Institution
University of Saskatchewan
Education•Saskatoon, Saskatchewan, Canada•
About: University of Saskatchewan is a education organization based out in Saskatoon, Saskatchewan, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 25021 authors who have published 52579 publications receiving 1483049 citations. The organization is also known as: USask.
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TL;DR: It is demonstrated that the typical and atypical antipsychotic drugs differentially regulate BDNF mRNA expression in rat hippocampus.
Abstract: Typical and atypical antipsychotic drugs, though both effective, act on different neurotransmitter receptors and are dissimilar in some clinical effects and side effects. The typical antipsychotic drug haloperidol has been shown to cause a decrease in the expression of brain-derived neurotrophic factor (BDNF), which plays an important role in neuronal cell survival, differentiation, and neuronal connectivity. However, it is still unknown whether atypical antipsychotic drugs similarly regulate BDNF expression. We examined the effects of chronic (28 days) administration of typical and atypical antipsychotic drugs on BDNF mRNA expression in the rat hippocampus using in situ hybridization. Quantitative analysis revealed that the typical antipsychotic drug haloperidol (1 mg/kg) down-regulated BDNF mRNA expression in both CA1 (P < 0.05) and dentate gyrus (P < 0.01) regions compared with vehicle control. In contrast, the atypical antipsychotic agents clozapine (10 mg/kg) and olanzapine (2.7 mg/kg) up-regulated BDNF mRNA expression in CA1, CA3, and dentate gyrus regions of the rat hippocampus compared with their respective controls (P < 0.01). These findings demonstrate that the typical and atypical antipsychotic drugs differentially regulate BDNF mRNA expression in rat hippocampus.
242 citations
TL;DR: In this paper, it was demonstrated that the main reason limiting the production of high levels of ethanol by brewing yeast is actually a nutritional deficiency, and that the yeast viability remains high, and the yeast can be repitched at least five times Supplementation does not increase the fermentative tolerance of the yeast to ethanol but increases the length and level of new yeast cell mass synthesis over that seen in unsupplemented wort.
Abstract: A number of economic and product quality advantages exist in brewing when high-gravity worts of 16 to 18% dissolved solids are fermented Above this level, production problems such as slow or stuck fermentations and poor yeast viability occur Ethanol toxicity has been cited as the main cause, as brewers' yeasts are reported to tolerate only 7 to 9% (vol/vol) ethanol The inhibitory effect of high osmotic pressure has also been implicated In this report, it is demonstrated that the factor limiting the production of high levels of ethanol by brewing yeasts is actually a nutritional deficiency When a nitrogen source, ergosterol, and oleic acid are added to worts up to 31% dissolved solids, it is possible to produce beers up to 162% (vol/vol) ethanol Yeast viability remains high, and the yeasts can be repitched at least five times Supplementation does not increase the fermentative tolerance of the yeasts to ethanol but increases the length and level of new yeast cell mass synthesis over that seen in unsupplemented wort (and therefore the period of more rapid wort attenuation) Glycogen, protein, and sterol levels in yeasts were examined, as was the importance of pitching rate, temperature, and degree of anaerobiosis The ethanol tolerance of brewers' yeast is suggested to be no different than that of sake or distillers' yeast
242 citations
McGill University1, University of British Columbia2, University of Calgary3, University of Ottawa4, Memorial University of Newfoundland5, University of Western Ontario6, University of Toronto7, University of Alberta8, Ottawa Hospital Research Institute9, Université du Québec à Trois-Rivières10, Montreal General Hospital11, Jewish General Hospital12, University of Saskatchewan13, Canadian Stroke Network14, Hôpital Maisonneuve-Rosemont15, Laval University16, University Health Network17, Queen Elizabeth II Health Sciences Centre18, Université de Sherbrooke19, St. Michael's Hospital20, University of Manitoba21, Université de Montréal22, Concordia University23, Lawson Health Research Institute24, Department of National Defence25
TL;DR: Use of home blood pressure monitoring to confirm a diagnosis of white coat syndrome and the recent evidence on blood pressure targets for patients with hypertension and diabetes are reviewed and continue to recommend a blood pressure target of less than 130/80 mm Hg.
241 citations
University of British Columbia1, University of Zurich2, University of Washington3, University of Bern4, Tel Aviv University5, University of Southern California6, University of Toronto7, University of Saskatchewan8, University of Geneva9, St. Marianna University School of Medicine10, Boston Children's Hospital11, Oregon Health & Science University12, University of Alberta13, Alberta Children's Hospital14, Université de Montréal15
TL;DR: The majority of caregivers intend to vaccinate their children against COVID-19, though uptake will likely be associated with specific factors such as child and caregiver demographics and vaccination history.
241 citations
TL;DR: Phosphorus fractionation indicated that the decline in P fertility was not a result of net export of P in the crop, but arises from the mineralisation of organic P and subsequent transformation of the surplus inorganic P to unavailable forms.
241 citations
Authors
Showing all 25277 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Tomas Hökfelt | 158 | 1033 | 95979 |
| Frederick Wolfe | 119 | 417 | 101272 |
| Christopher G. Goetz | 116 | 651 | 59510 |
| John P. Giesy | 114 | 1162 | 62790 |
| Helmut Kettenmann | 104 | 380 | 40211 |
| Paul M. O'Byrne | 104 | 605 | 56520 |
| Susan S. Taylor | 104 | 518 | 42108 |
| Keith A. Hobson | 103 | 653 | 41300 |
| Mark S. Tremblay | 100 | 541 | 43843 |
| James F. Fries | 100 | 369 | 83589 |
| Gordon McKay | 97 | 661 | 61390 |
| Jonathan D. Adachi | 96 | 589 | 31641 |
| Wenjun Zhang | 96 | 976 | 38530 |
| William C. Dement | 96 | 340 | 43014 |
| Chris Ryan | 95 | 971 | 34388 |