated and cloned in a number of systems. This review briefly summarizes our current understanding of the genetic control of PA metabolism in different model plant systems.

Treatment of chronic pain with spinal cord stimulation versus alternative therapies: cost-effectiveness analysis.

Abstract: There is limited available research measuring the cost-effectiveness ofspinal cord stimulation (SCS), compared with best medical treatment/conventionalpain therapy (CPT). The purpose of this study was to tabulate the actual costs (inCanadian dollars) for a consecutive series of patients treated with SCS in a constanthealth care delivery environment and to compare the costs with those for a controlgroup treated in the same controlled environment.

Increased Methylglyoxal and Oxidative Stress in Hypertensive Rat Vascular Smooth Muscle Cells

Abstract: Methylglyoxal can yield advanced glycation end products via nonenzymatic glycation of proteins. Whether methylglyoxal contributes to the pathogenesis of hypertension has not been clear. The aim of the present study was to investigate whether the levels of methylglyoxal and methylglyoxal-induced advanced glycation end products were enhanced and whether methylglyoxal increased oxidative stress, activated nuclear factor-kappaB (NF-kappaB), and increased intracellular adhesion molecule-1 (ICAM-1) content in vascular smooth muscle cells from spontaneously hypertensive rats. Basal cellular levels of methylglyoxal and advanced glycation end products were more than 2-fold higher (P<0.05) in cells from hypertensive rats than from normotensive Wistar-Kyoto rats. This correlated with levels of oxidative stress and oxidized glutathione that were significantly higher in cells from hypertensive rats, whereas levels of glutathione and activities of glutathione reductase and glutathione peroxidase were significantly lower. Basal levels of nuclearly localized NF-kappaB p65 and ICAM-1 protein expression were higher in cells from hypertensive rats than from normotensive rats. Addition of exogenous methylglyoxal to the cultures induced a greater increase in oxidative stress and advanced glycation end products in cells from hypertensive rats compared with normotensive rats and significantly decreased the activities of glutathione reductase and glutathione peroxidase in cells of both rat strains. Methylglyoxal activated NF-kappaB p65 and increased ICAM-1 expression in hypertensive cells, which was inhibited by N-acetylcysteine. Our study demonstrates an elevated methylglyoxal level and advanced glycation end products in cells from hypertensive rats, and methylglyoxal increases oxidative stress, activates NF-kappaB, and enhances ICAM-1 expression. Our findings suggest that that elevated methylglyoxal and associated oxidative stress possibly contribute to the pathogenesis of hypertension.

Offender Treatment Attrition and its Relationship with Risk, Responsivity, and Recidivism:

Abstract: This investigation examined factors contributing to attrition from correctional treatment and the implication that treatment noncompletion may have for issues concerning risk, recidivism, and respo...

Clinical implications of a link between fetal alcohol spectrum disorder and attention-deficit hyperactivity disorder.

Abstract: Objective:To provide an overview of the animal and human research literature on the link between fetal alcohol spectrum disorder (FASD) and attention-deficit hyperactivity disorder (ADHD).Method:We...