Institution
University of Saskatchewan
Education•Saskatoon, Saskatchewan, Canada•
About: University of Saskatchewan is a education organization based out in Saskatoon, Saskatchewan, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 25021 authors who have published 52579 publications receiving 1483049 citations. The organization is also known as: USask.
Papers published on a yearly basis
Papers
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TL;DR: Information on the rate of plaque growth and its pattern of development on the dentition is lacking, and Alterations in the bac terial flora, and changes in the chemical composition of plaque as it grows have been demonstrated.
Abstract: EPIDEMIOLOGICAL and experimental studies have dem onstrated that gingival inflammation, as well as dental caries, is dependent upon the presence of bacterial plaque on the teeth. 1 9 On a clean tooth surface, plaque begins to develop with the formation of a salivaryand glycoprotein containing pellicle 1 0 1 3 into which bacteria may subsequently colonize . 1 4 1 8 Alterations in the bac terial flora, and changes in the chemical composition of plaque as it grows have been demonstrated. 2 0 2 3 However, information on the rate of plaque growth and its pattern of development on the dentition is lacking.
345 citations
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TL;DR: The homogeneous conditions and conditions for inhibiting char formation by phenol were elucidated and it was found that mixtures of phenol and lignin become homogeneous at 400-600 degrees C and high water densities of 428-683 kg/m3, corresponding to maximum pressures of 93 MPa.
343 citations
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TL;DR: There is increasing evidence to indicate that multiple waves of antral follicles develop during the human menstrual cycle, comparable with those documented in several animal species; however, species-specific differences exist.
Abstract: BACKGROUND Ovarian follicles undergo dynamic morphologic and endocrinologic changes during the human menstrual cycle. The physiologic mechanisms underlying recruitment and selection of antral follicles in women are not fully elucidated. METHODS A comprehensive review of >200 studies was conducted using PubMed. The objective was to compare and contrast different perspectives on human antral folliculogenesis. RESULTS Antral folliculogenesis has been studied using histologic, endocrinologic and/or ultrasonographic techniques. Different theories of antral follicle recruitment include: (i) continuous recruitment throughout the menstrual cycle; (ii) recruitment of a 'cohort' of antral follicles once in the late-luteal phase or early-follicular phase of each cycle and (iii) recruitment of two or three 'cohorts' or 'waves' during each cycle. Generally, a single dominant follicle is selected in the mid-follicular phase of each cycle and this follicle ovulates at mid-cycle. However, a dominant follicle may also be selected during anovulatory waves that precede the ovulatory wave in some women. CONCLUSIONS There is increasing evidence to indicate that multiple waves of antral follicles develop during the human menstrual cycle. Ovarian follicular waves in women are comparable with those documented in several animal species; however, species-specific differences exist. Enhancing our understanding of the endocrine and paracrine mechanisms underlying antral follicular wave dynamics has clinical implications for understanding age-related changes in reproductive function, optimizing hormonal contraceptive and ovarian stimulation regimens and identifying non-invasive markers of the physiologic status of follicles which are predictive of oocyte competence and assisted reproduction outcomes.
343 citations
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TL;DR: Overall, it appears that treatment with E- 17s and progestogen in combination may be used to effectively control and synchronize follicular wave development and may have important implications in artificial control of ovarian cyclicity and superovulation.
343 citations
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TL;DR: The functional role of β-defensins is expanded, a protein family previously implicated in innate immunity, and an additional class of ligands for signaling through melanocortin receptors is identified, and its protein product binds with high affinity to the Mc1r.
Abstract: Genetic analysis of mammalian color variation has provided fundamental insight into human biology and disease. In most vertebrates, two key genes, Agouti and Melanocortin 1 receptor (Mc1r), encode a ligand-receptor system that controls pigment type-switching, but in domestic dogs, a third gene is implicated, the K locus, whose genetic characteristics predict a previously unrecognized component of the melanocortin pathway. We identify the K locus as beta-defensin 103 (CBD103) and show that its protein product binds with high affinity to the Mc1r and has a simple and strong effect on pigment type-switching in domestic dogs and transgenic mice. These results expand the functional role of beta-defensins, a protein family previously implicated in innate immunity, and identify an additional class of ligands for signaling through melanocortin receptors.
342 citations
Authors
Showing all 25277 results
Name | H-index | Papers | Citations |
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Tomas Hökfelt | 158 | 1033 | 95979 |
Frederick Wolfe | 119 | 417 | 101272 |
Christopher G. Goetz | 116 | 651 | 59510 |
John P. Giesy | 114 | 1162 | 62790 |
Helmut Kettenmann | 104 | 380 | 40211 |
Paul M. O'Byrne | 104 | 605 | 56520 |
Susan S. Taylor | 104 | 518 | 42108 |
Keith A. Hobson | 103 | 653 | 41300 |
Mark S. Tremblay | 100 | 541 | 43843 |
James F. Fries | 100 | 369 | 83589 |
Gordon McKay | 97 | 661 | 61390 |
Jonathan D. Adachi | 96 | 589 | 31641 |
Wenjun Zhang | 96 | 976 | 38530 |
William C. Dement | 96 | 340 | 43014 |
Chris Ryan | 95 | 971 | 34388 |