University of Science and Technology Beijing

About: University of Science and Technology Beijing is a education organization based out in Beijing, China. It is known for research contribution in the topics: Microstructure & Alloy. The organization has 41558 authors who have published 44473 publications receiving 623229 citations. The organization is also known as: Beijing Steel and Iron Institute.

Learning from a Mineral Structure toward an Ultra-Narrow-Band Blue-Emitting Silicate Phosphor RbNa3(Li3SiO4)4:Eu2+

Abstract: Learning from natural mineral structures is an efficient way to develop potential host lattices for applications in phosphor converted (pc)LEDs. A narrow-band blue-emitting silicate phosphor, RbNa3 (Li3 SiO4 )4 :Eu2+ (RNLSO:Eu2+ ), was derived from the UCr4 C4 -type mineral model. The broad excitation spectrum (320-440 nm) indicates this phosphor can be well matched with the near ultraviolet (n-UV) LED chip. Owing to the UCr4 C4 -type highly condensed and rigid framework, RNLSO:Eu2+ exhibits an extremely small Stokes shift and an unprecedented ultra-narrow (full-width at half-maximum, FWHM=22.4 nm) blue emission band (λem =471 nm) as well as excellent thermal stability (96 %@150 °C of the initial integrated intensity at 25 °C). The color gamut of the as-fabricated (pc)LEDs is 75 % NTSC for the application in liquid crystal displays from the prototype design of an n-UV LED chip and the narrow-band RNLSO:Eu2+ (blue), β-SiAlON:Eu2+ (green), and K2 SiF6 :Mn4+ (red) components as RGB emitters.

Enzyme-powered Janus platelet cell robots for active and targeted drug delivery

Abstract: Transforming natural cells into functional biocompatible robots capable of active movement is expected to enhance the functions of the cells and revolutionize the development of synthetic micromotors. However, present cell-based micromotor systems commonly require the propulsion capabilities of rigid motors, external fields, or harsh conditions, which may compromise biocompatibility and require complex actuation equipment. Here, we report on an endogenous enzyme-powered Janus platelet micromotor (JPL-motor) system prepared by immobilizing urease asymmetrically onto the surface of natural platelet cells. This Janus distribution of urease on platelet cells enables uneven decomposition of urea in biofluids to generate enhanced chemophoretic motion. The cell surface engineering with urease has negligible impact on the functional surface proteins of platelets, and hence, the resulting JPL-motors preserve the intrinsic biofunctionalities of platelets, including effective targeting of cancer cells and bacteria. The efficient propulsion of JPL-motors in the presence of the urea fuel greatly enhances their binding efficiency with these biological targets and improves their therapeutic efficacy when loaded with model anticancer or antibiotic drugs. Overall, asymmetric enzyme immobilization on the platelet surface leads to a biogenic microrobotic system capable of autonomous movement using biological fuel. The ability to impart self-propulsion onto biological cells, such as platelets, and to load these cellular robots with a variety of functional components holds considerable promise for developing multifunctional cell-based micromotors for a variety of biomedical applications.